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evolution
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the enzyme belongs to the astacin family of multidomain metallopeptidases, subgroups and domain structure, overall structure of mature astacin catalytic domains, overview
evolution
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the enzyme belongs to the astacin family of multidomain metallopeptidases, subgroups and domain structure, overall structure of mature astacin catalytic domains, overview
evolution
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the enzyme belongs to the astacin family of multidomain metallopeptidases, subgroups and domain structure, overall structure of mature astacin catalytic domains, overview
evolution
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the enzyme belongs to the astacin family of multidomain metallopeptidases, subgroups and domain structure, overall structure of mature astacin catalytic domains, overview
evolution
the enzyme belongs to the astacin family of multidomain metallopeptidases, subgroups and domain structure, overall structure of mature astacin catalytic domains, overview
evolution
the enzyme belongs to the family of extracellular zinc peptidases, termed stacin family, and of the metzincin superfamily
evolution
the enzyme is a member of the astacin family of metalloproteases
evolution
structural organization of the astacin-like gene family in planarians, overview. All members of the astacin family are characterized by two key elements: the 18-amino acid zinc-binding motif (HEXXHXXGFXHEXXRXDR), and the methionine-turn (Met-turn) sequence SXMHY
evolution
the enzyme belongs to the astacin family of zinc-dependent endopeptidase. All the members of this family have a protease domain containing approximately 200 amino acids, which shares an amino-acid sequence similarity of 29-99%. Astacin family members are characterized by a unique 18 amino acid signature sequence HEXXHXXGFXHEXXRXDR containing the Zn binding motif HEXXH present in all metalloendopeptidases. Most of the known family members contain a COOH terminal to the protease domain. They are found to contain one or more copies of the EGF (epidermal growth factor) like E and/or CUB (complement subcomponents) domain. Differences in the active sites and inhibitor sites of astacin/BMP1, human meprin alpha, and human meprin beta, overview. The subsites S1, S2, S3, S1', S2', S3' have differences in amino acid residues. Structure homology modelling
evolution
the enzyme encoded by ASTL belongs to the digestive and hatching enzymes cluster of the astacin enzyme family. Structure-activity relationship of astacin metalloproteases, EDTA is used to dock into the active site cleft of the astacins to know the interaction network and to identify the important residues for binding, comparative three-dimensional structure homology modeling (template crystal structure PDB ID 3LQB) and docking study, and potential binding site, detailed overview
evolution
the enzyme encoded by qcam1 belongs to the digestive and hatching enzymes cluster of the astacin enzyme family. Structure-activity relationship of astacin metalloproteases, EDTA is used to dock into the active site cleft of the astacins to know the interaction network and to identify the important residues for binding, comparative three-dimensional structure homology modeling (template crystal structure PDB ID 3LQB) and docking study, and potential binding site, detailed overview
malfunction
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heterologous expression of the Haemonchus contortus dpy-31 orthologue in a Caenorhabditis elegans dpy-31 mutant results in the full rescue of the mutant body form
malfunction
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heterologous expression of the Haemonchus contortus dpy-31 orthologue in a Caenorhabditis elegans dpy-31 mutant results in the full rescue of the mutant body form
malfunction
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nas-36 gene from Brugia malayi successfully complements the moult defects associated with Caenorhabditis elegans nas-36, nas-37 and nas-36/nas-37 double mutants
malfunction
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the nas-36 and nas-37 genes in Caenorhabditis elegans encode functionally conserved enzymes of the astacin metalloprotease family which, when mutated, result in a phenotype associated with the late-stage moulting defects, namely the inability to remove the preceding cuticle
malfunction
D5FM33
enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis
malfunction
enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis. Enzyme mutation causes temperature-sensitive lethality and cuticle defects, a DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant strain TP224 is able to rescue the Caenorhabditis elegans mutant
malfunction
enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis. The DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant is able to rescue the defective Caenorhabditis elegans DPY-31 enzyme mutant
malfunction
ablation of one of the two zinc metalloproteinases, meprin beta and BMP-1, leads to different collagen I associated phenotypes in vivo
malfunction
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enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis
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malfunction
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enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis. Enzyme mutation causes temperature-sensitive lethality and cuticle defects, a DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant strain TP224 is able to rescue the Caenorhabditis elegans mutant
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malfunction
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enzyme inhibition causes body morphology phenotypes consistent with the inhibition of proteases involved in cuticle collagen synthesis. The DPY-31 enzyme from the ovine gastrointestinal nematode Teladorsagia circumcincta mutant is able to rescue the defective Caenorhabditis elegans DPY-31 enzyme mutant
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metabolism
the enzyme Xhe2 expression depends entirely on transcription factor Pax3 function. Pax3 can induce premature hatching through the upregulation of several proteolytic enzymes including enzyme Xhe2
metabolism
the zinc metalloproteinases meprin beta and BMP-1 are differentially regulated by CaCl2, overview
physiological function
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effect of astacin on growth and color formation of juvenile red-white ornamental carp, overview. Carotenoid deposition in the skin, head, scale, and fin ray of fish fed diets containing astacin is significantly higher than that those fed the control. The fish are unable to fully synthesize carotenoid pigments and therefore need carotenoid to be added to their diets. Higher astacin content results in a brighter body color, astacin is mainly deposited in the skin, scales, and head
physiological function
the enzyme is a homologue of a vertebrate procollagen C-proteinase and performs a central role in cuticle formation of Caenorhabditis elegans
physiological function
the enzyme promotes Xenopus hatching. Xhe2 overexpression is sufficient to induce early hatching, indicating that Xhe2 is one of the key components of the degradation mechanism responsible for breaking down the vitelline membrane
physiological function
the protease is working at the hostparasite interface and is likely be exposed to the hosts immune response. Recombinant Ace-MTP-2 amplifies the in vitro release of TNFalpha and induces release of IFNgamma by lipopolysaccharide activated THP-1 macrophages, overview
physiological function
an increase in activity is reported under increasing calcium concentrations for BMP-1
physiological function
the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation
physiological function
the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation. Morphogenesis of the two-ring-shaped structure by visualization of Smed-ast-2 expression during regeneration. Smed-mmp1 and Smed-mmp2 are specialized in storage and secretion of extracellular matrix degrading enzymes
physiological function
the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation. Smed-mmp1 and Smed-mmp2 are specialized in storage and secretion of extracellular matrix degrading enzymes
physiological function
the astacin gene family of metalloproteinases in planarians, good candidate enzymes for generating dynamicity in the extracellular matrix. Astacins are secreted and membrane-bound metzincin metallopeptidases widespread among different animal phyla and involved in various physiological processes, including digestion, extracellular matrix (ECM) remodeling, morphogenesis, hatching, tissue remodeling, and differentiation. The ast-8 expression in the digestive system is a feature typically conserved in genes encoding astacins with a ShToxin domain
physiological function
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the enzyme is a homologue of a vertebrate procollagen C-proteinase and performs a central role in cuticle formation of Caenorhabditis elegans
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additional information
analysis of the astacin reaction mechanism from the crystal structure by computational methods, Optimized structure of the astacin active site with the model substrate bound, overview. All calculations were performed using density functional theory with the hybrid functional B3LYP, which is composed of Becke's three-parameter hybrid exchange functional (B3) and the correlation functional of Lee, Yang, and Parr. A model of the active site of astacin is built on the basis of the crystal structure of astacin in complex with the Pro-Leu-Gly-hydroxamate inhibitor, PDB entry 1QJJ
additional information
complementation of the Caenorhabditis elegans dpy-31 mutant with the Teladorsagia circumcincta dpy-31 gene
additional information
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complementation of the Caenorhabditis elegans dpy-31 mutant with the Teladorsagia circumcincta dpy-31 gene
additional information
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removal of the prosegment reveals a deep and extended active-site cleft, which in general shows preference for aspartate residues in the specificity pocket S1'
additional information
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removal of the prosegment reveals a deep and extended active-site cleft, which in general shows preference for aspartate residues in the specificity pocket, S1'
additional information
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removal of the prosegment reveals a deep and extended active-site cleft, which in general shows preference for aspartate residues in the specificity pocket, S1'
additional information
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removal of the prosegment reveals a deep and extended active-site cleft, which in general shows preference for aspartate residues in the specificity pocket, S1'
additional information
removal of the prosegment reveals a deep and extended active-site cleft, which in general shows preference for aspartate residues in the specificity pocket, S1'
additional information
the protease has a putative signal peptide, 11 potential phosphorylation sites, and two disulfide bridges revealed by computational analysis
additional information
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the protease has a putative signal peptide, 11 potential phosphorylation sites, and two disulfide bridges revealed by computational analysis
additional information
molecular modeling of LALP3 reveals that this isoform contains the zinc binding and Met-turn motifs, forming the active site, as has been observed in astacins. LALP3 epitopes are recognized by polyclonal antibodies raised against Loxosceles intermedia whole venom and LALP1 in a conformation-dependent manner
additional information
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molecular modeling of LALP3 reveals that this isoform contains the zinc binding and Met-turn motifs, forming the active site, as has been observed in astacins. LALP3 epitopes are recognized by polyclonal antibodies raised against Loxosceles intermedia whole venom and LALP1 in a conformation-dependent manner
additional information
structural differences between meprin beta (EC 3.4.24.63) and BMP-1. Molecular dynamics simulation
additional information
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structural differences between meprin beta (EC 3.4.24.63) and BMP-1. Molecular dynamics simulation
additional information
the hydrogen bonding residues of the enzyme are Ser155, His186, His192, Tyr238, and Asn217, comparative three-dimensional structure homology modeling and docking study, and potential binding site, detailed overview
additional information
the hydrogen bonding residues of the enzyme are Tyr60, His84, Glu85, His88, His94, and Asp119, comparative three-dimensional structure homology modeling and docking study, and potential binding site, detailed overview
additional information
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complementation of the Caenorhabditis elegans dpy-31 mutant with the Teladorsagia circumcincta dpy-31 gene
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