3.4.24.21: astacin
This is an abbreviated version!
For detailed information about astacin, go to the full flat file.
Reaction
Hydrolysis of peptide bonds in substrates containing five or additional information amino acids, preferentially with Ala in P1', and Pro in P2'
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Synonyms
Ace-MTP-2, Ancylostoma ceylanicum metalloprotease 2, Ast1, Ast2, Ast3, Ast4, Ast5, Ast6, Ast7, Ast9, astacin, astacin metallopeptidases, astacin metalloprotease, astacin-like metalloendopeptidase, astacin-like metalloprotease, astacin-like metalloprotease toxin 3, astacin-Like protease 3, Astacus protease, Astacus proteinase, ASTL, BMP-1, bone morphogenetic protein 1, carp nephrosin, crayfish small-molecule protease, Crayfish small-molecule proteinase, DPY-31, EC 3.4.99.6, LALP3, LAST, LAST_MAM, MEP1A, MEP1B, More, NAS-35, nas-36, nas-37, nephrosin, Ovastacin, Procollagen C-proteinase, Qcam1, Sc-AST, Smed-ast-1, Smed-ast-2, Smed-ast-3, Smed-ast-4, Smed-ast-5, Smed-ast-6, Smed-ast-7, Smed-ast-9, toxin 3, Xhe2
ECTree
Activating Compound
Activating Compound on EC 3.4.24.21 - astacin
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additional information
astacins undergo major rearrangement upon activation within an activation domain, and show a slight hinge movement when binding substrates or inhibitors. Activation of pro-astacin entails removal of the inhibiting pro-segment through successive cleavage events, which eventually replace the zinc-binding aspartate with the catalytic solvent molecule following an aspartate-switch mechanism and render the mature N-terminus at A1, enzyme activation mechanism, detailed overview
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additional information
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astacins undergo major rearrangement upon activation within an activation domain, and show a slight hinge movement when binding substrates or inhibitors. Activation of pro-astacin entails removal of the inhibiting pro-segment through successive cleavage events, which eventually replace the zinc-binding aspartate with the catalytic solvent molecule following an aspartate-switch mechanism and render the mature N-terminus at A1, enzyme activation mechanism, detailed overview
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additional information
-
astacins undergo major rearrangement upon activation within an activation domain, and show a slight hinge movement when binding substrates or inhibitors. Activation of pro-astacin entails removal of the inhibiting pro-segment through successive cleavage events, which eventually replace the zinc-binding aspartate with the catalytic solvent molecule following an aspartate-switch mechanism and render the mature N-terminus at A1, enzyme activation mechanism, detailed overview
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additional information
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isoform LAST, activity increases after incubation with trypsin
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additional information
-
astacins undergo major rearrangement upon activation within an activation domain, and show a slight hinge movement when binding substrates or inhibitors. Activation of pro-astacin entails removal of the inhibiting pro-segment through successive cleavage events, which eventually replace the zinc-binding aspartate with the catalytic solvent molecule following an aspartate-switch mechanism and render the mature N-terminus at A1, enzyme activation mechanism, detailed overview
-
additional information
-
astacins undergo major rearrangement upon activation within an activation domain, and show a slight hinge movement when binding substrates or inhibitors. Activation of pro-astacin entails removal of the inhibiting pro-segment through successive cleavage events, which eventually replace the zinc-binding aspartate with the catalytic solvent molecule following an aspartate-switch mechanism and render the mature N-terminus at A1, enzyme activation mechanism, detailed overview
-