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3.4.24.19: procollagen C-endopeptidase

This is an abbreviated version!
For detailed information about procollagen C-endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.19

Reaction

cleavage of the C-terminal propeptide at Ala-/-Asp in type I and II procollagens and at Arg-/-Asp in type III =

Synonyms

BMP-1, BMP1, bone morphogenetic protein 1, bone morphogenetic protein 1/tolloid, bone morphogenetic protein-1, bone morphogenic protein 1, Carboxy-terminal endopeptidase, carboxy-terminal procollagen peptidase, Carboxyl procollagen peptidase, carboxyl-procollagen peptidase, Carboxyprocollagen peptidase, dorsal-ventral patterning protein tolloid, mammalian tolloid, Mammalian tolloid protein, More, mTId, MtlD, PCP, PCP-1, PCP-2, Peptidase, procollagen C-terminal, procollagen C-peptidase, Procollagen C-proteinase, Procollagen C-terminal proteinase, Procollagen carboxy-terminal proteinase, Procollagen carboxypeptidase, Procollagen peptidase, Proteinase, procollagen C-terminal, suBMP-1, TId, Tld, tolloid, Type I procollagen C-proteinase, XBMP1-A, XBMP1-B

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.19 procollagen C-endopeptidase

Reference

topprint

Reference on EC 3.4.24.19 - procollagen C-endopeptidase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hojima, Y.; van der Rest, M.; Prockop, P.J.
Type I procollagen carboxyl-terminal proteinase from chick embryo tendons. Purification and characterization
J. Biol. Chem.
260
15996-16003
1985
Gallus gallus
Manually annotated by BRENDA team
Kessler, E.; Adar, R.
Type I procollagen C-proteinase from mouse fibroblasts. Purification and demonstration of a 55-kDa enhancer glycoprotein
Eur. J. Biochem.
186
115-121
1989
Mus musculus
Manually annotated by BRENDA team
Kadler, K.E.; Watson, R.B.
Procollagen C-peptidase: procollagen C-proteinase
Methods Enzymol.
248
771-781
1995
Gallus gallus, Mus musculus
Manually annotated by BRENDA team
Kessler, E.; Takahara, K.; Biniaminov, L.; Brusel, M.; Greenspan, D.S.
Bone morphogenic protein-1: the type I procollagen C-proteinase
Science
271
360-362
1971
Mus musculus
Manually annotated by BRENDA team
Leung, M.K.K.; Fessler, L.I.; Greenberg, D.B.; Fessler, J.H.
Separate amino and carboxyl procollagen peptidases in chick embryo tendon
J. Biol. Chem.
254
224-232
1979
Gallus gallus
Manually annotated by BRENDA team
Morris, N.P.; Fessler, L.I.; Fessler, J.H.
Procollagen propeptide release by procollagen peptidases and bacterial collagenase
J. Biol. Chem.
254
11024-11032
1979
Gallus gallus
Manually annotated by BRENDA team
Davidson, J.M.; Mc Eneany, L.S.G.; Bornstein, P.
Procollagen processing. Limited proteolysis of COOH-terminal extension peptides by a cathepsin-like protease secreted by tendon fibroblasts
Eur. J. Biochem.
100
551-558
1979
Gallus gallus
Manually annotated by BRENDA team
Njieha, F.K.; Morikawa, T.; Tuderman, L.; Prockop, D.J.
Partial purification of a procollagen C-proteinase. Inhibition by synthetic peptides and sequential cleavage of type I procollagen
Biochemistry
21
757-764
1982
Gallus gallus
Manually annotated by BRENDA team
Hojima, Y.; Behta, B.; Romanic, A.M.; Prockop, D.J.
Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase
Matrix Biol.
14
113-120
1994
Gallus gallus
Manually annotated by BRENDA team
Kessler, E.; Adar, R.; Goldberg, B.; Niece, R.
Partial purification and characterization of a procollagen C-proteinase from the culture medium of mouse fibroblasts
Coll. Relat. Res.
6
249-266
1986
Mus musculus
Manually annotated by BRENDA team
Adar, R.; Kessler, E.; Goldberg, B.
Evidence for a protein that enhances the activity of type I procollagen C-proteinase
Coll. Relat. Res.
6
267-277
1986
Mus musculus
Manually annotated by BRENDA team
Garrigue-Antar, L.; Barker, C.; Kadler, K.E.
Identification of amino acid residues in bone morphogenetic protein-1 important for procollagen C-proteinase activity
J. Biol. Chem.
276
26237-26242
2001
Homo sapiens (P13497)
Manually annotated by BRENDA team
Hartigan, N.; Garrigue-Antar, L.; Kadler, K.E.
Bone morphogenetic protein-1 (BMP-1). Identification of the minimal domain structure for procollagen C-proteinase activity
J. Biol. Chem.
278
18045-18049
2003
Homo sapiens (P13497)
Manually annotated by BRENDA team
Hintze, V.; Hoewel, M.; Wermter, C.; Grosse Berkhoff, E.; Becker-Pauly, C.; Beermann, B.; Yiallouros, I.; Stoecker, W.
The interaction of recombinant subdomains of the procollagen C-proteinase with procollagen I provides a quantitative explanation for functional differences between the two splice variants, mammalian tolloid and bone morphogenetic protein 1
Biochemistry
45
6741-6748
2006
Homo sapiens
Manually annotated by BRENDA team
Kessler, E.
Procollagen C-endopeptidase
Handbook of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
609-617
2004
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus, Strongylocentrotus purpuratus, Xenopus laevis
-
Manually annotated by BRENDA team
Moali, C.; Font, B.; Ruggiero, F.; Eichenberger, D.; Rousselle, P.; Francois, V.; Oldberg, A.; Bruckner-Tuderman, L.; Hulmes, D.J.
Substrate-specific modulation of a multisubstrate proteinase. C-terminal processing of fibrillar procollagens is the only BMP-1-dependent activity to be enhanced by PCPE-1
J. Biol. Chem.
280
24188-24194
2005
Homo sapiens
Manually annotated by BRENDA team
Wermter, C.; Hoewel, M.; Hintze, V.; Bombosch, B.; Aufenvenne, K.; Yiallouros, I.; Stoecker, W.
The protease domain of procollagen C-proteinase (BMP1) lacks substrate selectivity, which is conferred by non-proteolytic domains
Biol. Chem.
388
513-521
2007
Homo sapiens
Manually annotated by BRENDA team
Ge, G.; Zhang, Y.; Steiglitz, B.M.; Greenspan, D.S.
Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains
J. Biol. Chem.
281
10786-10798
2006
Homo sapiens
Manually annotated by BRENDA team
Fish, P.V.; Allan, G.A.; Bailey, S.; Blagg, J.; Butt, R.; Collis, M.G.; Greiling, D.; James, K.; Kendall, J.; McElroy, A.; McCleverty, D.; Reed, C.; Webster, R.; Whitlock, G.A.
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase
J. Med. Chem.
50
3442-3456
2007
Homo sapiens
Manually annotated by BRENDA team
Reid, R.R.; Mogford, J.E.; Butt, R.; deGiorgio-Miller, A.; Mustoe, T.A.
Inhibition of procollagen C-proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring
Wound Repair Regen.
14
138-141
2006
Oryctolagus cuniculus
Manually annotated by BRENDA team
Lesiak, M.; Augusciak-Duma, A.; Szydlo, A.; Pruszczynska, K.; Sieron, A.L.
Specific inhibition of procollagen C-endopeptidase activity by synthetic peptide with conservative sequence found in chordin
Acta Biochim. Pol.
55
297-305
2008
Homo sapiens (P13497)
Manually annotated by BRENDA team
Bailey, S.; Fish, P.V.; Billotte, S.; Bordner, J.; Greiling, D.; James, K.; McElroy, A.; Mills, J.E.; Reed, C.; Webster, R.
Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents
Bioorg. Med. Chem. Lett.
18
6562-6567
2008
Homo sapiens
Manually annotated by BRENDA team
Kobayashi, K.; Luo, M.; Zhang, Y.; Wilkes, D.C.; Ge, G.; Grieskamp, T.; Yamada, C.; Liu, T.C.; Huang, G.; Basson, C.T.; Kispert, A.; Greenspan, D.S.; Sato, T.N.
Secreted Frizzled-related protein 2 is a procollagen C proteinase enhancer with a role in fibrosis associated with myocardial infarction
Nat. Cell Biol.
11
46-55
2009
Mus musculus
Manually annotated by BRENDA team
Mesilaty-Gross, S.; Anikster, Y.; Vilensky, B.; Wolf, I.; Phillip, M.; Gat-Yablonski, G.
Different patterns of human serum procollagen C-proteinase enhancer1 (PCPE1)
Clin. Chim. Acta
403
76-80
2009
Homo sapiens
Manually annotated by BRENDA team
Kronenberg, D.; Vadon-Le Goff, S.; Bourhis, J.M.; Font, B.; Eichenberger, D.; Hulmes, D.J.; Moali, C.
Strong cooperativity and loose geometry between CUB domains are the basis for procollagen C-proteinase enhancer activity
J. Biol. Chem.
284
33437-33446
2009
Homo sapiens
Manually annotated by BRENDA team
Bekhouche, M.; Kronenberg, D.; Vadon-Le Goff, S.; Bijakowski, C.; Lim, N.H.; Font, B.; Kessler, E.; Colige, A.; Nagase, H.; Murphy, G.; Hulmes, D.J.; Moali, C.
Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity
J. Biol. Chem.
285
15950-15959
2010
Homo sapiens
Manually annotated by BRENDA team
Zhu, J.; Gardner, J.; Pullinger, C.R.; Kane, J.P.; Thompson, J.F.; Francone, O.L.
Regulation of apoAI processing by procollagen C-proteinase enhancer-2 and bone morphogenetic protein-1
J. Lipid Res.
50
1330-1339
2009
Homo sapiens
Manually annotated by BRENDA team
Lesiak, M.; Augusciak-Duma, A.; Szydlo, A.; Sieron, A.L.
Blocking angiogenesis with peptides that inhibit the activity of procollagen C-endopeptidase
Pharmacol. Rep.
61
468-476
2009
Homo sapiens
Manually annotated by BRENDA team
Canty-Laird, E.G.; Lu, Y.; Kadler, K.E.
Stepwise proteolytic activation of type I procollagen to collagen within the secretory pathway of tendon fibroblasts in situ
Biochem. J.
441
707-717
2012
Gallus gallus, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Canty-Laird, E.; Carre, G.A.; Mandon-Pepin, B.; Kadler, K.E.; Fabre, S.
First evidence of bone morphogenetic protein 1 expression and activity in sheep ovarian follicles
Biol. Reprod.
83
138-146
2010
Ovis aries
Manually annotated by BRENDA team
Vadon-Le Goff, S.; Kronenberg, D.; Bourhis, J.M.; Bijakowski, C.; Raynal, N.; Ruggiero, F.; Farndale, R.W.; Stoecker, W.; Hulmes, D.J.; Moali, C.
Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only
J. Biol. Chem.
286
38932-38938
2011
Homo sapiens
Manually annotated by BRENDA team
Turtle, E.; Chow, N.; Yang, C.; Sosa, S.; Bauer, U.; Brenner, M.; Solow-Cordero, D.; Ho, W.B.
Design and synthesis of procollagen C-proteinase inhibitors
Bioorg. Med. Chem. Lett.
22
7397-7401
2012
Homo sapiens
Manually annotated by BRENDA team
Chaudhuri, A.; Chakraborty, S.
Structure-activity relationship of astacin metalloproteases A comparative study using EDTA
Curr. Enzyme Inhib.
14
131-140
2018
Drosophila melanogaster (P25723), Mus musculus (P98063), Xenopus laevis (P98070)
-
Manually annotated by BRENDA team
Moschcovich, L.; Kessler, E.
Data comparing the kinetics of procollagen type I processing by bone morphogenetic protein 1 (BMP-1) with and without procollagen C-proteinase enhancer 1 (PCPE-1)
Data Brief
9
883-887
2016
Homo sapiens (P13497)
Manually annotated by BRENDA team
Pollard, R.D.; Blesso, C.N.; Zabalawi, M.; Fulp, B.; Gerelus, M.; Zhu, X.; Lyons, E.W.; Nuradin, N.; Francone, O.L.; Li, X.A.; Sahoo, D.; Thomas, M.J.; Sorci-Thomas, M.G.
Procollagen C-endopeptidase enhancer protein 2 (PCPE2) reduces atherosclerosis in mice by enhancing scavenger receptor class B1 (SR-BI)-mediated high-density lipoprotein (HDL)-cholesteryl ester uptake
J. Biol. Chem.
290
15496-15511
2015
Mus musculus (P98063)
Manually annotated by BRENDA team