3.4.24.19: procollagen C-endopeptidase

This is an abbreviated version!
For detailed information about procollagen C-endopeptidase, go to the full flat file.

Reaction

cleavage of the C-terminal propeptide at Ala-/-Asp in type I and II procollagens and at Arg-/-Asp in type III =

Synonyms

BMP-1, BMP1, bone morphogenetic protein 1, bone morphogenetic protein 1/tolloid, bone morphogenetic protein-1, bone morphogenic protein 1, Carboxy-terminal endopeptidase, carboxy-terminal procollagen peptidase, Carboxyl procollagen peptidase, carboxyl-procollagen peptidase, Carboxyprocollagen peptidase, dorsal-ventral patterning protein tolloid, mammalian tolloid, Mammalian tolloid protein, More, mTId, MtlD, PCP, PCP-1, PCP-2, Peptidase, procollagen C-terminal, procollagen C-peptidase, Procollagen C-proteinase, Procollagen C-terminal proteinase, Procollagen carboxy-terminal proteinase, Procollagen carboxypeptidase, Procollagen peptidase, Proteinase, procollagen C-terminal, suBMP-1, TId, Tld, tolloid, Type I procollagen C-proteinase, XBMP1-A, XBMP1-B

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.19 procollagen C-endopeptidase

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Results	in table
22	Activating Compound
16	AA Sequence
4	Application
1	CAS Registry Number
12	Cloned(Commentary)
175	Disease/ Diagnostics
17	General Information
2	General Stability
133	IC50 Value
236	Inhibitors
4	kcat/KM [mM/s]
6	KM Value [mM]
9	Localization
7	Metals/Ions
16	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
45	Organism
13	PDB ID
4	pH Optimum
1	pH Range
3	pH Stability
11	Protein Variants
10	Purification (Commentary)
1	Reaction
1	Reaction Type
45	Reference
56	Source Tissue
3	Specific Activity [micromol/min/mg]
2	Storage Stability
81	Substrates and Products (Substrate)
3	Subunits
117	Synonyms
1	Temperature Optimum [°C]
5	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.24.19 - procollagen C-endopeptidase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

C63G

Homo sapiens

P13497

site-directed mutagenesis

652144

C65A

Homo sapiens

P13497

site-directed mutagenesis

652144

C66G

Homo sapiens

P13497

site-directed mutagenesis

652144

C85A

Homo sapiens

P13497

site-directed mutagenesis

652144

E483K

Homo sapiens

P13497

site-directed mutagenesis

652388

E94A

Homo sapiens

P13497

site-directed mutagenesis

652144

K176A

Homo sapiens

P13497

site-directed mutagenesis

652144

K87A

Homo sapiens

P13497

site-directed mutagenesis

652144

K87A/K176A

Homo sapiens

P13497

site-directed mutagenesis

652144

additional information

2 entries

additional information

Homo sapiens

-

the most NH2-terminal CUB domain (CUB1) is not required for BMP1 secretion nor is the next CUB domain (CUB2) required for enzymatic activity. Secreted protease domain of BMP1, devoid of CUB or epidermal growth factor-like domains, have procollagen C-proteinase activity and activity for biosynthetic processing of biglycan, the latter with kinetics superior to those of the full-length proteins

687503

additional information

Mus musculus

-

homozygous null mice lacking PCBs encoded by BMP-1 are perinatally lethal and have reduced ossification of skull bones and defects in formation of the ventral body wall, procollagen processing and collagen fibrillogenesis

668838