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Frizzled-related protein
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secreted Frizzled-related protein sFRP2 serves as a direct enhancer of procollagen C proteinase activity of tolloid-like metalloproteinases. The level of fibrosis, in which procollagen processing by tolloid-like proteinases has a rate-limiting role, is markedly reduced in Sfrp2-null mice subjected to myocardial infarction. This reduced level of fibrosis is accompanied by significantly improved cardiac function
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heparin
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stimulation of BMP-1 activity by procollagen C-proteinase enhancer-1 is further increased by the presence of 0.05 mg/ml heparin
heparin sulfate
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in the presence of both procollagen C-proteinase enhancer-1 and heparin or heparan sulfate, the activity of BMP-1 is further stimulated
PCPE-1
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enhances degredation of procollagen type I 5 fold, enhances C-terminal processing of procollagen type III when this substrate is in its native, disulfide-bonded conformation, has no effect on the in vitro BMP-1 processing of procollagen VII, procollagen V N-propeptide, laminin 5 gamma2 chain, osteoglycin, prolysyl oxidase or chordin
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procollagen C-endopeptidase enhancer protein 1
PCPE1, a glycoprotein located in the extracellular matrix, enhances the cleavage of C-terminal procollagen by bone morphogenetic protein 1 (BMP1)
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procollagen C-endopeptidase enhancer protein 2
PCPE2, a 52-kDa glycoprotein located in the extracellular matrix, enhances the cleavage of C-terminal procollagen by bone morphogenetic protein 1 (BMP1). PCPE2 is not essential for in vivo pro-apoA-I processing. PCPE2 confers atheroprotection to apoA-I by enhancing BMP1-mediated catalytic cleavage, converting pro-apoA-I to mature apoA-I, and stimulating ABCA1-mediated cholesterol flux, but pro-apoA-I processing is not altered in the case of PCPE2 deficiency
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procollagen C-proteinase enhancer 1
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procollagen C-proteinase enhancer 2
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specifically activates bone morphogenetic protein-1, the CUB domains CUB1 and CUB2 of procollagen C-proteinase enhancer 1 are capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity
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procollagen C-proteinase enhancer-1
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procollagen C-proteinase enhancer-2
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procollagen C-proteinase enhancer-2 (PCPE2) interacts with BMP-1 and pro-apoAI to form a ternary pro-apoAI/BMP-1/PCPE2 complex, PCPE2 enhances the BMP-1 cleavage and maturation of pro-apoAI
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TGFbeta
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increases the expression of BMP-1 and Tld in human dermal fibroblasts
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additional information
both PCPE1 and PCPE2 are located in the extracellular matrix, where they facilitate bone morphogenetic protein 1 (BMP1) cleavage of C-terminal procollagen propeptides. PCPE2 and PCPE1 have different tissue distributions and heparin-binding affinities, suggesting a functional divergence. PCPE2 is heavily expressed in heart tissue in contrast to PCPE1. Both PCPE1 and PCPE2 have two CUB (Complement C1r/C1s, Uegf, Bmp1) domains separated by a short linker region, with each domain consisting of about 110 residues containing a beta-sandwich fold that mediates a variety of protein-protein interactions. Phenotype of PCPE2-/- mice, overview
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Enhancer glycoprotein
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stimulates activity
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Enhancer glycoprotein
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enhances activity of C-proteinase
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Enhancer glycoprotein
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characterization
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Enhancer glycoprotein
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enhancer may play a regulatory role in procollagen processing
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Enhancer glycoprotein
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bound to the carboxyl propeptide of type I procollagen
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procollagen C-proteinase enhancer 1
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enhances full length BMP1 and not truncated versions missing the most COOH-terminal EGF and CUB domains
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procollagen C-proteinase enhancer 1
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procollagen C-proteinase enhancer 1 specifically stimulates the PCP activity of bone morphogenic protein 1
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procollagen C-proteinase enhancer 1
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specifically activates bone morphogenetic protein-1, the CUB domains CUB1 and CUB2 of procollagen C-proteinase enhancer 1 are capable of enhancing BMP-1 activity and binding to a mini-procollagen substrate with nanomolar affinity
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procollagen C-proteinase enhancer 1
PCPE-1, CUB (Complement C1r/C1s, Uegf, BMP-1) and netrin-like (NTR) domains fragments of PCPE-1 are generated by limited proteolysis with trypsin and isolated by heparin affinity chromatography
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procollagen C-proteinase enhancer-1
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procollagen C-proteinase enhancer-1
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PCPE-1 is an extracellular glycoprotein that increases activity of BMP-1. PCPE-1 enhances proteolysis by binding solely to the procollagen C-propeptides
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