3.4.24.18: meprin A

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For detailed information about meprin A, go to the full flat file.

Reaction

Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues =

Synonyms

E-24.18, EC 3.4.24.11, Endopeptidase-2, M12.002, MEP1A, Meprin, meprin A, meprin A metalloprotease, meprin A metalloproteinase, meprin A subunit alpha, meprin alpha, meprin alpha1, meprin alpha2, meprin beta, meprin metalloprotease, meprin metalloproteinase, Meprin-a, meprin-alpha, metalloprotease meprin A, metalloproteinase meprin alpha, Mmepa, More, mouse meprin alpha, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA peptide hydrolase, PABA-peptide hydrolase, PPH, PPH alpha, PPH beta, procollagen proteinase, Rmepa

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.18 meprin A

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Results	in table
12	Activating Compound
15	AA Sequence
11	Application
1	CAS Registry Number
28	Cloned(Commentary)
642	Disease/ Diagnostics
2	Expression
63	General Information
1	General Stability
27	IC50 Value
144	Inhibitors
2	kcat/KM [mM/s]
20	Ki Value [mM]
56	KM Value [mM]
66	Localization
62	Metals/Ions
63	Molecular Weight [Da]
88	Natural Substrates/ Products (Substrates)
317	Organism
14	PDB ID
18	pH Optimum
3	pH Range
2	pH Stability
30	Posttranslational Modification
24	Protein Variants
25	Purification (Commentary)
1	Reaction
3	Reaction Type
90	Reference
125	Source Tissue
29	Specific Activity [micromol/min/mg]
3	Storage Stability
373	Substrates and Products (Substrate)
56	Subunits
65	Synonyms
23	Temperature Optimum [°C]
4	Temperature Stability [°C]
52	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.24.18 - meprin A

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

52

Mus musculus

-

quite stable, less than 10% activity lost in 30 min

650461

55

Mus musculus

-

wild-type enzyme retains 55% activity after 20 min, similar results for the mutants N41Q, N330Q, N426Q, N452Q, N546Q, and N553Q, mutants N234Q, N270Q, and N614Q retains 10% activity after 20 min, N152Q retains 6% activity after 5 min

652026

58

Mus musculus

-

t1/2: 50 min

31024

60

Mus musculus

-

t1/2: 30 min at pH 7.5

31019