3.4.24.18: meprin A
This is an abbreviated version!
For detailed information about meprin A, go to the full flat file.
Word Map on EC 3.4.24.18
-
3.4.24.18
-
3.4.24.11
-
enkephalinase
-
metalloendopeptidase
-
atrial
-
phosphoramidon
-
natriuretic
-
enkephalin
-
thiorphan
-
angiotensin-converting
-
angiotensin
-
astacins
-
metalloproteases
-
brush
-
bradykinin
-
3.4.15.1
-
captopril
-
neprilysin
-
metallopeptidases
-
anp
-
aminopeptidases
-
acetorphan
-
math
-
endopeptidases
-
brush-border
-
microvillar
-
actinonin
-
calla
-
bestatin
-
amastatin
-
azocasein
-
phosphoramidon-sensitive
-
sheddase
-
dipeptidylaminopeptidase
-
metzincins
-
pharmacology
-
neurokinins
-
astacin-like
-
met5enkephalin
-
depressor
-
medicine
-
tachykinins
-
neurotensin
-
leu-enkephalin
- 3.4.24.18
-
3.4.24.11
- enkephalinase
- metalloendopeptidase
- atrial
- phosphoramidon
-
natriuretic
- enkephalin
- thiorphan
-
angiotensin-converting
- angiotensin
- astacins
- metalloproteases
-
brush
- bradykinin
-
3.4.15.1
- captopril
- neprilysin
- metallopeptidases
- anp
- aminopeptidases
- acetorphan
-
math
- endopeptidases
-
brush-border
- microvillar
- actinonin
- calla
- bestatin
- amastatin
- azocasein
-
phosphoramidon-sensitive
- sheddase
-
dipeptidylaminopeptidase
-
metzincins
- pharmacology
- neurokinins
-
astacin-like
-
met5enkephalin
-
depressor
- medicine
- tachykinins
- neurotensin
- leu-enkephalin
Reaction
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues =
Synonyms
E-24.18, EC 3.4.24.11, Endopeptidase-2, M12.002, MEP1A, Meprin, meprin A, meprin A metalloprotease, meprin A metalloproteinase, meprin A subunit alpha, meprin alpha, meprin alpha1, meprin alpha2, meprin beta, meprin metalloprotease, meprin metalloproteinase, Meprin-a, meprin-alpha, metalloprotease meprin A, metalloproteinase meprin alpha, Mmepa, More, mouse meprin alpha, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA peptide hydrolase, PABA-peptide hydrolase, PPH, PPH alpha, PPH beta, procollagen proteinase, Rmepa
ECTree
3.4.24.18 meprin AAdvanced search results
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Reference on EC 3.4.24.18 - meprin A
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Beynon, R.J.; Shannon, J.D.; Bond, J.S.
Purification and characterization of a metallo-endoproteinase from mouse kidney
Biochem. J.
199
591-598
1981
Mus musculus
Butler, P.E.; McKay, M.J.; Bond, J.S.
Characterization of meprin, a membrane-bound metalloendopeptidase from mouse kidney
Biochem. J.
241
229-235
1987
Mus musculus
Stephenson, S.L.; Kenny, A.J.
The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme endopeptidase-2 and by rat microvillar membranes
Biochem. J.
255
45-51
1988
Rattus norvegicus
Sterchi, E.E.; Naim, H.Y.; Lentze, M.J.; Hauri, H.P.; Fransen, J.A.M.
N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: a metalloendopeptidase of the human intestinal microvillus membrane which degrades biologically active peptides
Arch. Biochem. Biophys.
265
105-118
1988
Homo sapiens, Homo sapiens PPH
Dumermuth, E.; Sterchi, E.E.; Jiang, W.; Wolz, R.L.; Bond, J.S.; Flannery, A.V.; Beynon, R.J.
The astacin family of metalloendopeptidases
J. Biol. Chem.
266
21381-21385
1991
Homo sapiens, Mus musculus, Homo sapiens PPH
Barnes, K.; Ingram, J.; Kenny, A.J.
Proteins of the kidney microvillar membrane. Structural and immunochemical properties of rat endopeptidase-2 and its immunohistochemical localization in tissues of rat and mouse
Biochem. J.
264
335-346
1989
Mus musculus, Rattus norvegicus
Kounnas, M.Z.; Woltz, R.L.; Gorbea, C.M.; Bond, J.S.
Meprin-A and -B. Cell surface endopeptidases of the mouse kidney
J. Biol. Chem.
266
17350-17357
1991
Mus musculus, Mus musculus male ICR
Johnson, G.D.; Hersh, L.B.
Cloning a rat meprin cDNA reveals the enzyme is a heterodimer [published erratum appears in J Biol Chem 1993 Aug 15;268(23):17647]
J. Biol. Chem.
267
13505-13512
1992
Rattus norvegicus
Marchand, P.; Tang, J.; Bond, J.S.
Membrane association and oligomeric organization of the alpha and beta subunits of mouse meprin A
J. Biol. Chem.
269
15388-15393
1994
Mus musculus, Rattus norvegicus
Yamaguchi, T.; Fukase, M.; Sugimoto, T.; Kido, H.; Chihara, K.
Purification of meprin from human kidney and its role in parathyroid hormone degradation
Biol. Chem. Hoppe-Seyler
375
821-824
1994
Homo sapiens, Homo sapiens PPH
Wolz, R.L.
A kinetic comparison of the homologous proteases astacin and meprin A
Arch. Biochem. Biophys.
310
144-151
1994
Mus musculus
Kaushal, G.P.; Walker, P.D.; Shah, S.V.
An old enzyme with a new function: purification and characterization of a distinct matrix-degrading metalloproteinase in rat kidney cortex and its identification as meprin
J. Cell Biol.
126
1319-1327
1994
Rattus norvegicus
Marchand, P.; Tang, J.; Johnson, G.D.; Bond, J.S.
COOH-Terminal proteolytic processing of secreted and membrane forms of the alpha subunit of the metalloprotease meprin A. Requirement of the I domain for processing in the endoplasmic reticulum
J. Biol. Chem.
270
5449-5456
1995
Mus musculus, Rattus norvegicus
Wolz, R.L.; Bond, J.S.
Meprins A and B
Methods Enzymol.
248
325-345
1995
Homo sapiens, Mus musculus, Rattus norvegicus, Homo sapiens PPH
Sterchi, E.E.; Naim, H.Y.; Lentze, M.J.
Biosynthesis of N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase: disulfide-linked dimers are formed at the site of synthesis in the rough endoplasmic reticulum
Arch. Biochem. Biophys.
265
119-127
1988
Homo sapiens, Homo sapiens PPH
Doll, B.A.; Villa, J.P.; Ishmael, F.T.; Bond, J.S.
Zinc ligands in an astacin family metalloprotease meprin A
Biol. Chem.
383
1167-1173
2002
Mus musculus
Bertenshaw, G.P.; Villa, J.P.; Hengst, J.A.; Bond, J.S.
Probing the active sites and mechanisms of rat metalloproteases meprin A and B
Biol. Chem.
383
1175-1183
2002
Rattus norvegicus
Kadowaki, T.; Tsukuba, T.; Bertenshaw, G.P.; Bond, J.S.
N-Linked oligosaccharides on the meprin A metalloprotease are important for secretion and enzymatic activity, but not for apical targeting
J. Biol. Chem.
275
25577-25584
2000
Mus musculus
Bertenshaw, G.P.; Turk, B.E.; Hubbard, S.J.; Matters, G.L.; Bylander, J.E.; Crisman, J.M.; Cantley, L.C.; Bond, J.S.
Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity
J. Biol. Chem.
276
13248-13255
2001
Mus musculus
Ishmael, F.T.; Norcum, M.T.; Benkovic, S.J.; Bond, J.S.
Multimeric structure of the secreted meprin A metalloproteinase and characterization of the functional protomer
J. Biol. Chem.
276
23207-23211
2001
Mus musculus
Bertenshaw, G.P.; Norcum, M.T.; Bond, J.S.
Structure of homo- and hetero-oligomeric meprin metalloproteases
J. Biol. Chem.
278
2522-2532
2003
Rattus norvegicus
Villa, J.P.; Bertenshaw, G.P.; Bond, J.S.
Critical Amino Acids in the Active Site of Meprin Metalloproteinases for Substrate and Peptide Bond Specificity
J. Biol. Chem.
278
42545-42550
2003
Mus musculus
Mathew, R.; Futterweit, S.; Valderrama, E.; Tarectecan, A.A.; Bylander, J.E.; Bond, J.S.; Trachtman, H.
Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis
Am. J. Physiol. Renal Physiol.
289
F911-F921
2005
Mus musculus, Rattus norvegicus
Kruse, M.; Becker, C.; Lottaz, D.; Koehler, D.; Yiallouros, I.; Krell, H.; Sterchi, E.E.; Stoecker, W.
Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors
Biochem. J.
378
383-389
2004
Homo sapiens
Hengst, J.A.; Bond, J.S.
Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization
J. Biol. Chem.
279
34856-34864
2004
Mus musculus
Ishmael, S.S.; Ishmael, F.T.; Jones, A.D.; Bond, J.S.
Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homooligomer
J. Biol. Chem.
281
37404-37415
2006
Mus musculus
DeGuzman, J.B.; Speiser, P.W.; Trachtman, H.
Urinary meprin-a: a potential marker of diabetic nephropathy
J. Pediatr. Endocrinol. Metab.
17
1663-1666
2004
Homo sapiens
Bylander, J.E.; Bertenshaw, G.P.; Matters, G.L.; Hubbard, S.J.; Bond, J.S.
Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities
Biol. Chem.
388
1163-1172
2007
Homo sapiens, Mus musculus
Heinzelmann-Schwarz, V.A.; Scolyer, R.A.; Scurry, J.P.; Smith, A.N.; Gardiner-Garden, M.; Biankin, A.V.; Baron-Hay, S.; Scott, C.; Ward, R.L.; Fink, D.; Hacker, N.F.; Sutherland, R.L.; OBrien, P.M.
Low meprin alpha expression differentiates primary ovarian mucinous carcinoma from gastrointestinal cancers that commonly metastasise to the ovaries
J. Clin. Pathol.
60
622-626
2007
Homo sapiens
Becker-Pauly, C.; Hoewel, M.; Walker, T.; Vlad, A.; Aufenvenne, K.; Oji, V.; Lottaz, D.; Sterchi, E.E.; Debela, M.; Magdolen, V.; Traupe, H.; Stoecker, W.
The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation
J. Invest. Dermatol.
127
1115-1125
2007
Homo sapiens
Herzog, C.; Haun, R.S.; Kaushal, V.; Mayeux, P.R.; Shah, S.V.; Kaushal, G.P.
Meprin A and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta
Biochem. Biophys. Res. Commun.
379
904-908
2009
Mus musculus, Rattus norvegicus (Q64230)
Takayama, J.; Takaoka, M.; Yamamoto, S.; Nohara, A.; Ohkita, M.; Matsumura, Y.
Actinonin, a meprin inhibitor, protects ischemic acute kidney injury in male but not in female rats
Eur. J. Pharmacol.
581
157-163
2008
Rattus norvegicus
Ambort, D.; Stalder, D.; Lottaz, D.; Huguenin, M.; Oneda, B.; Heller, M.; Sterchi, E.E.
A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin
FEBS J.
275
4490-4509
2008
Canis lupus familiaris
Banerjee, S.; Oneda, B.; Yap, L.M.; Jewell, D.P.; Matters, G.L.; Fitzpatrick, L.R.; Seibold, F.; Sterchi, E.E.; Ahmad, T.; Lottaz, D.; Bond, J.S.
MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease
Mucosal Immunol.
2
220-231
2009
Mus musculus (P28825), Mus musculus, Homo sapiens (Q16819), Homo sapiens
Ohler, A.; Debela, M.; Wagner, S.; Magdolen, V.; Becker-Pauly, C.
Analyzing the protease web in skin: meprin metalloproteases are activated specifically by KLK4, 5 and 8 vice versa leading to processing of proKLK7 thereby triggering its activation
Biol. Chem.
391
455-460
2010
Homo sapiens
Boerrigter, G.; Costello-Boerrigter, L.C.; Harty, G.J.; Huntley, B.K.; Cataliotti, A.; Lapp, H.; Burnett, J.C.
B-type natriuretic peptide 8-32, which is produced from mature BNP 1-32 by the metalloprotease meprin A, has reduced bioactivity
Am. J. Physiol. Regul. Integr. Comp. Physiol.
296
R1744-R1750
2009
Homo sapiens
Gao, P.; Guo, R.W.; Chen, J.F.; Chen, Y.; Wang, H.; Yu, Y.; Huang, L.
A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice
Atherosclerosis
207
84-92
2009
Mus musculus
Schuette, A.; Hedrich, J.; Stoecker, W.; Becker-Pauly, C.
Let it flow: Morpholino knockdown in zebrafish embryos reveals a pro-angiogenic effect of the metalloprotease meprin alpha2
PLoS ONE
5
e8835
2010
Danio rerio (B3DKP9), Danio rerio (Q5RHM1), Danio rerio, Homo sapiens (Q16819), Homo sapiens
Gao, P.; Si, L.Y.
Meprin-alpha metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-alpha and interleukin-1beta in peripheral blood mononuclear cells via activation of NF-kappaB
Regul. Pept.
160
99-105
2010
Mus musculus
Dickey, D.M.; Potter, L.R.
Human B-type natriuretic peptide is not degraded by meprin A
Biochem. Pharmacol.
80
1007-1011
2010
Homo sapiens
García-Caballero, A.; Ishmael, S.; Dang, Y.; Gillie, D.; Bond, J.; Milgram, S.; Stutts, M.
Activation of the epithelial sodium channel by the metalloprotease meprin beta subunit
Channels
5
14-22
2011
Homo sapiens
Kaushal, G.P.; Haun, R.S.; Herzog, C.; Shah, S.V.
Meprin A metalloproteinase and its role in acute kidney injury
Am. J. Physiol. Renal Physiol.
304
F1150-F1158
2013
Homo sapiens, Mus musculus, Rattus norvegicus, Mus musculus C57BL/6N
Bao, J.; Yura, R.E.; Matters, G.L.; Bradley, S.G.; Shi, P.; Tian, F.; Bond, J.S.
Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin
Am. J. Physiol. Renal Physiol.
305
F714-F726
2013
Canis lupus familiaris, Canis lupus familiaris Madin-Darby, Mus musculus, Mus musculus C57BL/6
Niyitegeka, J.M.; Bastidas, A.C.; Newman, R.H.; Taylor, S.S.; Ongeri, E.M.
Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury
Am. J. Physiol. Renal Physiol.
308
F56-68
2015
Mus musculus
Broder, C.; Becker-Pauly, C.
The metalloproteases meprin alpha and meprin beta: Unique enzymes in inflammation, neurodegeneration, cancer and fibrosis
Biochem. J.
450
253-264
2013
Danio rerio, Homo sapiens, Mus musculus
Madoux, F.; Tredup, C.; Spicer, T.P.; Scampavia, L.; Chase, P.S.; Hodder, P.S.; Fields, G.B.; Becker-Pauly, C.; Minond, D.
Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin alpha and beta
Biopolymers
102
396-406
2014
Homo sapiens
Hirano, M.; Ma, B.; Kawasaki, N.; Oka, S.; Kawasaki, T.
Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney
Glycobiology
22
84-95
2012
Mus musculus, Mus musculus BALB/c
Herzog, C.; Haun, R.S.; Ludwig, A.; Shah, S.V.; Kaushal, G.P.
ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A
J. Biol. Chem.
289
13308-13322
2014
Homo sapiens, Homo sapiens (Q16819), Homo sapiens (Q16820)
Keiffer, T.R.; Bond, J.S.
Meprin metalloproteases inactivate interleukin 6
J. Biol. Chem.
289
7580-7588
2014
Homo sapiens, Mus musculus, Mus musculus C57BL6
Chaudhuri, A.; Sarkar, I.; Chakraborty, S.
Comparative analysis of binding sites of human meprins with hydroxamic acid derivative by molecular dynamics simulation study
J. Biomol. Struct. Dyn.
32
1969-1978
2014
Homo sapiens
Prox, J.; Arnold, P.; Becker-Pauly, C.
Meprin alpha and meprin beta: procollagen proteinases in health and disease
Matrix Biol.
44-46
7-13
2015
Homo sapiens, Mus musculus
Broder, C.; Arnold, P.; Vadon-Le Goff, S.; Konerding, M.A.; Bahr, K.; Mueller, S.; Overall, C.M.; Bond, J.S.; Koudelka, T.; Tholey, A.; Hulmes, D.J.; Moali, C.; Becker-Pauly, C.
Metalloproteases meprin ? and meprin ? are C- and N-procollagen proteinases important for collagen assembly and tensile strength
Proc. Natl. Acad. Sci. USA
110
14219-14224
2013
Mus musculus
Schulze, A.; Wermann, M.; Demuth, H.U.; Yoshimoto, T.; Ramsbeck, D.; Schlenzig, D.; Schilling, S.
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis
Anal. Biochem.
559
11-16
2018
Homo sapiens (Q16819)
Chaudhuri, A.; Bera, A.K.; Sarkar, I.; Chakraborty, S.
Insights from analysis of binding sites of human meprins screening of inhibitors by molecular dynamics simulation study
Comb. Chem. High Throughput Screen.
19
246-258
2016
Homo sapiens (Q16819), Homo sapiens
Chaudhuri, A.; Chakraborty, S.
Structure-activity relationship of astacin metalloproteases A comparative study using EDTA
Curr. Enzyme Inhib.
14
131-140
2018
Mus musculus (P28825), Rattus norvegicus (Q64230)
-
Sato, Y.; Kobayashi, D.; Kohno, T.; Kidani, Y.; Prox, J.; Becker-Pauly, C.; Hattori, M.
Determination of cleavage site of Reelin between its sixth and seventh repeat and contribution of meprin metalloproteases to the cleavage
J. Biochem.
159
305-312
2015
Mus musculus (P28825)
Becker-Pauly, C.; Rose-John, S.
Meprin and ADAM metalloproteases two sides of the same coin?
Matrix Metalloproteinase Biology (ed. Sagi I. and Gaffney J.P.)
7j
115-130
2015
Homo sapiens (Q16819)
-
Breig, O.; Yates, M.; Neaud, V.; Couchy, G.; Grigoletto, A.; Lucchesi, C.; Prox, J.; Zucman-Rossi, J.; Becker-Pauly, C.; Rosenbaum, J.
Metalloproteinase meprin alpha regulates migration and invasion of human hepatocarcinoma cells and is a mediator of the oncoprotein Reptin
Oncotarget
8
7839-7851
2017
Homo sapiens (Q16819), Homo sapiens
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