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3.4.24.18: meprin A

This is an abbreviated version!
For detailed information about meprin A, go to the full flat file.

Word Map on EC 3.4.24.18

Reaction

Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues =

Synonyms

E-24.18, EC 3.4.24.11, Endopeptidase-2, M12.002, MEP1A, Meprin, meprin A, meprin A metalloprotease, meprin A metalloproteinase, meprin A subunit alpha, meprin alpha, meprin alpha1, meprin alpha2, meprin beta, meprin metalloprotease, meprin metalloproteinase, Meprin-a, meprin-alpha, metalloprotease meprin A, metalloproteinase meprin alpha, Mmepa, More, mouse meprin alpha, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA peptide hydrolase, PABA-peptide hydrolase, PPH, PPH alpha, PPH beta, procollagen proteinase, Rmepa

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.18 meprin A

Natural Substrates Products

Natural Substrates Products on EC 3.4.24.18 - meprin A

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
alpha-melanocyte-stimulating hormone + H2O
?
show the reaction diagram
-
-
-
-
?
angiotensin I + H2O
?
show the reaction diagram
angiotensin II + H2O
?
show the reaction diagram
B-type natriuretic peptide + H2O
?
show the reaction diagram
-
-
-
-
?
bombesin + H2O
?
show the reaction diagram
-
-
-
-
?
bradykinin + H2O
?
show the reaction diagram
catalytic subunit of protein kinase A + H2O
?
show the reaction diagram
-
in rat kidney
-
-
?
CCK8NH2 + H2O
L-Asp-L-Tyr-L-Met-Gly-L-Trp-L-Met + L-Asp-L-Phe
show the reaction diagram
-
-
-
-
?
cerulein + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen IV + H2O
?
show the reaction diagram
collagen type IV + H2O
?
show the reaction diagram
-
meprin alpha can degrade collagen type IV
-
-
?
E-cadherin + H2O
?
show the reaction diagram
fibrillar procollagen type I + H2O
fibrillar collagen type I + fibrillar collagen type I propeptide
show the reaction diagram
fibrillar procollagen type III + H2O
fibrillar collagen type III + fibrillar collagen type I propeptide
show the reaction diagram
Fibronectin + H2O
?
show the reaction diagram
gastrin + H2O
?
show the reaction diagram
-
-
-
?
gastrin-releasing peptide-(14-27) + H2O
?
show the reaction diagram
-
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
-
in rat kidney
-
-
?
Glucagon + H2O
?
show the reaction diagram
-
-
-
-
?
insulin + H2O
?
show the reaction diagram
-
in mouse kidney
-
-
?
insulin B chain + H2O
?
show the reaction diagram
-
in human small intestine
-
-
?
interleukin-1beta + H2O
?
show the reaction diagram
-
meprin beta activates interleukin 18
-
-
?
Laminin + H2O
?
show the reaction diagram
-
in rat kidney
-
-
?
laminin V + H2O
?
show the reaction diagram
-
-
-
?
luteinizing-hormone-releasing hormone + H2O
?
show the reaction diagram
MMP1 protein + H2O
?
show the reaction diagram
Muc2 protein + H2O
?
show the reaction diagram
neuropeptide Y + H2O
?
show the reaction diagram
-
-
-
-
?
neurotensin + H2O
?
show the reaction diagram
Nidogen + H2O
?
show the reaction diagram
-
in rat kidney
-
-
?
nidogen 1 + H2O
?
show the reaction diagram
occludin + H2O
?
show the reaction diagram
oxytocin + H2O
?
show the reaction diagram
-
in human small intestine
-
-
?
Parathyroid hormone + H2O
?
show the reaction diagram
parathyroid hormone fragment 13-34 + H2O
?
show the reaction diagram
-
-
-
-
?
Pro-interleukin-1beta + H2O
?
show the reaction diagram
-
-
-
-
?
procollagen I + H2O
collagen I + propeptide of collagen III
show the reaction diagram
-
meprin alpha removes both the C- and N-propeptides of type I procollagen, subsequently releasing fibril-forming mature collagen molecules. The C-terminal cleavage sites in the proalpha1(I) chain generated by the enzyme is identified as Ala1218/Asp1219, identical to the BMP-1 cleavage site, and also Arg1227/Asp1228, nine residues C-terminal to the BMP-1 cleavage site
-
-
?
procollagen III + H2O
?
show the reaction diagram
-
meprin alpha can process procollagen III
-
-
?
protein kinase A + H2O
?
show the reaction diagram
-
the enzyme cleaves at defined sites, isoform-specific interactions between the catalytic subunit of PKA (PKA C) and meprins, overview
-
-
?
Reelin + H2O
?
show the reaction diagram
Reelin is a secreted glycoprotein whose function is regulated by proteolysis
-
-
?
Secretin + H2O
?
show the reaction diagram
-
-
-
-
?
Substance P + H2O
?
show the reaction diagram
tenascin-C + H2O
?
show the reaction diagram
tissue growth factor-alpha + H2O
?
show the reaction diagram
-
meprin alpha can process tissue growth factor-alpha
-
-
?
tumor necrosis factor alpha + H2O
?
show the reaction diagram
-
in rat kidney
-
-
?
valosin + H2O
?
show the reaction diagram
-
-
-
-
?
vascular endothelial growth factor A + H2O
?
show the reaction diagram
-
-
-
-
?
Vasoactive intestinal peptide + H2O
?
show the reaction diagram
-
-
-
-
?
additional information
?
-