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3.4.24.18: meprin A

This is an abbreviated version!
For detailed information about meprin A, go to the full flat file.

Word Map on EC 3.4.24.18

Reaction

Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues =

Synonyms

E-24.18, EC 3.4.24.11, Endopeptidase-2, M12.002, MEP1A, Meprin, meprin A, meprin A metalloprotease, meprin A metalloproteinase, meprin A subunit alpha, meprin alpha, meprin alpha1, meprin alpha2, meprin beta, meprin metalloprotease, meprin metalloproteinase, Meprin-a, meprin-alpha, metalloprotease meprin A, metalloproteinase meprin alpha, Mmepa, More, mouse meprin alpha, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA peptide hydrolase, PABA-peptide hydrolase, PPH, PPH alpha, PPH beta, procollagen proteinase, Rmepa

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.18 meprin A

KI Value

KI Value on EC 3.4.24.18 - meprin A

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00002
actinonin
0.0044
batimastat
0.074 - 0.74
captopril
0.00053
DL-Pro-DL-Leu-Gly-NH2
-
pH and temperature not specified in the publication
0.00014 - 0.00017
galardin
0.00053
L-Pro-L-Leu-Gly-hydroxamate
-
pH 7.5, 37°C
0.0004
N-isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid
-
pH 7.5, 37°C
0.0022
N-[1-[(1-amino-1-oxopropan-2-yl)amino]-3-(naphthalen-1-yl)-1-oxopropan-2-yl]-4-(hydroxyamino)-2-(2-methylpropyl)pent-4-enamide
-
pH and temperature not specified in the publication
0.0015
N-[4-(hydroxyamino)-2-(2-methylpropyl)pent-4-enoyl]-3-methylvalyl-N-(2-aminoethyl)-DL-alaninamide
-
pH and temperature not specified in the publication
0.0004
N4-hydroxy-N1-[3-(1H-indol-3-yl)-1-(methylamino)-1-oxopropan-2-yl]-2-(2-methylpropyl)butanediamide
-
pH and temperature not specified in the publication
0.00053
Pro-Leu-Gly-hydroxamate
pH and temperature not specified in the publication
0.0016
Ro 32-7315
-
pH 7.5, 37°C
0.0022
TAPI-0
-
pH 7.5, 37°C
0.0015
TAPI-2
-
pH 7.5, 37°C