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3.4.24.18: meprin A

This is an abbreviated version!
For detailed information about meprin A, go to the full flat file.

Word Map on EC 3.4.24.18

Reaction

Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues =

Synonyms

E-24.18, EC 3.4.24.11, Endopeptidase-2, M12.002, MEP1A, Meprin, meprin A, meprin A metalloprotease, meprin A metalloproteinase, meprin A subunit alpha, meprin alpha, meprin alpha1, meprin alpha2, meprin beta, meprin metalloprotease, meprin metalloproteinase, Meprin-a, meprin-alpha, metalloprotease meprin A, metalloproteinase meprin alpha, Mmepa, More, mouse meprin alpha, N-Benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase, PABA peptide hydrolase, PABA-peptide hydrolase, PPH, PPH alpha, PPH beta, procollagen proteinase, Rmepa

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.18 meprin A

Cloned

Cloned on EC 3.4.24.18 - meprin A

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed as a recombinant protein
-
expressed in human embryonic kidney 293 cells
-
expressed in human embryonic kidney 293 cells ATCC 1573 CRL
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gene MEP1A, gene MEP1A is genetically associated with inflammatory bowel disease, on the basis of single nucleotide polymorphisms in ulcerative colitis patients
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gene MEP1A, quantitative RT-PCR enzyme expression analysis
gene MEP1A, recombinant enzyme expression in COS-7 and HEK293T cells
gene MEP1A, recombinant expression of N-terminally Strep-tagged meprin alpha in Drosophila melanogaster S2 cells, which are stably transfected with pMT/BiP/V5-C-hMep alpha22-600
gene Mep1A, sequence comparisons
gene MEP1B, recombinant expression of meprin alpha in Pichia pastoris strain X-33
homooligomeric meprin A produced by transfecting cells with alpha or beta cDNA
-
human embryonic kidney 293 cells stably transfected with cDNA
-
human PPH
meprin alpha subunit
mouse
pcDNAI/Amp plasmid containing full-length wild-type meprin alpha-subunit cDNA transfected into MDCK cells and human embryonic kidney 293 cells
-
recombinant expression of C-terminally His6-tagged meprin alpha protein (1-615) in human HEK-293 cells
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recombinant expression of homomeric enzyme in HEK-293 cells
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recombinant expression of Strep-tagged enzyme in Spodoptera frugiperda Sf9 insect cells
-
stable expression of HA-tagged alpha-and beta-subunits in HEK-293 cells and secretion to the culture medium
stable expression of HA-tagged alpha-subunit in HEK-293 cells and secretion to the culture medium
stable expression of HA-tagged beta-subunit in HEK-293 cells and secretion to the culture medium