3.4.24.17: stromelysin 1

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For detailed information about stromelysin 1, go to the full flat file.

Word Map on EC 3.4.24.17

3.4.24.17

metalloproteinases

mmp-1

cartilage

arthritis

joint

osteoarthritis

rheumatoid

synovial

chondrocytes

necrosis

timps

articular

gelatinase

tnf

interleukin-1

knee

zymography

degeneration

aggrecan

proteoglycans

c-reactive

interstitial

gelatin

plasminogen

proteinases

cox-2

synoviocytes

il-1beta

fibroblast-like

cruciate

intervertebral

ligament

matrilysin

pulposus

matrix-degrading

adamts-4

synovitis

thrombospondin

intra-articular

subchondral

emmprin

chondroprotective

photoaging

collagenases

diagnostics

medicine

aggrecanase

prommp-9

neoepitope

gelatinolytic

mt1-mmp

collagenolytic

drug development

analysis

Reaction

preferential cleavage where P1', P2' and P3' are hydrophobic residues =

Synonyms

Collagen-activating protein, Collagenase activating protein, matrix metalloprotease-3, Matrix metalloproteinase 3, matrix metalloproteinase-3, matrixin, MMP-3, MMP3, Neutral proteoglycanase, Procollagenase activator, Proteoglycanase, PTR1 protein, ST1, Stromelysin, stromelysin-1, Transin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.17 stromelysin 1

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Results	in table
8	Activating Compound
15	AA Sequence
22	Application
1	CAS Registry Number
11	Cloned(Commentary)
5	Crystallization (Commentary)
7657	Disease/ Diagnostics
22	Expression
30	General Information
4	General Stability
42	IC50 Value
273	Inhibitors
6	kcat/KM [mM/s]
76	Ki Value [mM]
11	KM Value [mM]
25	Localization
35	Metals/Ions
12	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
105	Organism
70	PDB ID
15	pH Optimum
3	pH Range
11	pH Stability
2	Posttranslational Modification
14	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
88	Source Tissue
12	Specific Activity [micromol/min/mg]
5	Storage Stability
142	Substrates and Products (Substrate)
7	Subunits
109	Synonyms
12	Temperature Optimum [°C]
5	Temperature Stability [°C]
10	Turnover Number [1/s]

pH Optimum

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pH Optimum on EC 3.4.24.17 - stromelysin 1

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5.3 - 5.5

Homo sapiens

digestion of aggrecan core protein

31017

5.5

Homo sapiens

optimum for proteoglycan monomer, digestion of fibronectin and gelatin is more extensive at pH 5.5 than at pH 7.5

31009

5 entries

6 - 8.6

Oryctolagus cuniculus

glomerular basement membrane

6.2

azocoll

assay at

7.2

assay at

7.4

assay at

7.5

assay at

7.5 - 7.8

7.6

assay at