3.4.24.17: stromelysin 1
This is an abbreviated version!
For detailed information about stromelysin 1, go to the full flat file.
Word Map on EC 3.4.24.17
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3.4.24.17
-
metalloproteinases
-
mmp-1
-
cartilage
-
arthritis
-
joint
-
osteoarthritis
-
rheumatoid
-
synovial
-
chondrocytes
-
necrosis
-
timps
-
articular
-
gelatinase
-
tnf
-
interleukin-1
-
knee
-
zymography
-
degeneration
-
aggrecan
-
proteoglycans
-
c-reactive
-
interstitial
-
gelatin
-
plasminogen
-
proteinases
-
cox-2
-
synoviocytes
-
il-1beta
-
fibroblast-like
-
cruciate
-
intervertebral
-
ligament
-
matrilysin
-
pulposus
-
matrix-degrading
-
adamts-4
-
synovitis
-
thrombospondin
-
intra-articular
-
subchondral
-
emmprin
-
chondroprotective
-
photoaging
-
collagenases
-
diagnostics
-
medicine
-
aggrecanase
-
prommp-9
-
neoepitope
-
gelatinolytic
-
mt1-mmp
-
collagenolytic
-
drug development
-
analysis
- 3.4.24.17
- metalloproteinases
- mmp-1
- cartilage
- arthritis
- joint
- osteoarthritis
-
rheumatoid
- synovial
- chondrocytes
- necrosis
- timps
-
articular
- gelatinase
- tnf
- interleukin-1
- knee
-
zymography
- degeneration
- aggrecan
- proteoglycans
-
c-reactive
-
interstitial
- gelatin
- plasminogen
- proteinases
- cox-2
- synoviocytes
- il-1beta
-
fibroblast-like
-
cruciate
-
intervertebral
- ligament
- matrilysin
- pulposus
-
matrix-degrading
- adamts-4
- synovitis
- thrombospondin
-
intra-articular
-
subchondral
-
emmprin
-
chondroprotective
-
photoaging
- collagenases
- diagnostics
- medicine
- aggrecanase
-
prommp-9
-
neoepitope
-
gelatinolytic
- mt1-mmp
-
collagenolytic
- drug development
- analysis
Reaction
preferential cleavage where P1', P2' and P3' are hydrophobic residues =
Synonyms
Collagen-activating protein, Collagenase activating protein, matrix metalloprotease-3, Matrix metalloproteinase 3, matrix metalloproteinase-3, matrixin, MMP-3, MMP3, Neutral proteoglycanase, Procollagenase activator, Proteoglycanase, PTR1 protein, ST1, Stromelysin, stromelysin-1, Transin
ECTree
3.4.24.17 stromelysin 1Advanced search results
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Reference on EC 3.4.24.17 - stromelysin 1
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okada, Y.; Nagase, H.; Harris, E.D.
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization
J. Biol. Chem.
261
14245-14255
1986
Homo sapiens
Chin, J.R.; Murphy, G.; Werb, Z.
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates
J. Biol. Chem.
260
12367-12376
1985
Oryctolagus cuniculus
Galloway, W.A.; Murphy, G.; Sandy, J.D.; Gavrilovic, J.; Cawston, T.E.; Reanolds, J.J.
Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components
Biochem. J.
209
741-752
1983
Oryctolagus cuniculus
Hanglow, A.C.; Lugo, A.; Walsky, R.; Visnick, M.; Coffey, J.W.; Fotouhi, N.
Inhibition of human stromelysin by peptides based on the N-terminal domain of tissue inhibitor of metalloproteinases-1
Biochem. Biophys. Res. Commun.
205
1156-1163
1994
Homo sapiens
Izquierdo-Martin, M.; Chapman, K.T.; Hagmann, W.K.; Stein, R.L.
Studies on the kinetic and chemical mechanism of inhibition of stromelysin by an N-(carboxyalkyl)dipeptide
Biochemistry
33
1356-1365
1994
Homo sapiens
Mast, A.E.; Enghild, J.J.; Nagase, H.; Suzuki, K.; Pizzo, S.V.; Salvesen, G.
Kinetics and physiologic relevance of the inactivation of alpha 1-proteinase inhibitor, alpha 1-antichymotrypsin, and antithrombin III by matrix metalloproteinases-1 (tissue collagenase), -2 (72-kDa gelatinase/type IV collagenase), and -3 (stromelysin)
J. Biol. Chem.
266
15810-15816
1991
Homo sapiens
Odake, S.; Morita, Y.; Morikawa, T.; Yoshida, N.; Hori, H.; Nagai, Y.
Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids
Biochem. Biophys. Res. Commun.
199
1442-1446
1994
Homo sapiens
Marcy, A.I.; Eiberger, L.L.; Harrison, R.; Chan, K.; Hutchinson, N.I.; Hagmann, W.K.; Cameron, P.M.; Boulton, D.A.; Hermes, J.D.
Human fibroblast stromelysin catalytic domain: expression, purification, and characterization of a C-terminally truncated form
Biochemistry
30
6476-6483
1991
Homo sapiens
Salowe, S.P.; Marcy, A.I.; Cuca, G.C.; Smith, C.K.; Kopka, I.E.; Hagmann, W.K.; Hermes, J.D.
Characterization of zinc-binding sites in human stromelysin-1: stoichiometry of the catalytic domain and identification of a cysteine ligand in the proenzyme
Biochemistry
31
4535-4540
1992
Homo sapiens
Ye, Q.Z.; Jonson, L.L.; Hupe, D.J.; Baragi, V.
Purification and characterization of the human stromelysin catalytic domain expressed in Escherichia coli
Biochemistry
31
11231-11235
1992
Homo sapiens
Baricos, W.H.; Murphy, G.; Zhou, Y.; Nguyen, H.H.; Shah, S.V.
Degradation of glomerular basement membrane by purified mammalian metalloproteinases
Biochem. J.
254
609-612
1988
Homo sapiens
Gunja-Smith, Z.; Nagase, H.; Woessner, J.F.
Purification of the neutral proteoglycan-degrading metalloproteinase from human articular cartilage tissue and its identification as stromelysin matrix metalloproteinase-3
Biochem. J.
258
115-119
1989
Oryctolagus cuniculus
Koklitis, P.A.; Murphy, G.; Sutton, C.; Angal, S.
Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activities
Biochem. J.
276
217-221
1991
Homo sapiens
Nagase, H.; Fields, C.G.; Fields, G.B.
Design and characterization of a fluorogenic substrate selectively hydrolyzed by stromelysin 1 (matrix metalloproteinase-3)
J. Biol. Chem.
269
20952-20957
1994
Homo sapiens
Becker, J.W.; Marcy, A.I.; Rokosz, L.L.; Axel, M.G.; Burbaum, J.J.; Fitzgerald, P.M.D.; Cameron, P.M.; Esser, C.K.; Hagmann, W.K.
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme
Protein Sci.
4
1966-1976
1995
Homo sapiens
Nagase, H.
Human stromelysins 1 and 2
Methods Enzymol.
248
449-470
1995
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Bini, A.; Wu, D.; Schnuer, J.; Kudryk, B.J.
Characterization of stromelysin 1 (MMP-3), matrilysin (MMP-7), and membrane type 1 matrix metalloproteinase (MT1-MMP) derived fibrin(ogen) fragments D-dimer and D-like monomer: NH2-terminal sequences of late-stage digest fragments
Biochemistry
38
13928-13936
1999
Homo sapiens
Heikkilae, P.; Teronen, O.; Moilanen, M.; Konttinen, Y.T.; Hanemaaijer, R.; Laitinen, M.; Maisi, P.; van der Pluijm, G.; Bartlett, J.D.; Salo, T.; Sorsa, T.
Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines
Anticancer Drugs
13
245-254
2002
Homo sapiens
Li, Y.C.; Zhang, X.; Melton, R.; Ganu, V.; Gonnella, N.C.
Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent, nonpeptidic inhibitor
Biochemistry
37
14048-14056
1998
Homo sapiens
Parker, M.H.; Lunney, E.A.; Ortwine, D.F.; Pavlovsky, A.G.; Humblet, C.; Brouillette, C.G.
Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry
Biochemistry
38
13592-13601
1999
Homo sapiens
Windsor, L.J.; Steele, D.L.; LeBlanc, S.B.; Taylor, K.B.
Catalytic domain comparisons of human fibroblast-type collagenase, stromelysin-1, and matrilysin
Biochim. Biophys. Acta
1334
261-272
1997
Homo sapiens
Johnson, L.L.; Pavlovsky, A.G.; Johnson, A.R.; Janowicz, J.A.; Man, C.F.; Ortwine, D.F.; Purchase, C.F.2nd.; White, A.D.; Hupe, D.J.
A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition
J. Biol. Chem.
275
11026-11033
2000
Homo sapiens
Agnihotri, R.; Crawford, H.C.; Haro, H.; Matrisian, L.M.; Havrda, M.C.; Liaw, L.
Osteopontin, a novel substrate for matrix metalloproteinase-3 (stromelysin-1) and matrix metalloproteinase-7 (matrilysin)
J. Biol. Chem.
276
28261-28267
2001
Homo sapiens
Esser, C.K.; Bugianesi, R.L.; Caldwell, C.G.; Chapman, K.T.; Durette, P.L.; Girotra, N.N.; Kopka, I.E.; Lanza, T.J.; Levorse, D.A.; MacCoss, M.; Owens, K.A.; Ponpipom, M.M.; Simeone, J.P.; Harrison, R.K.; Niedzwiecki, L.; Becker, J.W.; Marcy, A.I.; Axel, M.G.; Christen, A.J.; McDonnell, J.; Moore, V.L.; Olszewski, J.M.; Saphos, C.; Visco, D.M.; Hagmann, W.K.; et al.
Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides
J. Med. Chem.
40
1026-1040
1997
Mus musculus, Rattus norvegicus, Mus musculus C57Bl6/J
Ambrose Amin, E.; Welsh, W.J.
Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: applying a "divide and conquer" strategy
J. Med. Chem.
44
3849-3855
2001
Homo sapiens
Zhang, X.; Gonnella, N.C.; Koehn, J.; Pathak, N.; Ganu, V.; Melton, R.; Parker, D.; Hu, S.I.; Nam, K.Y.
Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1
J. Mol. Biol.
301
513-524
2000
Homo sapiens (P45452), Homo sapiens
Gomis-Rueth, F.X.; Maskos, K.; Betz, M.; Bergner, A.; Huber, R.; Suzuki, K.; Yoshida, N.; Nagase, H.; Brew, K.; Bourenkov, G.P.; Bartunik, H.; Bode, W.
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1
Nature
389
77-81
1997
Homo sapiens
del Mar Barbacid, M.; Fernandez-Resa, P.; Buesa, J.M.; Marquez, G.; Aracil, M.; Quesada, A.R.; Mira, E.
Expression and purification of human stromelysin 1 and 3 from baculovirus-infected insect cells
Protein Expr. Purif.
13
243-250
1998
Homo sapiens
Van Themsche, C.; Potworowski, E.F.; St-Pierre, Y.
Stromelysin-1 (MMP-3) is inducible in T lymphoma cells and accelerates the growth of lymphoid tumors in vivo
Biochem. Biophys. Res. Commun.
315
884-891
2004
Mus musculus
Kohno, T.; Hochigai, H.; Yamashita, E.; Tsukihara, T.; Kanaoka, M.
Crystal structures of the catalytic domain of human stromelysin-1 (MMP-3) and collagenase-3 (MMP-13) with a hydroxamic acid inhibitor SM-25453
Biochem. Biophys. Res. Commun.
344
315-322
2006
Homo sapiens
Huet, E.; Cauchard, J.; Berton, A.; Robinet, A.; Decarme, M.; Hornebeck, W.; Bellon, G.
Inhibition of plasmin-mediated prostromelysin-1 activation by interaction of long chain unsaturated fatty acids with kringle 5. [Erratum to document cited in CA140:297422]
Biochem. Pharmacol.
67
1011
2004
Homo sapiens
-
McCawley, L.J.; Crawford, H.C.; King, L.E.; Mudgett, J.; Matrisian, L.M.
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma
Cancer Res.
64
6965-6972
2004
Mus musculus
Chen, D.Y.; Lan, J.L.; Lin, F.J.; Hsieh, T.Y.
Elevated levels of soluble Fas (APO-1, CD95), soluble Fas ligand, and matrix metalloproteinase-3 in sera from patients with active untreated adult onset Stills disease
Clin. Rheumatol.
26
393-400
2007
Homo sapiens
Calabro, A.; Grappone, C.; Pellegrini, G.; Evangelista, S.; Tramontana, M.; Schuppan, D.; Herbst, H.; Milani, S.
Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing
Digestion
70
127-138
2004
Rattus norvegicus
Kim, H.J.; Fillmore, H.L.; Reeves, T.M.; Phillips, L.L.
Elevation of hippocampal MMP-3 expression and activity during trauma-induced synaptogenesis
Exp. Neurol.
192
60-72
2005
Rattus norvegicus
Lee, M.; Hadi, M.; Hallden, G.; Aponte, G.W.
Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity
J. Biol. Chem.
280
125-136
2005
Rattus norvegicus
Gonzalez-Cuevas, J.; Bueno-Topete, M.; Armendariz-Borunda, J.
Urokinase plasminogen activator stimulates function of active forms of stromelysin and gelatinases (MMP-2 and MMP-9) in cirrhotic tissue
J. Gastroenterol. Hepatol.
21
1544-1554
2006
Rattus norvegicus
Park, C.H.; Lee, M.J.; Ahn, J.; Kim, S.; Kim, H.H.; Kim, K.H.; Eun, H.C.; Chung, J.H.
Heat shock-induced matrix metalloproteinase (MMP)-1 and MMP-3 are mediated through ERK and JNK activation and via an autocrine interleukin-6 loop
J. Invest. Dermatol.
123
1012-1019
2004
Homo sapiens
Jacobsen, E.J.; Mitchell, M.A.; Hendges, S.K.; Belonga, K.L.; Skaletzky, L.L.; Stelzer, L.S.; Lindberg, T.J.; Fritzen, E.L.; Schostarez, H.J.; O’Sullivan, T.J.; Maggiora, L.L.; Stuchly, C.W.; Laborde, A.L.; Kubicek, M.F.; Poorman, R.A.; Beck, J.M.; Miller, H.R.; Petzold, G.L.; Scott, P.S.; Truesdell, S.E.; Wallace, T.L.; Wilks, J.W.; Fisher, C.; Goodman, L.V.; Kaytes, P.S.; Ledbetter, S.R.; Powers, E.A.
Synthesis of a series of stromelysin-selective thiadiazole urea matrix metalloproteinase inhibitors
J. Med. Chem.
42
1525-1536
1999
Homo sapiens
Rizzo, R.C.; Toba, S.; Kuntz, I.D.
A molecular basis for the selectivity of thiadiazole urea inhibitors with stromelysin-1 and gelatinase-A from generalized born molecular dynamics simulations
J. Med. Chem.
47
3065-3074
2004
Homo sapiens
Tas, F.; Duranyildiz, D.; Oguz, H.; Disci, R.; Kurul, S.; Yasasever, V.; Topuz, E.
Serum matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with malignant melanoma
Med. Oncol.
22
39-44
2005
Homo sapiens
Gurney, K.J.; Estrada, E.Y.; Rosenberg, G.A.
Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammation
Neurobiol. Dis.
23
87-96
2006
Mus musculus
Uzan, C.; Cortez, A.; Dufournet, C.; Fauvet, R.; Siffroi, J.P.; Darai, E.
Eutopic endometrium and peritoneal, ovarian and bowel endometriotic tissues express a different profile of matrix metalloproteinases-2, -3 and -11, and of tissue inhibitor metalloproteinases-1 and -2
Virchows Arch.
445
603-609
2004
Homo sapiens
Geurts, N.; Martens, E.; Van Aelst, I.; Proost, P.; Opdenakker, G.; Van den Steen, P.E.
Beta-hematin interaction with the hemopexin domain of gelatinase B/MMP-9 provokes autocatalytic processing of the propeptide, thereby priming activation by MMP-3
Biochemistry
47
2689-2699
2008
Homo sapiens
Jin, X.; Yagi, M.; Akiyama, N.; Hirosaki, T.; Higashi, S.; Lin, C.Y.; Dickson, R.B.; Kitamura, H.; Miyazaki, K.
Matriptase activates stromelysin (MMP-3) and promotes tumor growth and angiogenesis
Cancer Sci.
97
1327-1334
2006
Mus musculus
Meijer, M.J.; Mieremet-Ooms, M.A.; van der Zon, A.M.; van Duijn, W.; van Hogezand, R.A.; Sier, C.F.; Hommes, D.W.; Lamers, C.B.; Verspaget, H.W.
Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohns disease phenotype
Dig. Liver Dis.
39
733-739
2007
Homo sapiens
Fukuda, K.; Fujitsu, Y.; Kumagai, N.; Nishida, T.
Inhibition of matrix metalloproteinase-3 synthesis in human conjunctival fibroblasts by interleukin-4 or interleukin-13
Invest. Ophthalmol. Vis. Sci.
47
2857-2864
2006
Homo sapiens
Alcaraz, L.A.; Banci, L.; Bertini, I.; Cantini, F.; Donaire, A.; Gonnelli, L.
Matrix metalloproteinase-inhibitor interaction: the solution structure of the catalytic domain of human matrix metalloproteinase-3 with different inhibitors
J. Biol. Inorg. Chem.
12
1197-1206
2007
Homo sapiens
Sasanelli, R.; Boccarelli, A.; Giordano, D.; Laforgia, M.; Arnesano, F.; Natile, G.; Cardellicchio, C.; Capozzi, M.A.; Coluccia, M.
Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12
J. Med. Chem.
50
3434-3441
2007
Homo sapiens
Handley, S.A.; Miller, V.L.
General and specific host responses to bacterial infection in Peyers patches: a role for stromelysin-1 (matrix metalloproteinase-3) during Salmonella enterica infection
Mol. Microbiol.
64
94-110
2007
Mus musculus
Baillat, D.; Leprivier, G.; Regnier, D.; Vintonenko, N.; Begue, A.; Stehelin, D.; Aumercier, M.
Stromelysin-1 expression is activated in vivo by Ets-1 through palindromic head-to-head Ets binding sites present in the promoter
Oncogene
25
5764-5776
2006
Oryctolagus cuniculus
Bhuvarahamurthy, V.; Kristiansen, G.O.; Johannsen, M.; Loening, S.A.; Schnorr, D.; Jung, K.; Staack, A.
In situ gene expression and localization of metalloproteinases MMP1, MMP2, MMP3, MMP9, and their inhibitors TIMP1 and TIMP2 in human renal cell carcinoma
Oncol. Rep.
15
1379-1384
2006
Homo sapiens
Chen, C.; Lin, K.; Yu, D.T.; Yang, C.; Huang, F.; Chen, H.; Liang, T.; Liao, H.; Tsai, C.; Wei, J.C.; Chou, C.
Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity
Rheumatology
45
414-420
2006
Homo sapiens
Whitlock, G.A.; Dack. K.N.; Dickinson, R.P.; Lewis M.L
A novel series of highly selective inhibitors of MMP-3
Bioorg. Med. Chem. Lett.
17
6750-6753
2007
Homo sapiens
Irace, C.; Cortese, C.; Migale, M.; Liberatoscioli, L.; Mannucci, L.; Federici, G.; Gnasso, A.
Stromelysin gene promoter polymorphism and common carotid geometry in diabetic subjects
Int. Angiol.
27
413-418
2008
Homo sapiens
Juncker-Jensen, A.; Romer, J.; Pennington, C.J.; Lund, L.R.; Almholt, K.
Spontaneous metastasis in matrix metalloproteinase 3-deficient mice
Mol. Carcinog.
48
618-625
2009
Mus musculus
Chang, Y.W.; Oh, H.C.; Jang, J.Y.; Hwangbo, Y.; Lee, J.W.; Lee, H.J.; Joo, K.R.; Dong, S.H.; Kim, S.S.; Kim, H.J.; Kim, B.H.; Chang, R.
IL-1beta and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and after H. pylori eradication in gastroduodenal phenotypes
Scand. J. Gastroenterol.
43
1184-1193
2008
Homo sapiens
Phromnoi, K.; Yodkeeree, S.; Anuchapreeda, S.; Limtrakul, P.
Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids
Acta Pharmacol. Sin.
30
1169-1176
2009
Homo sapiens
Genevay, S.; Finckh, A.; Mezin, F.; Tessitore, E.; Guerne, P.A.
Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation
Arthritis Res. Ther.
11
R169
2009
Homo sapiens
Lijnen, H.R.; Van Hoef, B.; Rodriguez, J.A.; Paramo, J.A.
Stromelysin-2 (MMP-10) deficiency does not affect adipose tissue formation in a mouse model of nutritionally induced obesity
Biochem. Biophys. Res. Commun.
389
378-381
2009
Mus musculus
Lee, E.J.; Kim, S.Y.; Hyun, J.W.; Min, S.W.; Kim, D.H.; Kim, H.S.
Glycitein inhibits glioma cell invasion through down-regulation of MMP-3 and MMP-9 gene expression
Chem. Biol. Interact.
185
18-24
2010
Homo sapiens
Friese, R.S.; Rao, F.; Khandrika, S.; Thomas, B.; Ziegler, M.G.; Schmid-Schoenbein, G.W.; OConnor, D.T.
Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease
Clin. Exp. Hypertens.
31
521-533
2009
Homo sapiens
Pfaffen, S.; Hemmerle, T.; Weber, M.; Neri, D.
Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3
Exp. Cell Res.
316
836-847
2010
Mus musculus, Mus musculus Sv129
Komosinska-Vassev, K.; Olczyk, P.; Winsz-Szczotka, K.; Kuznik-Trocha, K.; Klimek, K.; Olczyk, K.
Age- and gender-dependent changes in connective tissue remodeling: physiological differences in circulating MMP-3, MMP-10, TIMP-1 and TIMP-2 Level
Gerontology
57
44-52
2010
Homo sapiens
Tuccinardi, T.; Ortore, G.; Santos, M.A.; Marques, S.M.; Nuti, E.; Rossello, A.; Martinelli, A.
Multitemplate alignment method for the development of a reliable 3D-QSAR model for the analysis of MMP3 inhibitors
J. Chem. Inf. Model.
49
1715-1724
2009
Homo sapiens
Green, J.A.; Elkington, P.T.; Pennington, C.J.; Roncaroli, F.; Dholakia, S.; Moores, R.C.; Bullen, A.; Porter, J.C.; Agranoff, D.; Edwards, D.R.; Friedland, J.S.
Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and activator protein-1-dependent monocyte networks
J. Immunol.
184
6492-6503
2010
Homo sapiens
Zeldich, E.; Koren, R.; Dard, M.; Weinberg, E.; Weinreb, M.; Nemcovsky, C.E.
Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signal-regulated kinase
J. Periodontal Res.
45
200-206
2010
Homo sapiens
Mun, S.H.; Kim, H.S.; Kim, J.W.; Ko, N.Y.; Kim, D.K.; Lee, B.Y.; Kim, B.; Won, H.S.; Shin, H.S.; Han, J.W.; Lee, H.Y.; Kim, Y.M.; Choi, W.S.
Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway
J. Pharmacol. Sci.
111
13-21
2009
Homo sapiens, Mus musculus, Mus musculus DBA/1J
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Husslein, H.; Haider, S.; Meinhardt, G.; Prast, J.; Sonderegger, S.; Knoefler, M.
Expression, regulation and functional characterization of matrix metalloproteinase-3 of human trophoblast
Placenta
30
284-291
2009
Homo sapiens
Johnson, J.L.; Dwivedi, A.; Somerville, M.; George, S.J.; Newby, A.C.
Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice
Arterioscler. Thromb. Vasc. Biol.
31
e35-e44
2011
Mus musculus
Howe, N.; Ceruso, M.; Spink, E.; Malthouse, J.P.
pH stability of the stromelysin-1 catalytic domain and its mechanism of interaction with a glyoxal inhibitor
Biochim. Biophys. Acta
1814
1394-1403
2011
Escherichia coli
Ceruso, M.; Howe, N.; Malthouse, J.P.
Mechanism of the binding of Z-L-tryptophan and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions
Biochim. Biophys. Acta
1824
303-310
2012
Homo sapiens (P08254)
Liang, X.; Arunima, A.; Zhao, Y.; Bhaskaran, R.; Shende, A.; Byrne, T.S.; Fleeks, J.; Palmier, M.O.; Van Doren, S.R.
Apparent tradeoff of higher activity in MMP-12 for enhanced stability and flexibility in MMP-3
Biophys. J.
99
273-283
2010
Homo sapiens
Segueni, N.; Magid, A.A.; Decarme, M.; Rhouati, S.; Lahouel, M.; Antonicelli, F.; Lavaud, C.; Hornebeck, W.
Inhibition of stromelysin-1 by caffeic acid derivatives from a propolis sample from Algeria
Planta Med.
77
999-1004
2011
Homo sapiens
Kundu, P.; De, R.; Pal, I.; Mukhopadhyay, A.; Saha, D.; Swarnakar, S.
Curcumin alleviates matrix metalloproteinase-3 and -9 activities during eradication of Helicobacter pylori infection in cultured cells and mice
PLoS ONE
6
e16306
2011
Homo sapiens, Mus musculus
Soliman, E.; Labib, W.; El-Tantawi, G.; Hamimy, A.; Alhadidy, A.; Aldawoudy, A.
Role of matrix metalloproteinase-3 (MMP-3) and magnetic resonance imaging of sacroiliitis in assessing disease activity in ankylosing spondylitis
Rheumatol. Int.
32
1711-1720
2011
Homo sapiens
Kim, E.M.; Shin, E.J.; Lee, J.A.; Son, H.J.; Choi, D.H.; Han, J.M.; Hwang, O.
Caspase-9 activation and Apaf-1 cleavage by MMP-3
Biochem. Biophys. Res. Commun.
453
563-568
2014
Homo sapiens (P08254)
Wilfong, E.M.; Du, Y.; Toone, E.J.
An enthalpic basis of additivity in biphenyl hydroxamic acid ligands for stromelysin-1
Bioorg. Med. Chem. Lett.
22
6521-6524
2012
Homo sapiens (P08254)
Khaddam, M.; Salmon, B.; Le Denmat, D.; Tjaderhane, L.; Menashi, S.; Chaussain, C.; Rochefort, G.Y.; Boukpessi, T.
Grape seed extracts inhibit dentin matrix degradation by MMP-3
Front. Physiol.
5
425
2014
Homo sapiens (P08254)
Ijichi, K.; Brown, G.D.; Moore, C.S.; Lee, J.P.; Winokur, P.N.; Pagarigan, R.; Snyder, E.Y.; Bongarzone, E.R.; Crocker, S.J.
MMP-3 mediates psychosine-induced globoid cell formation: implications for leukodystrophy pathology
Glia
61
765-777
2013
Mus musculus (P28862), Mus musculus, Mus musculus C57BL/6 (P28862)
Batra, J.; Robinson, J.; Soares, A.; Fields, A.; Radisky, D.; Radisky, E.
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: Binding studies and crystal structure
J. Biol. Chem.
287
15935-15946
2012
Homo sapiens (P08254), Homo sapiens
Mehner, C.; Miller, E.; Khauv, D.; Nassar, A.; Oberg, A.L.; Bamlet, W.R.; Zhang, L.; Waldmann, J.; Radisky, E.S.; Crawford, H.C.; Radisky, D.C.
Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma
Mol. Cancer Res.
12
1430-1439
2014
Homo sapiens (P08254)
Peng, M.; Jia, J.; Qin, W.
Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for Alzheimer disease
Neurosci. Lett.
595
116-121
2015
Homo sapiens (P08254), Homo sapiens
Zuo, X.; Pan, W.; Feng, T.; Shi, X.; Dai, J.
Matrix metalloproteinase 3 promotes cellular anti-Dengue virus response via interaction with transcription factor NFkappaB in cell nucleus
PLoS ONE
9
e84748
2014
Homo sapiens (P08254), Homo sapiens
Jerah, A.; Hobani, Y.; Kumar, B.V.; Bidwai, A.
Curcumin binds in silico to anti-cancer drug target enzyme MMP-3 (human stromelysin-1) with affinity comparable to two known inhibitors of the enzyme
Bioinformation
11
387-392
2015
Homo sapiens (P08254)
Mirastschijski, U.; Dinesh, N.; Baskaran, S.; Wedekind, D.; Gavrilovic, J.; Murray, M.Y.; Bevan, D.; Kelm, S.
Novel specific human and mouse stromelysin-1 (MMP-3) and stromelysin-2 (MMP-10) antibodies for biochemical and immunohistochemical analyses
Wound Repair Regen.
27
309-323
2019
Mus musculus (P28862), Mus musculus, Mus musculus BL10 (P28862)
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