3.4.24.17: stromelysin 1
This is an abbreviated version!
For detailed information about stromelysin 1, go to the full flat file.
Word Map on EC 3.4.24.17
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3.4.24.17
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metalloproteinases
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mmp-1
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cartilage
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arthritis
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joint
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osteoarthritis
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rheumatoid
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synovial
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chondrocytes
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necrosis
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timps
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articular
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gelatinase
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tnf
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interleukin-1
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knee
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zymography
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degeneration
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aggrecan
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proteoglycans
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c-reactive
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interstitial
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gelatin
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plasminogen
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proteinases
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cox-2
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synoviocytes
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il-1beta
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fibroblast-like
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cruciate
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intervertebral
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ligament
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matrilysin
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pulposus
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matrix-degrading
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adamts-4
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synovitis
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thrombospondin
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intra-articular
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subchondral
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emmprin
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chondroprotective
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photoaging
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collagenases
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diagnostics
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medicine
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aggrecanase
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prommp-9
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neoepitope
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gelatinolytic
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mt1-mmp
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collagenolytic
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drug development
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analysis
- 3.4.24.17
- metalloproteinases
- mmp-1
- cartilage
- arthritis
- joint
- osteoarthritis
-
rheumatoid
- synovial
- chondrocytes
- necrosis
- timps
-
articular
- gelatinase
- tnf
- interleukin-1
- knee
-
zymography
- degeneration
- aggrecan
- proteoglycans
-
c-reactive
-
interstitial
- gelatin
- plasminogen
- proteinases
- cox-2
- synoviocytes
- il-1beta
-
fibroblast-like
-
cruciate
-
intervertebral
- ligament
- matrilysin
- pulposus
-
matrix-degrading
- adamts-4
- synovitis
- thrombospondin
-
intra-articular
-
subchondral
-
emmprin
-
chondroprotective
-
photoaging
- collagenases
- diagnostics
- medicine
- aggrecanase
-
prommp-9
-
neoepitope
-
gelatinolytic
- mt1-mmp
-
collagenolytic
- drug development
- analysis
Reaction
preferential cleavage where P1', P2' and P3' are hydrophobic residues =
Synonyms
Collagen-activating protein, Collagenase activating protein, matrix metalloprotease-3, Matrix metalloproteinase 3, matrix metalloproteinase-3, matrixin, MMP-3, MMP3, Neutral proteoglycanase, Procollagenase activator, Proteoglycanase, PTR1 protein, ST1, Stromelysin, stromelysin-1, Transin
ECTree
3.4.24.17 stromelysin 1Advanced search results
results (
results (Molecular Weight
Molecular Weight on EC 3.4.24.17 - stromelysin 1
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MOLECULAR WEIGHT 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
45000
57000
additional information
additional information
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prostromelysin expressed in a mouse fibroblast cell line C127 self activates by incubation at 55°C to a 45000 MW and a 28000 MW form
additional information
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stromelysin 1 is synthesized as a preproenzyme of 477 amino acids and is secreted from cells as a proenzyme of 460 amino acids which consist of the propeptide (82 amino acids), the catalytic domain (165 amino acids), the proline-rich region (25 amino acids), and the C-terminal domain (188 amino acids)
additional information
-
stromelysin 1 is synthesized as a preproenzyme of 477 amino acids and is secreted from cells as a proenzyme of 460 amino acids which consist of the propeptide (82 amino acids), the catalytic domain (165 amino acids), the proline-rich region (25 amino acids), and the C-terminal domain (188 amino acids)
additional information
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proenzyme form of 51000 MW is activated during isolation to several forms: 41000 MW form after treatment with trypsin or 4-aminophenylmercuric acetate, active forms of MW 21000-25000 and the activatable form of MW 35000
