3.4.24.17: stromelysin 1

This is an abbreviated version!
For detailed information about stromelysin 1, go to the full flat file.

Word Map on EC 3.4.24.17

3.4.24.17

metalloproteinases

mmp-1

cartilage

arthritis

joint

osteoarthritis

rheumatoid

synovial

chondrocytes

necrosis

timps

articular

gelatinase

tnf

interleukin-1

knee

zymography

degeneration

aggrecan

proteoglycans

c-reactive

interstitial

gelatin

plasminogen

proteinases

cox-2

synoviocytes

il-1beta

fibroblast-like

cruciate

intervertebral

ligament

matrilysin

pulposus

matrix-degrading

adamts-4

synovitis

thrombospondin

intra-articular

subchondral

emmprin

chondroprotective

photoaging

collagenases

diagnostics

medicine

aggrecanase

prommp-9

neoepitope

gelatinolytic

mt1-mmp

collagenolytic

drug development

analysis

Reaction

preferential cleavage where P1', P2' and P3' are hydrophobic residues =

Synonyms

Collagen-activating protein, Collagenase activating protein, matrix metalloprotease-3, Matrix metalloproteinase 3, matrix metalloproteinase-3, matrixin, MMP-3, MMP3, Neutral proteoglycanase, Procollagenase activator, Proteoglycanase, PTR1 protein, ST1, Stromelysin, stromelysin-1, Transin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.17 stromelysin 1

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Results	in table
8	Activating Compound
15	AA Sequence
22	Application
1	CAS Registry Number
11	Cloned(Commentary)
5	Crystallization (Commentary)
7657	Disease/ Diagnostics
22	Expression
30	General Information
4	General Stability
42	IC50 Value
273	Inhibitors
6	kcat/KM [mM/s]
76	Ki Value [mM]
11	KM Value [mM]
25	Localization
35	Metals/Ions
12	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
105	Organism
70	PDB ID
15	pH Optimum
3	pH Range
11	pH Stability
2	Posttranslational Modification
14	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
88	Source Tissue
12	Specific Activity [micromol/min/mg]
5	Storage Stability
142	Substrates and Products (Substrate)
7	Subunits
109	Synonyms
12	Temperature Optimum [°C]
5	Temperature Stability [°C]
10	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.24.17 - stromelysin 1

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0.066

(7-Methoxycoumarin-4-yl)acetyl-Arg-Pro-Lys-Pro-Tyr-Ala-norvaline-Trp-Met-Lys(2,4-dinitrophenyl)-NH2

Homo sapiens

31015

0.025

(7-Methoxycoumarin-4-yl)acetyl-Arg-Pro-Lys-Pro-Val-Glu-norvaline-Trp-Arg-Lys(2,4-dinitrophenyl)-NH2

Homo sapiens

31015, 31017

0.05

(7-Methoxycoumarin-4-yl)acetyl-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Lys-(2,4-dinitrophenyl)-Gly

Homo sapiens

31015

0.1

2,4-Dinitrophenyl-Pro-Tyr-Ala-Tyr-Trp-Met-Arg-NH2

Homo sapiens

31015, 31017

0.27

acetyl-Pro-Leu-Gly-thioester-Leu-Leu-Gly-ethylester

Homo sapiens

31012

0.395

acetyl-Pro-Leu-Gly-[2-mercapto-4-methyl-pentanoyl]-Leu-Gly-OC2H5

Escherichia coli

pH 6.0, 25°C, catalytic domain (residues 83-247)

717280

0.9 - 1.4

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-norleucine-NH2

2 entries

additional information

Homo sapiens

P08254

thermodynamic additivity analysis using stromelysin-1 and a series of biphenyl hydroxamate ligands identified through fragment additivity, thermodynamics determined by isothermal titration calorimetry, corrected for proton transfer events, overview. Additivity arises from enthalpic effects, while interaction entropies are unfavorable, the thermodynamic behavior is masked by proton transfer

733479