3.4.24.17: stromelysin 1

This is an abbreviated version!
For detailed information about stromelysin 1, go to the full flat file.

Word Map on EC 3.4.24.17

3.4.24.17

metalloproteinases

mmp-1

cartilage

arthritis

joint

osteoarthritis

rheumatoid

synovial

chondrocytes

necrosis

timps

articular

gelatinase

tnf

interleukin-1

knee

zymography

degeneration

aggrecan

proteoglycans

c-reactive

interstitial

gelatin

plasminogen

proteinases

cox-2

synoviocytes

il-1beta

fibroblast-like

cruciate

intervertebral

ligament

matrilysin

pulposus

matrix-degrading

adamts-4

synovitis

thrombospondin

intra-articular

subchondral

emmprin

chondroprotective

photoaging

collagenases

diagnostics

medicine

aggrecanase

prommp-9

neoepitope

gelatinolytic

mt1-mmp

collagenolytic

drug development

analysis

Reaction

preferential cleavage where P1', P2' and P3' are hydrophobic residues =

Synonyms

Collagen-activating protein, Collagenase activating protein, matrix metalloprotease-3, Matrix metalloproteinase 3, matrix metalloproteinase-3, matrixin, MMP-3, MMP3, Neutral proteoglycanase, Procollagenase activator, Proteoglycanase, PTR1 protein, ST1, Stromelysin, stromelysin-1, Transin

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.17 stromelysin 1

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Results	in table
8	Activating Compound
15	AA Sequence
22	Application
1	CAS Registry Number
11	Cloned(Commentary)
5	Crystallization (Commentary)
7657	Disease/ Diagnostics
22	Expression
30	General Information
4	General Stability
42	IC50 Value
273	Inhibitors
6	kcat/KM [mM/s]
76	Ki Value [mM]
11	KM Value [mM]
25	Localization
35	Metals/Ions
12	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
105	Organism
70	PDB ID
15	pH Optimum
3	pH Range
11	pH Stability
2	Posttranslational Modification
14	Protein Variants
19	Purification (Commentary)
1	Reaction
1	Reaction Type
98	Reference
88	Source Tissue
12	Specific Activity [micromol/min/mg]
5	Storage Stability
142	Substrates and Products (Substrate)
7	Subunits
109	Synonyms
12	Temperature Optimum [°C]
5	Temperature Stability [°C]
10	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.24.17 - stromelysin 1

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0.0000004

2-([4-[3'-(2-aminoethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-N-hydroxy-2-methylpropanamide

Homo sapiens

691260

0.000164

2-[(2-biphenyl-4-ylethyl)(methyl)sulfamoyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000161

2-[(3-biphenyl-4-ylazetidin-1-yl)sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000174

2-[(3-biphenyl-4-ylpropyl)(methyl)sulfamoyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000006

2-[(4-biphenyl-4-yl-3,6-dihydropyridin-1(2H)-yl)sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000026

2-[(4-biphenyl-4-ylpiperidin-1-yl)sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000001

2-[(4-[3'-[2-(dimethylamino)ethoxy]-2-methylbiphenyl-4-yl]piperidin-1-yl)sulfonyl]-N-hydroxy-2-methylpropanamide

Homo sapiens

691260

0.000378

2-[(biphenyl-4-ylmethyl)(methyl)sulfamoyl]-N-hydroxyacetamide

Homo sapiens

691260

0.00043

2-[(biphenyl-4-ylsulfonyl)[2-(hydroxyamino)-2-oxoethyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide

Homo sapiens

pH 7.5, 25°C

709255

0.00014

2-[[2-(hydroxyamino)-2-oxoethyl][(4-methoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide

Homo sapiens

pH 7.5, 25°C

709255

0.0000061

2-[[2-(hydroxyamino)-2-oxoethyl][(4-phenoxyphenyl)sulfonyl]amino]-N-[2-(4-sulfamoylphenyl)ethyl]acetamide

Homo sapiens

pH 7.5, 25°C

709255

0.000084

2-[[3-(biphenyl-4-yloxy)azetidin-1-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000004

2-[[4-(2,3'-dimethylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000055

2-[[4-(2-chlorobiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000402

2-[[4-(2-ethylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000003

2-[[4-(2-fluorobiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000004

2-[[4-(3'-ethoxy-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.000002

2-[[4-(3'-ethoxy-2-methylbiphenyl-4-yl)piperidin-1-yl]sulfonyl]-N-hydroxy-2-methylpropanamide

Homo sapiens

691260

0.000031

2-[[4-(3'-ethyl-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]-N-hydroxyacetamide

Homo sapiens

691260

0.00063

chicoric acid

Homo sapiens

pH and temperature not specified in the publication

718242

0.3

clodronate

Homo sapiens

688251

0.0053

dichloro[[(methylsulfinyl-kappaS)methyl]phosphonate-kappaO'']platinum

Homo sapiens

688251

0.000127

N-(biphenyl-4-ylsulfonyl)-N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]glycine

Homo sapiens

pH 7.5, 25°C

709255

0.00096

N-hydroxy-2-([4-[2-(trifluoromethyl)biphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide

Homo sapiens

691260

0.000051

N-hydroxy-2-([4-[2-methyl-3'-(trifluoromethoxy)biphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide

Homo sapiens

691260

0.000001

N-hydroxy-2-([4-[3'-(2-hydroxyethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-2-methylpropanamide

Homo sapiens

691260

0.000003

N-hydroxy-2-([4-[3'-(2-methoxyethoxy)-2-methylbiphenyl-4-yl]piperidin-1-yl]sulfonyl)-2-methylpropanamide

Homo sapiens

691260

0.000003

N-hydroxy-2-([4-[3'-(methoxymethyl)-2-methylbiphenyl-4-yl]-3,6-dihydropyridin-1(2H)-yl]sulfonyl)acetamide

Homo sapiens

691260

0.0000003

N-hydroxy-2-methyl-2-[(4-[2-methyl-3'-[2-(methylamino)ethoxy]biphenyl-4-yl]piperidin-1-yl)sulfonyl]propanamide

Homo sapiens

691260

0.000001

N-hydroxy-2-[(4-[4-[6-(2-hydroxyethoxy)pyridin-2-yl]-3-methylphenyl]piperidin-1-yl)sulfonyl]-2-methylpropanamide

Homo sapiens

691260

0.000016

N-hydroxy-2-[[4-(2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]acetamide

Homo sapiens

691260

0.000005

N-hydroxy-2-[[4-(3'-methoxy-2-methylbiphenyl-4-yl)-3,6-dihydropyridin-1(2H)-yl]sulfonyl]acetamide

Homo sapiens

691260

0.000205

N-hydroxy-2-[[4-(4-phenoxyphenyl)piperidin-1-yl]sulfonyl]acetamide

Homo sapiens

691260

0.000163

N-hydroxy-3-(hydroxymethyl)-1-[(4-methoxyphenyl)sulfonyl]-4,4-dimethylprolinamide

Homo sapiens

pH 7.5, 25°C

709255

0.000182

N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-methoxyphenyl)sulfonyl]glycine

Homo sapiens

pH 7.5, 25°C

709255

0.0000067

N-[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-N-[(4-phenoxyphenyl)sulfonyl]glycine

Homo sapiens

pH 7.5, 25°C

709255

0.00002

N-[4-(hydroxycarbamoyl)-1-(methoxymethoxy)-7,7-dimethyl-6-oxooctan-2-yl]-4-phenoxybenzamide

Homo sapiens

pH 7.5, 25°C

709255

0.0000372

N-[5-(hydroxyamino)-1-(methoxymethoxy)-4-methyl-5-oxopentan-2-yl]-4-phenoxybenzamide

Homo sapiens

pH 7.5, 25°C

709255

0.0000012

N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxo-4-(pyridin-2-ylmethyl)pentan-2-yl]-4-phenoxybenzamide

Homo sapiens

pH 7.5, 25°C

709255

0.00138

N-[5-(hydroxyamino)-1-(methoxymethoxy)-5-oxopentan-2-yl]-4-phenoxybenzamide

Homo sapiens

pH 7.5, 25°C

709255

0.000023

UK-370106

Homo sapiens

691260

0.0044

[dimethylpropanedioato(2-)-kappa2O1,O3][[(methylsulfinyl-kappaS)methyl]phosphonate-kappaO''']platinum

Homo sapiens

688251