3.4.24.16: neurolysin

This is an abbreviated version!
For detailed information about neurolysin, go to the full flat file.

Word Map on EC 3.4.24.16

3.4.24.16

bradykinin

metallopeptidase

metalloendopeptidase

dynorphins

pro-ile

neuropeptidase

pro10-tyr11

neuromedin

hemopressins

arg8-arg9

non-at2

neurotensin-degrading

molecular biology

pharmacology

medicine

Reaction

Preferential cleavage in neurotensin: Pro10-/-Tyr =

Synonyms

endopeptidase 24.16, endopeptidase 24.16B, endopeptidase 3.4.24.16, EP 24.16, ep24.16, EP24.16c, EP24.16m, MEP, Microsomal endopeptidase, mitochondrial peptidase, MOP, More, NEL, neurolisin, neurolysin, neurotensin endopeptidase, neurotensin-cleaving enzyme, Nln, oligopeptidase M, peptidase, neurotensin endo, peptidase, neurotensin endo-, SABP, soluble angiotensin II-binding protein, Soluble angiotensin-binding protein, thimet oligopeptidase II, thimet peptidase II

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.16 neurolysin

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Results	in table
3	Activating Compound
26	AA Sequence
5	Application
2	CAS Registry Number
21	Cloned(Commentary)
6	Crystallization (Commentary)
77	Disease/ Diagnostics
4	Expression
17	General Information
3	General Stability
2	IC50 Value
196	Inhibitors
11	Ki Value [mM]
167	KM Value [mM]
46	Localization
24	Metals/Ions
12	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
202	Organism
8	PDB ID
8	pH Optimum
1	pH Range
3	Posttranslational Modification
17	Protein Variants
15	Purification (Commentary)
1	Reaction
2	Reaction Type
63	Reference
130	Source Tissue
13	Specific Activity [micromol/min/mg]
1	Storage Stability
343	Substrates and Products (Substrate)
13	Subunits
56	Synonyms
7	Temperature Optimum [°C]
207	Turnover Number [1/s]

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Turnover Number on EC 3.4.24.16 - neurolysin

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0.76 - 1.1

(7-methoxy-coumarin-4-yl)acetyl-RPKPVE-Nva-WRK(2,4-dinitrophenyl)-NH2

show

1.9 - 2.1

(7-methoxy-coumarin-4-yl)acetyl-RPKPYA-Nva-WMK(2,4-dinitrophenyl)-NH2

show

11.9

(7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Ile-Arg-Arg-Ala-Lys-dinitrophenyl

Rattus norvegicus

-

-

2.1

(7-methoxycoumarin-4-yl)acetyl-Gly-Gly-Phe-Leu-Arg-Arg-Ala-Lys-dinitrophenyl

Rattus norvegicus

-

-

0.1 - 0.27

(o-aminobenzoyl)-AFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.00497

(o-aminobenzoyl)-AKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.02 - 0.12

(o-aminobenzoyl)-DFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.01 - 0.08

(o-aminobenzoyl)-EFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

1.35

(o-aminobenzoyl)-ENKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.03 - 0.23

(o-aminobenzoyl)-FFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

1.3

(o-aminobenzoyl)-GASPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.34

(o-aminobenzoyl)-GDSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.84 - 6.08

(o-aminobenzoyl)-GESPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.8

(o-aminobenzoyl)-GFAPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.2

(o-aminobenzoyl)-GFDPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.07

(o-aminobenzoyl)-GFEPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.28 - 6.08

(o-aminobenzoyl)-GFFPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.52 - 6.08

(o-aminobenzoyl)-GFHPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.27

(o-aminobenzoyl)-GFIPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.24

(o-aminobenzoyl)-GFLPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.64 - 6.08

(o-aminobenzoyl)-GFNPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.62 - 6.08

(o-aminobenzoyl)-GFPPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.39

(o-aminobenzoyl)-GFQPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.97 - 6.08

(o-aminobenzoyl)-GFRPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

2.6

(o-aminobenzoyl)-GFSAFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

2.5

(o-aminobenzoyl)-GFSDFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.19

(o-aminobenzoyl)-GFSEFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

3.4

(o-aminobenzoyl)-GFSFFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

4.8

(o-aminobenzoyl)-GFSHFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.22

(o-aminobenzoyl)-GFSIFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

3.5

(o-aminobenzoyl)-GFSLFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

8.8

(o-aminobenzoyl)-GFSNFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.4

(o-aminobenzoyl)-GFSPARQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-X bond

0.03 - 0.24

(o-aminobenzoyl)-GFSPDRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.14 - 0.65

(o-aminobenzoyl)-GFSPERQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

1.3 - 1.4

(o-aminobenzoyl)-GFSPFAQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

1.8

(o-aminobenzoyl)-GFSPFDQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of F-S bond

0.29 - 1.6

(o-aminobenzoyl)-GFSPFEQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.4 - 1.4

(o-aminobenzoyl)-GFSPFFQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.88 - 6.08

(o-aminobenzoyl)-GFSPFHQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.61 - 6.08

(o-aminobenzoyl)-GFSPFIQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

5.9

(o-aminobenzoyl)-GFSPFLQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-F bond

0.64 - 6.08

(o-aminobenzoyl)-GFSPFNQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

1.4

(o-aminobenzoyl)-GFSPFPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-F bond

0.56 - 6.08

(o-aminobenzoyl)-GFSPFQQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

3

(o-aminobenzoyl)-GFSPFRA-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.1

(o-aminobenzoyl)-GFSPFRE-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.8

(o-aminobenzoyl)-GFSPFRF-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.9

(o-aminobenzoyl)-GFSPFRI-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

7.4

(o-aminobenzoyl)-GFSPFRL-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.9

(o-aminobenzoyl)-GFSPFRN-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

0.83 - 6.08

(o-aminobenzoyl)-GFSPFRP-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.31

(o-aminobenzoyl)-GFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.45

(o-aminobenzoyl)-GFSPFRR-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

2.1

(o-aminobenzoyl)-GFSPFRS-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.1 - 1.3

(o-aminobenzoyl)-GFSPFSQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.19

(o-aminobenzoyl)-GFSPHRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-X bond

0.53 - 6.08

(o-aminobenzoyl)-GFSPIRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.55 - 1.3

(o-aminobenzoyl)-GFSPLRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.62 - 6.08

(o-aminobenzoyl)-GFSPNRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.15

(o-aminobenzoyl)-GFSPPRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-X bond

2.6

(o-aminobenzoyl)-GFSPQRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-X bond

0.42

(o-aminobenzoyl)-GFSPRRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-X bond

1.5

(o-aminobenzoyl)-GFSPSRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-X bond

0.67 - 6.08

(o-aminobenzoyl)-GFSQFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.31

(o-aminobenzoyl)-GFSRFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

7.5

(o-aminobenzoyl)-GFSSFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

3.6

(o-aminobenzoyl)-GFSXFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.77 - 2.94

(o-aminobenzoyl)-GGFLPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

3.2

(o-aminobenzoyl)-GGFLRRAQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

1

(o-aminobenzoyl)-GGFLRRDQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

1.1

(o-aminobenzoyl)-GGFLRREQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

0.2 - 0.3

(o-aminobenzoyl)-GGFLRRFQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.6 - 1.6

(o-aminobenzoyl)-GGFLRRHQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.1 - 0.7

(o-aminobenzoyl)-GGFLRRIQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.2 - 0.5

(o-aminobenzoyl)-GGFLRRLQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.3 - 0.6

(o-aminobenzoyl)-GGFLRRNQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

1.8

(o-aminobenzoyl)-GGFLRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

3.3

(o-aminobenzoyl)-GGFLRRRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

2

(o-aminobenzoyl)-GGFLRRV-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

1.4

(o-aminobenzoyl)-GGFLRRVQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4. 37°C, cleavage of the R-R bond

0.2 - 0.3

(o-aminobenzoyl)-GGFLRRYQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.95

(o-aminobenzoyl)-GHSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

2.6

(o-aminobenzoyl)-GISPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

6.2

(o-aminobenzoyl)-GLSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.3

(o-aminobenzoyl)-GNSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

2.2

(o-aminobenzoyl)-GPSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.9

(o-aminobenzoyl)-GQSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

5.4

(o-aminobenzoyl)-GRSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

2

(o-aminobenzoyl)-GSSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C

1.2

(o-aminobenzoyl)-HFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 7.4, 37°C, cleavage of P-F bond

0.05 - 0.45

(o-aminobenzoyl)-IFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

2.63 - 6

(o-aminobenzoyl)-KPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.13 - 0.35

(o-aminobenzoyl)-LFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

3.8

(o-aminobenzoyl)-LYENKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00697

(o-aminobenzoyl)-NAPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.16 - 1

(o-aminobenzoyl)-NFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.00576

(o-aminobenzoyl)-NKARRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00123

(o-aminobenzoyl)-NKPARPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.014

(o-aminobenzoyl)-NKPRAPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.00124

(o-aminobenzoyl)-NKPRRAQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

7

(o-aminobenzoyl)-NKPRRPQ-(N-(2,4-dinitrophenyl)ethylenediamine)

-

pH 8.0, 37°C, hydrolysis of R-R bond

0.12 - 0.39

(o-aminobenzoyl)-QFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.02 - 0.27

(o-aminobenzoyl)-RFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.12 - 6.08

(o-aminobenzoyl)-SFSPFRQ-(N-(2,4-dinitrophenyl)ethylenediamine)

show

0.006 - 0.3

2-aminobenzoyl-GFSPFRQ-(N-2,4-dinitrophenyl)ethylenediamine

show

0.2 - 2.6

Abz-GFSAFRQEDDnp

show

0.1 - 1.2

Abz-GFSEFRQEDDnp

show

0.09 - 4.9

Abz-GFSFFRQEDDnp

show

0.05 - 6.3

Abz-GFSHFRQEDDnp

show

0.01 - 0.2

Abz-GFSIFRQEDDnp

show

0.1 - 3.5

Abz-GFSLFRQEDDnp

show

0.6 - 5.9

Abz-GFSQFRQEDDnp

show

0.4 - 4.8

Abz-GFSRFRQEDDnp

show

0.06 - 7.5

Abz-GFSSFRQEDDnp

show

0.3 - 2.4

Abz-GFSWFRQEDDnp

show

0.3 - 4.1

Abz-GFSyFRQEDDnp

show

2.8 - 5

neurotensin

show

0.827

Tyr-Gly-Gly-Phe-Leu-Arg

Rattus norvegicus

-

-

1.94

Tyr-Gly-Gly-Phe-Leu-Arg-Arg

Rattus norvegicus

-

-

2.52

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile

Rattus norvegicus

-

-

1.5

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg

Rattus norvegicus

-

-

additional information

additional information

Rattus norvegicus

-

turnover-numbers for the reaction with angiotensin I analogs

-

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Release 2023.1 (January 2023)