3.4.24.16: neurolysin

This is an abbreviated version!
For detailed information about neurolysin, go to the full flat file.

Word Map on EC 3.4.24.16

3.4.24.16

bradykinin

metallopeptidase

metalloendopeptidase

dynorphins

pro-ile

neuropeptidase

pro10-tyr11

neuromedin

hemopressins

arg8-arg9

non-at2

neurotensin-degrading

molecular biology

pharmacology

medicine

Reaction

Preferential cleavage in neurotensin: Pro10-/-Tyr =

Synonyms

endopeptidase 24.16, endopeptidase 24.16B, endopeptidase 3.4.24.16, EP 24.16, ep24.16, EP24.16c, EP24.16m, MEP, Microsomal endopeptidase, mitochondrial peptidase, MOP, More, NEL, neurolisin, neurolysin, neurotensin endopeptidase, neurotensin-cleaving enzyme, Nln, oligopeptidase M, peptidase, neurotensin endo, peptidase, neurotensin endo-, SABP, soluble angiotensin II-binding protein, Soluble angiotensin-binding protein, thimet oligopeptidase II, thimet peptidase II

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.16 neurolysin

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Results	in table
3	Activating Compound
26	AA Sequence
5	Application
2	CAS Registry Number
21	Cloned(Commentary)
6	Crystallization (Commentary)
77	Disease/ Diagnostics
4	Expression
17	General Information
3	General Stability
2	IC50 Value
196	Inhibitors
11	Ki Value [mM]
167	KM Value [mM]
46	Localization
24	Metals/Ions
12	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
202	Organism
8	PDB ID
8	pH Optimum
1	pH Range
3	Posttranslational Modification
17	Protein Variants
15	Purification (Commentary)
1	Reaction
2	Reaction Type
63	Reference
130	Source Tissue
13	Specific Activity [micromol/min/mg]
1	Storage Stability
343	Substrates and Products (Substrate)
13	Subunits
56	Synonyms
7	Temperature Optimum [°C]
207	Turnover Number [1/s]

Synonyms

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Synonyms on EC 3.4.24.16 - neurolysin

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endopeptidase 24.16

2 entries

endopeptidase 24.16B

endopeptidase 3.4.24.16

EP 24.16

ep24.16

EP24.16c

the cytosolic/membrane bound enzyme form

37061

EP24.16m

Sus scrofa

the mitochondrial enzyme form

37061

MEP

Microsomal endopeptidase

2 entries

mitochondrial peptidase

Homo sapiens

Q9BYT8

754429

MOP

NEL

neurolisin

neurolysin

neurotensin endopeptidase

neurotensin-cleaving enzyme

6 entries

Nln

6 entries

oligopeptidase M

2 entries

peptidase, neurotensin endo

peptidase, neurotensin endo-

SABP

soluble angiotensin II-binding protein

Rattus norvegicus

668828

Soluble angiotensin-binding protein

thimet oligopeptidase II

Rattus norvegicus

neurolysin is most likely to be confused with thimet oligopeptidase II, but it is distinguished by its lack of activation by thiol compounds, inhibition by millimolar concentrations of Pro-Ile, cleavage of neurotensin at the Pro-Tyr bond, and different mobility in column chromatography

thimet peptidase II

ep24.16