3.4.24.14: procollagen N-endopeptidase
This is an abbreviated version!
For detailed information about procollagen N-endopeptidase, go to the full flat file.
Word Map on EC 3.4.24.14 
Reaction
Cleaves the N-propeptide of collagen chain alpha1(I) at Pro-/-Gln and of alpha1(II) and alpha2(I) at Ala-/-Gln
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Synonyms
ADAM-TS2, ADAMTS 3, ADAMTS proteinase, ADAMTS-2, ADAMTS14, ADAMTS2, ADAMTS3, aminoprocollagen endopeptidase, aminoprocollagen peptidase, aminoterminal procollagen peptidase, PC I-NP, pNPI, procollagen ADAMTS, procollagen aminopeptidase, procollagen aminoterminal protease, Procollagen I N-proteinase, Procollagen I/II amino-propeptide processing enzyme, procollagen I/II N-endopeptidase, procollagen III N-endopeptidase, procollagen III N-proteinase, Procollagen N-endopeptidase, procollagen N-protease, procollagen N-proteinase, procollagen N-terminal peptidase, procollagen N-terminal proteinase, Procollagen peptidase, type I/II procollagen N-proteinase
ECTree
Inhibitors
Inhibitors on EC 3.4.24.14 - procollagen N-endopeptidase
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alpha2-Macroglobulin
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-
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ammonium persulfate
-
94% inhibition at 10 micromol/ml
decanoyl-Arg-Val-Lys-Arg-chloromethylketone
-
-
ferrocene derivatives
-
-
-
metal chelator
-
potent inhibitor
-
NaCl
-
40% inhibition at 0.3 M
p-hydroxymercuribenzoate
-
-
Reducing agent
-
potent inhibitor
-
TIMP-3
-
inhibits ADAMTS-2 in vitro in the presence of procollagen I and II, addition of heparin enhances the ability of TIMP-3 to inhibit the enzyme
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Tris-HCl
-
80% inhibition at 0.3 M
1,10-phenanthroline
-
-
1,10-phenanthroline
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100% inhibition at 1 mM
1,10-phenanthroline
-
100% inhibition at 1 mM
1,10-phenanthroline
-
45% inhibition at 0.1 mM
2,2'-dipyridyl
-
93% inhibition at 10 mM
2,2'-dipyridyl
-
57% inhibition at 1 mM
2-mercaptoethanol
-
-
2-mercaptoethanol
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26% inhibition at 1 mM
2-mercaptoethanol
-
78% inhibition at 1 mM
2-mercaptoethanol
-
81% inhibition at 1150 mM
Cd2+
-
potent inhibitor
Cd2+
-
moderate inhibitor
Co2+
-
20% inhibition at 0.01 mM
concanavalin A
-
-
-
concanavalin A
-
91% inhibition at 50 micromol/ml
-
concanavalin A
-
potent inhibitor
-
concanavalin A
-
74% inhibition at 50 micromol/ml
-
Cu2+
-
-
Cu2+
-
60% inhibition at 0.01 mM
Cu2+
-
63% inhibition at 0.1 mM
dithiothreitol
-
88% inhibition at 1 mM
dithiothreitol
-
77% inhibition at 0.5 mM
EDTA
-
-
EDTA
-
100% inhibition at 7.5 mM
EDTA
-
100% inhibition at 7.5 mM
EDTA
-
100% inhibition at 10 mM
EDTA
-
100% inhibition at 2.5 mM
Fetal bovine serum
-
-
-
Fetal bovine serum
-
34% inhibition at concentration of 2%
-
Fetal bovine serum
-
56% inhibition at concentration of 2%
-
heparan sulfate
-
-
heparan sulfate
-
38% inhibition at 0.5 micromol/ml
heparan sulfate
-
potent inhibitor
heparan sulfate
-
50% inhibition at 0.05 micromol/ml
heparin
-
76% inhibition at 0.05 micromol/ml
heparin
-
52-58% inhibition at 0.05 micromol/ml
heparin
-
potent inhibitor
heparin
-
76% inhibition at 0.05 micromol/ml
Mg2+
-
-
Mg2+
-
64% inhibition at 5 mM
Mn2+
-
-
Mn2+
-
49% inhibition at 5 mM
Ni2+
-
-
Ni2+
-
19% inhibition at 0.01 mM
Ni2+
-
42% inhibition at 0.1 mM
papilin
-
-
phosphate
-
-
phosphate
-
,46% inhibition at 2 mM
phosphate
-
100% inhibition at 10 mM sodium phosphate
Poly-L-aspartate
-
-
Poly-L-aspartate
-
24% inhibition at 50 micromol/ml
Poly-L-aspartate
-
81% inhibition at 10 micromol/ml
Poly-L-glutamate
-
-
Poly-L-glutamate
-
40% inhibition at 50 micromol/ml
Poly-L-glutamate
-
89% inhibition at 10 micromol/ml
SDS
-
-
SDS
-
79% inhibition at 50 micromol/ml
SDS
-
84% inhibition at 50 micromol/ml
TIMP3
-
-
Zn2+
-
-
Zn2+
-
73% inhibition at 0.01 mM
Zn2+
-
92% inhibition at 0.1 mM
additional information
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not inhibited by serine protease inhibitors, lysine or serum
-
additional information
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not inhibited by serine proteinase inhibitor
-
additional information
no inhibition by AEBSF, NEM and PMSF
-
additional information
-
not inhibited by TIMP-1, TIMP-2 and TIMP-4
-
additional information
no inhibition by AEBSF, NEM and PMSF
-
additional information
-
no inhibition by AEBSF, NEM and PMSF
-
3.4.24.14 procollagen N-endopeptidase
results (
results (
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