3.4.24.1: atrolysin A

This is an abbreviated version!
For detailed information about atrolysin A, go to the full flat file.

Word Map on EC 3.4.24.1

3.4.24.1

thrombospondin

metalloproteinases

integrins

adamts

collagen

platelet

endothelial

cartilage

thrombotic

ectodomains

willebrand

aggrecan

chondrocytes

thrombocytopenic

purpura

osteoarthritis

articular

rgd

ttp

cysteine-rich

proteoglycans

sheddase

membrane-anchored

viper

alphavbeta3

alpha-secretase

aggrecanase

timp-3

arg-gly-asp

microangiopathic

adamts-13

trimeresurus

rgd-containing

svmps

hb-egf

envenom

echis

carinatus

versican

metzincins

metalloproteinase-13

schistocytes

prodomains

sperm-egg

medicine

bothrops

viperidae

agkistrodon

alphaiibbeta3

rattlesnake

non-amyloidogenic

Reaction

Cleavage of Asn3-/-Gln, His5-/-Leu, His10-/-Leu, Ala14-/-Leu and Tyr16-/-Leu in insulin B chain; removes C-terminal Leu from small peptides =

Synonyms

atrolysin-e, Cam-dis, CAMP, CatroxMP-II, CaVMP-II, crotalus atrox alpha-proteinase, crotalus atrox metalloproteinase, crotalus atrox proteinase, crotalus atrox.alpha.-proteinase, Crotatroxin, disintegrin, fibrinogenolytic metalloproteinase, hemorrhagic toxin a, proteinase, Crotalus atrox, snake venom disintegrin, snake venom metalloprotease, snake venom metalloproteinase, SVMP, zinc metalloproteinase-disintegrin VMP-II

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.24 Metalloendopeptidases

3.4.24.1 atrolysin A

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Results	in table
8	AA Sequence
2	Application
1	CAS Registry Number
3	Cloned(Commentary)
1	Crystallization (Commentary)
6	General Information
25	Inhibitors
1	KM Value [mM]
3	Localization
13	Metals/Ions
19	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
23	Organism
3	pH Optimum
2	pH Range
4	pI Value
4	Posttranslational Modification
7	Purification (Commentary)
1	Reaction
2	Reaction Type
23	Reference
15	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
48	Substrates and Products (Substrate)
16	Subunits
21	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
1	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.4.24.1 - atrolysin A

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alpha fibrinogen + H2O

2 entries

alpha1-Antichymotrypsin + H2O

Crotalus atrox

36962

alpha2-macroglobulin + H2O

angiotensin I + H2O

beta fibrinogen + H2O

2 entries

casein + H2O

Crotalus atrox

preferential cleavage: -Leu, -Ile, -Val, -Phe

Collagen + H2O

demethylcasein + H2O

fibrinogen + H2O

fibrin + ?

Fibronectin + H2O

Gelatin + H2O

31268, 36963, 36964

insulin B chain + H2O

2 entries

Laminin + H2O

Crotalus atrox

36963

Leu-Val-Glu-Ala-Leu-Tyr-Leu + H2O

Crotalus atrox

31265

Nalpha-benzoyl-L-arginine-7-amido-4-methylcoumarin + H2O

Nalpha-benzoyl-L-arginine + 7-amino-4-methylcoumarin

Nidogen + H2O

Proteins + H2O

Type I collagen + H2O

Crotalus atrox

enzyme binds via exosites in the cysteine-rich domain

667515

Type IV collagen + H2O

Crotalus atrox

31268, 36963, 36964

von Willebrand factor + H2O

Crotalus atrox

enzyme binds via exosites in the cysteine-rich domain

667515

additional information

8 entries