3.4.23.B5: murine leukemia virus protease

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For detailed information about murine leukemia virus protease, go to the full flat file.

Reaction

processing of viral polyprotein. The retroviral protease is essential for virus replication, by processing of viral Gag and Gag-Pol polyproteins =

Synonyms

MLV PR, MLV protease, MLV retropepsin, MMLV protease, Mo-MuLV PR, Mo-MuLV protease, Moloney MLV retropepsin, Moloney murine leukemia virus protease, Moloney murine leukemia virus retropepsin, More, MuLV 4070A, MuLV proteinase, murine leukemia virus protease, viral protease, vPR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B5 murine leukemia virus protease

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Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
2	Crystallization (Commentary)
2	IC50 Value
19	Inhibitors
1	kcat/KM [mM/s]
12	Ki Value [mM]
94	KM Value [mM]
2	Metals/Ions
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
20	Organism
5	pH Optimum
1	pH Range
1	Posttranslational Modification
24	Protein Variants
5	Purification (Commentary)
3	Reaction
1	Reaction Type
20	Reference
2	Specific Activity [micromol/min/mg]
166	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
4	Temperature Optimum [°C]
96	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.23.B5 - murine leukemia virus protease

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MOLECULAR WEIGHT

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

13315

Moloney murine leukemia virus

-

2 * 13315, sequence calculation, homodimer, structure molecular modeling

668798

14000

Xenotropic MuLV-related virus VP62

A1Z651

x * 17000 and x * 14000, SDS-PAGE, corresponding to the expected mobility of the full-length protease and the truncated form by auto-cleavage of the flanking 20 amino acids at both ends

734565

14100

murine leukemia virus

-

purified recombinant enzyme, MALDI-TOF mass spectrometry

670761

17000

Xenotropic MuLV-related virus VP62

A1Z651

x * 17000 and x * 14000, SDS-PAGE, corresponding to the expected mobility of the full-length protease and the truncated form by auto-cleavage of the flanking 20 amino acids at both ends

734565