3.4.23.B5: murine leukemia virus protease

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For detailed information about murine leukemia virus protease, go to the full flat file.

Reaction

processing of viral polyprotein. The retroviral protease is essential for virus replication, by processing of viral Gag and Gag-Pol polyproteins =

Synonyms

MLV PR, MLV protease, MLV retropepsin, MMLV protease, Mo-MuLV PR, Mo-MuLV protease, Moloney MLV retropepsin, Moloney murine leukemia virus protease, Moloney murine leukemia virus retropepsin, More, MuLV 4070A, MuLV proteinase, murine leukemia virus protease, viral protease, vPR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B5 murine leukemia virus protease

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Results	in table
2	AA Sequence
1	Application
1	CAS Registry Number
9	Cloned(Commentary)
2	Crystallization (Commentary)
2	IC50 Value
19	Inhibitors
1	kcat/KM [mM/s]
12	Ki Value [mM]
94	KM Value [mM]
2	Metals/Ions
4	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
20	Organism
5	pH Optimum
1	pH Range
1	Posttranslational Modification
24	Protein Variants
5	Purification (Commentary)
3	Reaction
1	Reaction Type
20	Reference
2	Specific Activity [micromol/min/mg]
166	Substrates and Products (Substrate)
3	Subunits
19	Synonyms
4	Temperature Optimum [°C]
96	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.23.B5 - murine leukemia virus protease

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000002 - 0.00001

amprenavir

2 entries

0.0000018 - 0.000022

atazanavir

2 entries

0.00000014

DMP323

Moloney murine leukemia virus

-

pH 5.6, 37°C, recombinant enzyme

669690

0.00000021

indinavir

Moloney murine leukemia virus

-

pH 5.6, 37°C, recombinant enzyme

669690

0.0000019

KH-164

Moloney murine leukemia virus

-

pH 5.6, 37°C, recombinant enzyme

669690

0.000002

nelfinavir

Moloney murine leukemia virus

-

pH 5.6, 37°C, recombinant enzyme

669690

0.00144

pepstatin A

Xenotropic MuLV-related virus

-

substrate RSLLYPALTP, pH 5.6, 37°C

717598

0.00000041

ritonavir

Moloney murine leukemia virus

-

pH 5.6, 37°C, recombinant enzyme

669690

0.000028

saquinavir

Moloney murine leukemia virus

-

pH 5.6, 37°C, recombinant enzyme

669690

0.000102

TL-3

Xenotropic MuLV-related virus

-

substrate RSLLYPALTP, pH 5.6, 37°C

717598

0.0000002

amprenavir

Xenotropic MuLV-related virus

-

substrate RSLLYPALTP, pH 5.6, 37°C

717598

0.00001

amprenavir

Xenotropic MuLV-related virus

-

substrate KARVnLNphEAnLG, pH 5.6, 25°C

717598

0.0000018

atazanavir

Xenotropic MuLV-related virus

-

substrate RSLLYPALTP, pH 5.6, 37°C

717598

0.000022

atazanavir

Xenotropic MuLV-related virus

-

substrate KARVnLNphEAnLG, pH 5.6, 25°C

717598