3.4.23.B18: mouse mammary tumor virus retropepsin

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For detailed information about mouse mammary tumor virus retropepsin, go to the full flat file.

Reaction

Processing of viral polyprotein. Selective for large aromatic residues (Tyr and Phe) at position P1. Phe and Leu are preferred at position P3. No hydrolysis of substrates with Gly or Ala at position P3. Medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4. =

Synonyms

MMTV PR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B18 mouse mammary tumor virus retropepsin

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Results	in table
2	Organism
1	Reaction
2	Reference
10	Substrates and Products (Substrate)
2	Synonyms

Substrates Products

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Substrates Products on EC 3.4.23.B18 - mouse mammary tumor virus retropepsin

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

VFQNYPIVQ + H2O

VFQNY + PIVQ

mouse mammary tumor virus

-

medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4

693905

-

-

?

VIQNYPIVQ + H2O

VIQNY + PIVQ

mouse mammary tumor virus

-

medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4

693905

-

-

?

VLQNYPIVQ + H2O

VLQNY + PIVQ

mouse mammary tumor virus

-

medium-sized or large hydrophobic residues as Ile, Leu and Phe are preferred at position P4

693905

-

-

?

VSFNYPIVQ + H2O

VSFNY + PIVQ

mouse mammary tumor virus

-

Phe and Leu are preferred at position P3. No hydrolysis of substrates with Gly or Ala at position P3

693905

-

-

?

VSLNYPIVQ + H2O

VSLNY + PIVQ

mouse mammary tumor virus

-

Phe and Leu are preferred at position P3. No hydrolysis of substrates with Gly or Ala at position P3

693905

-

-

?

VSQCYPIVG + H2O

VSQCY + PIVG

mouse mammary tumor virus

-

peptides with an Ile at position P2 are the best substrate, lower activity with Cys or Leu at position P2

666190

-

-

?

VSQIYPIVG + H2O

VSQIY + PIVG

mouse mammary tumor virus

-

peptides with an Ile at position P2 are the best substrate, lower activity with Cys or Leu at position P2

666190

-

-

?

VSQLYPIVG + H2O

VSQLY + PIVG

mouse mammary tumor virus

-

peptides with an Ile at position P2 are the best substrate, lower activity with Cys or Leu at position P2

666190

-

-

?

VSQNFPIVQ + H2O

VSQNF + PIVQ

mouse mammary tumor virus

-

selective for large aromatic residues (Tyr and Phe) at position P1

693905

-

-

?

VSQNYPIVQ + H2O

VSQNY + PIVQ

mouse mammary tumor virus

-

selective for large aromatic residues (Tyr and Phe) at position P1

693905

-

-

?