3.4.23.B13: proteinase P15
This is an abbreviated version!
For detailed information about proteinase P15, go to the full flat file.
Word Map on EC 3.4.23.B13
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3.4.23.B13
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inflammasome
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caspase-1
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lipopolysaccharide
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pyroptosis
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noncanonical
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casp11
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caspase-11-dependent
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nod-like
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wedelolactone
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guanylate-binding
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endotoxic
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caspase-11-deficient
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gsdmd
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legionella
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rodentium
- 3.4.23.B13
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inflammasome
- caspase-1
- lipopolysaccharide
-
pyroptosis
-
noncanonical
-
casp11
-
caspase-11-dependent
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nod-like
- wedelolactone
-
guanylate-binding
-
endotoxic
-
caspase-11-deficient
-
gsdmd
-
legionella
-
rodentium
Reaction
efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor =
Synonyms
15gag proteinase, MAV-PR, myeloblastosis associated virus proteinase, p15gag proteinase
ECTree
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Substrates Products
Substrates Products on EC 3.4.23.B13 - proteinase P15
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REACTION DIAGRAM
Ala-Ser-Ala-Pro-Pro-Pro-Pro-Tyr-Val-Gly-Ser-Gly-Leu-Tyr-Pro-Ser + H2O
Ala-Ser-Ala-Pro-Pro-Pro-Pro-Tyr-Val-Gly + Ser-Gly-Leu-Tyr-Pro-Ser
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50%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Leu + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Met-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Met + Phe(NO2)-Val-Arg-Lys-Ala
75.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Met-Pro-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Met + Pro-Val-Arg-Lys-Ala
52% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Val-Ser-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Ser + Phe(NO2)-Val-Arg-Lys-Ala
9.4% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Gln-His-Thr + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Gln-His-Thr
54.2% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Met-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Met-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
71.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg
6% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu
14% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala + H2O
Ala-Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala
6.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Tyr-Phe(NO2)-Ala-Gln-Phe-Thr + H2O
Ala-Thr-Phe-Gln-Ala-Tyr + Phe(NO2)-Ala-Gln-Phe-Thr
12.9% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Ala-Gln-Phe-Thr + H2O
Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Ala-Gln-Phe-Thr
88.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Cys-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
Cys-Glu-Val-Thr-Gly-Val-Arg-Ala-Asp-Val-His-Leu-Leu-Glu-Gln-Pro + H2O
Cys-Glu-Val-Thr-Gly-Val-Arg-Ala + Asp-Val-His-Leu-Leu-Glu-Gln-Pro
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35% of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Gly-Pro-Glu-Pro-Pro-Ala-Val-Ser-Leu-Ala-Met-Thr-Met-Glu-His-Lys + H2O
Gly-Pro-Glu-Pro-Pro-Ala-Val-Ser + Leu-Ala-Met-Thr-Met-Glu-His-Lys
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80%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro + H2O
Gly-Pro-Val-Val-Phe(NO2) + Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
HIV-1 polyprotein + H2O
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cleavage of the HIV-1 polyprotein only at concentrations above 0.001 mM. Cleavage products are very similar or identical to that of HIV-1 protease
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?
Leu-Glu-Lys-Ser-His-Cys-Ile-Ala-Glu-Val-Glu-Lys-Asp-Ala-Ile-Pro + H2O
Leu-Glu-Lys-Ser-His-Cys-Ile-Ala + Glu-Val-Glu-Lys-Asp-Ala-Ile-Pro
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50%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
20% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu + H2O
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu
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90%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu-Lys + H2O
Ser-Gln-Ala-Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala-Val-Ile-Leu-Lys
6% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Thr-Gly-Pro-Pro-Val-Val-Ala-Met-Pro-Val-val-Ile-Lys-Thr-Glu-Gly + H2O
Thr-Gly-Pro-Pro-Val-Val-Ala-Met + Pro-Val-Val-Ile-Lys-Thr-Glu-Gly
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10%of the activity with Gly-Pro-Val-Val-Phe(NO2)-Ser-Val-Ser-Thr-Lys-Glu-Leu-Pro
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?
Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
Thr-Phe-Gln-Ala-Tyr-Pro-Leu-Arg-Glu-Ala + H2O
Thr-Phe-Gln-Ala-Tyr + Pro-Leu-Arg-Glu-Ala
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?
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Arg-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
53.7% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asn-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
30.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Asp-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
32.2% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ala-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
12.1% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Ile-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
36.3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Leu-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
2.5% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
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Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Phe + Phe(NO2)-Val-Arg-Lys-Ala
48.1% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Glu-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
50% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Tyr-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
45% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-His-Val-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
3% of the activity with Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala + H2O
Ala-Thr-Pro-Gln-Val-Tyr + Phe(NO2)-Val-Arg-Lys-Ala
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?
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
33% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
Thr-Phe-Gln-Ala-Phe(NO2)-Pro-Leu-Arg-Glu-Ala-Val + H2O
Thr-Phe-Gln-Ala-Phe(NO2) + Pro-Leu-Arg-Glu-Ala-Val
42% of the activity with Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?
?
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the enzyme prefers hydrophobic residues with bulky side chains (Met, Tyr, Phe) in P3, although Arg and Gln can also be accepted. Small hydrophobic residues are required in P2 and P2', and large hydrophobic residues (Tyr, Met, Phe, Phe(NO2)) are preferred in both P1 and P1'
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additional information
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hydrophobic or aromatic residues are preferable in P1 position, a broad variety of residues are acceptable in P3, the residues occupying P2 plays the decisive role in substrate cleavage, Glu is the preferred amino acid at this position. No cleavage: Ala-Thr-His-Gln-Val-Ser-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Val-Arg-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Val-Glu-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Gly-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, Ala-Thr-His-Gln-Phe-Tyr-Phe(NO2)-Val-Arg-Lys-Ala , Ala-Thr-His-Pro-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
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?