3.4.23.B13: proteinase P15

This is an abbreviated version!
For detailed information about proteinase P15, go to the full flat file.

Word Map on EC 3.4.23.B13

3.4.23.B13

inflammasome

caspase-1

lipopolysaccharide

pyroptosis

noncanonical

casp11

caspase-11-dependent

nod-like

wedelolactone

guanylate-binding

endotoxic

caspase-11-deficient

gsdmd

legionella

rodentium

Reaction

efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor =

Synonyms

15gag proteinase, MAV-PR, myeloblastosis associated virus proteinase, p15gag proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.B13 proteinase P15

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Results	in table
1	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
18	IC50 Value
57	Inhibitors
43	Ki Value [mM]
47	KM Value [mM]
2	Localization
1	Metals/Ions
2	Molecular Weight [Da]
10	Organism
4	pH Optimum
1	pI Value
4	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
10	Reference
1	Specific Activity [micromol/min/mg]
72	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
49	Turnover Number [1/s]

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Reference on EC 3.4.23.B13 - proteinase P15

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647790

Konvalinka, J.; Blaha, I.; Skrabana, R.; Sedlacek, J.; Pichova, I.; Kapralek, F.; Kostka, V.; Strop, P.

Subsite specificity of the proteinase from myeloblastosis associated virus

FEBS Lett.

282

73-76

1991

Avian myeloblastosis-associated virus (P26315)

2026269

647791

Ohlendorf, D.H.; Foundling, S.I.; Wendoloski, J.J.; Sedlacek, J.; Strop, P.; Salemme, F.R.

Structural studies of the retroviral proteinase from avian myeloblastosis associated virus

Proteins

382-391

1992

Avian myeloblastosis-associated virus (P26315)

1332025

647792

Pavlickova, L.; Stys, D.; Soucek, M.; Urban, J.; Hruskova, O.; Sedlacek, J.; Strop, P.

15gag proteinase of myeloblastosis-associated virus: specificity studies with substrate-based inhibitors

Arch. Biochem. Biophys.

298

753-756

1992

Avian myeloblastosis-associated virus

1417001

647793

Sedlacek, J.; Fabry, M.; Coward, J.E.; Horejsi, M.; Strop, P.; Luftig, R.B.

Myeloblastosis associated virus (MAV) proteinase site-mutated to be HIV-like has a higher activity and allows production of infectious but morphologically altered virus

Virology

192

667-672

1993

Avian myeloblastosis-associated virus

7678476

647794

Strop, P.; Konvalinka, J.; Stys, D.; Pavlickova, L.; Blaha, I.; Velek, J.; Travnicek, M.; Kostka, V.; Sedlacek, J.

Specificity studies on retroviral proteinase from myeloblastosis-associated virus

Biochemistry

3437-3443

1991

Avian myeloblastosis-associated virus (P26315)

1849425

647795

Pichova, I.; Strop, P.; Sedlacek, J.; Kapralek, F.; Benes, V.; Travnicek, M.; Pavlickova, L.; Soucek, M.; Kostka, V.; Foundling, S.

Isolation, biochemical characterization and crystallization of the p15gag proteinase of myeloblastosis associated virus expressed in E. coli

Int. J. Biochem.

235-242

1992

Avian myeloblastosis-associated virus (P26315), Avian myeloblastosis-associated virus

1733789

647796

Konvalinka, J.; Horejsi, M.; Andreansky, M.; Novek, P.; Pichova, I.; Blaha, I.; Fabry, M.; Sedlacek, J.; Foundling, S.; Strop, P.

An engineered retroviral proteinase from myeloblastosis associated virus acquires pH dependence and substrate specificity of the HIV-1 proteinase

EMBO J.

1141-1144

1992

Avian myeloblastosis-associated virus

1547777

647797

Strop, P.; Horejsi, M.; Konvalinka, J.; Skrabana, R.; Velek, J.; Blaha, I.; Cerna, V.; Pichova, I.; Pavlickova, L.; et al.

Protein-engineered proteinase of myeloblastosis associated virus, an enzyme of high activity and HIV-1 proteinase-like specificity

Adv. Exp. Med. Biol.

306

515-518

1991

Avian myeloblastosis-associated virus

1812751

647798

Strop, P.; Pavlickova, L.; Stys, D.; Soucek, M.; Urban, J.; Hruskova, O.; Kapralek, F.; Jecmen, P.; Sedlacek, J.; Kostka, V.

p15gag proteinase of myeloblastosis associated virus: specificity studies with substrate based inhibitors

Adv. Exp. Med. Biol.

306

519-523

1991

Avian myeloblastosis-associated virus

1812752

647799

Konvalinka, J.; Heuser, A.M.; Hruskova-Heidingsfeldova, O.; Vogt, V.M.; Sedlacek, J.; Strop, P.; Krausslich, H.G.

Proteolytic processing of particle-associated retroviral polyproteins by homologous and heterologous viral proteinases

Eur. J. Biochem.

228

191-198

1995

Avian myeloblastosis-associated virus

7883003