3.4.23.B13: proteinase P15
This is an abbreviated version!
For detailed information about proteinase P15, go to the full flat file.
Word Map on EC 3.4.23.B13
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3.4.23.B13
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inflammasome
-
caspase-1
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lipopolysaccharide
-
pyroptosis
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noncanonical
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casp11
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caspase-11-dependent
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nod-like
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wedelolactone
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guanylate-binding
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endotoxic
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caspase-11-deficient
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gsdmd
-
legionella
-
rodentium
- 3.4.23.B13
-
inflammasome
- caspase-1
- lipopolysaccharide
-
pyroptosis
-
noncanonical
-
casp11
-
caspase-11-dependent
-
nod-like
- wedelolactone
-
guanylate-binding
-
endotoxic
-
caspase-11-deficient
-
gsdmd
-
legionella
-
rodentium
Reaction
efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor =
Synonyms
15gag proteinase, MAV-PR, myeloblastosis associated virus proteinase, p15gag proteinase
ECTree
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KM Value
KM Value on EC 3.4.23.B13 - proteinase P15
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0.017
Ala-Thr-His-Asn-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.052
Ala-Thr-His-Gln-Val-Leu-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.014
Ala-Thr-His-Val-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.008
Ala-Thr-Pro-Cys-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.009
Ala-Thr-Pro-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.004
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.024
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.024
Ala-Thr-His-Arg-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.025
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.025
Ala-Thr-His-Asp-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.009
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.009
Ala-Thr-His-Gln-Ala-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.042
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.042
Ala-Thr-His-Gln-Ile-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.025
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.12
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.12
Ala-Thr-His-Gln-Leu-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.013
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.031
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.031
Ala-Thr-His-Gln-Val-Phe-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.007
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.075
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.082
Ala-Thr-His-Gln-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.003
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.0033
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.006
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.006
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C
0.0062
Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.0016
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.002
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
mutant enzyme A100L/V104T/R105P/G106V/S107N
0.026
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
-
wild-type enzyme
0.026
Ala-Thr-His-Tyr-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala
pH 6.0, 37°C