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3.4.23.B13: proteinase P15

This is an abbreviated version!
For detailed information about proteinase P15, go to the full flat file.

Word Map on EC 3.4.23.B13

Reaction

efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor =

Synonyms

15gag proteinase, MAV-PR, myeloblastosis associated virus proteinase, p15gag proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B13 proteinase P15

KI Value

KI Value on EC 3.4.23.B13 - proteinase P15

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00013
Ala-Thr-His-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-His-Thr-Ala
-
pH 6.0, 37°C
0.00016
Ala-Thr-His-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Lys-Ala
-
pH 6.0, 37°C
0.000172
Arg-Arg-Arg-Met-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.0059
Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.0026
Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Met-Pro
-
pH 6.0, 37°C
0.00028
butyloxycarbonyl-Tyr-Val-statine-Ala-statine methyl ester
-
pH 6.0, 37°C
0.00518
Cys-Thr-Asn-Leu-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ile-Ser-Pro-Ile
-
-
0.00436
Cys-Thr-Asn-Leu-PhePSI[CH2NH]-Pro-Ile-Ser-Pro-Ile
-
pH 6.0, 37°C
0.00024
Gly-Pro-Val-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Ser-Thr-Ala
-
pH 6.0, 37°C
0.016
His-Pro-His-Leu-Ser-PhePSI[CH2NH]-Met-Ala-Tyr
-
pH 6.0, 37°C
0.09
His-Ser-Leu-Arg-PhePSI[CH2NH]Phe-Arg-Leu-Pro
-
pH 6.0, 37°C
0.02
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
-
pH 6.0, 37°C
0.00003
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
-
pH 6, 37°C
0.0011
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00004
Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00039
Pro-Cys-Val--((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00016
Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
-
pH 6.0, 37°C
0.00025
Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
-
pH 6, 37°C
0.0052
Pro-Pro-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Gln-Pro-Pro
-
pH 6.0, 37°C
0.00312
Pro-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro-Pro
-
pH 6.0, 37°C
0.0002
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
0.000005 - 0.00001
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
0.019
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Gly-Leu-Tyr-Pro
-
pH 6.0, 37°C
0.00095
Pro-Pro-Tyr-Val-statine-Gly-Leu-Tyr-Pro
-
pH 6.0, 37°C
0.00001
Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
-
pH 6.0, 37°C
0.000065
Pro-Thr-Phe-Gln-Ala-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Leu-Arg-Glu-Ala-Pro
-
pH 6, 37°C
0.00043
Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Arg-Pro
-
pH 6.0, 37°C
0.00157
Thr-Phe-(S-methylcysteine)-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.00032
Thr-Phe-Cys-Ala-[(3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid]-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.00013
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
pH 6.0, 37°C
0.00087
Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
-
pH 6, 37°C
0.0158
Thr-Phe-Gln-Ala-PhePSI[CH2-NH]Pro-Leu-Arg-Glu-Ala
-
pH 6.0, 37°C
0.000026
Thr-Thr-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
-
pH 6.0, 37°C
additional information
additional information
-
Ki-value for Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met is below 0.01 mM. The Ki-value for Pro-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-Phe-Pro, Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Arg-Pro and Pro-Cys-Val-((3S,4S)-4-amino-7-guanidino-3-hydroxyheptanoic acid)-Val-Arg-Pro are above 0.1 mM: The Ki-value for Met-Ser-Leu-Asn-statine-Val-Ala-Lys-Val is above 0.08 mM
-