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3.4.23.B13: proteinase P15

This is an abbreviated version!
For detailed information about proteinase P15, go to the full flat file.

Word Map on EC 3.4.23.B13

Reaction

efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor =

Synonyms

15gag proteinase, MAV-PR, myeloblastosis associated virus proteinase, p15gag proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.B13 proteinase P15

Inhibitors

Inhibitors on EC 3.4.23.B13 - proteinase P15

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ala-Thr-His-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-His-Thr-Ala
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Ala-Thr-His-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Lys-Ala
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Arg-Arg-Arg-Met-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Met-Pro
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Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Met-Pro
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Arg-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Met-Pro
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butyloxycarbonyl-Tyr-Val-statine-Ala-statine methyl ester
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Cys-Thr-Asn-Leu-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ile-Ser-Pro-Ile
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Cys-Thr-Asn-Leu-PhePSI[CH2NH]-Pro-Ile-Ser-Pro-Ile
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Gly-Pro-Val-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Ser-Thr-Ala
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His-Pro-His-Leu-Ser-PhePSI[CH2NH]-Met-Ala-Tyr
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His-Ser-Leu-Arg-PhePSI[CH2NH]Phe-Arg-Leu-Pro
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Met-Ser-Leu-Asn-statine-Val-Ala-Lys-Val
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Pro-Ala-Val-statine-Ala-Met-Thr-Met
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IC50 above 1.5 mM, Ki-value above 0.16 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-mercaptopentanoic acid)-Val-Arg-Pro
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Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro
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IC50 is above 0.06 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr
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IC50: 0.04 mM
Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
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Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-6-methylthiohexanoic acid)-Val-Arg-Pro
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Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro
Pro-Cys-Val-((3S,4S)-4-amino-7-guanidino-3-hydroxyheptanoic acid)-Val-Arg-Pro
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Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Arg-Pro
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Pro-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Gln-Phe-Pro
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Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.037 mM
Pro-Pro-Ala-Val-D-Ser-Leu-Ala-Met-Thr-Met
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IC50: above 1.5 mM, Ki-value: above 0.05 mM
Pro-Pro-Ala-Val-Ser-D-Leu-Ala-Met-Thr-Met
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IC50: above 1.5 mM, Ki-value: above 0.06 mM
Pro-Pro-Ala-Val-statine-Ala-Met-Thr-Met
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IC50: above 1.5 mM, Ki-value: above 0.1 mM
Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.009 mM
Pro-Pro-Gln-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Val-Gln-Pro-Pro
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Pro-Pro-Met-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro-Pro
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Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.0125 mM
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
Pro-Pro-Tyr-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Gly-Leu-Tyr-Pro
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Pro-Pro-Tyr-Val-statine-Gly-Leu-Tyr-Pro
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Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met
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IC50: 0.003 mM
Pro-Thr-Phe-Gln-Ala-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Leu-Arg-Glu-Ala-Pro
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Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Arg-Pro
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Thr-Phe-Cys-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
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Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
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Thr-Phe-Gln-Ala-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Leu-Arg-Glu-Ala
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Thr-Phe-Gln-Ala-PhePSI[CH2-NH]Pro-Leu-Arg-Glu-Ala
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Thr-Phe-Gln-Ala-Phe[CH2-NH]Pro-Leu-Arg-Glu-Ala
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IC50: 1.1 mM
Thr-Phe-[(S-methylcysteine)-Ala-(3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid]-Leu-Arg-Glu-Ala
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Thr-Thr-Phe-Gln-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Gln-Phe-Thr
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