3.4.23.B13: proteinase P15

This is an abbreviated version!
For detailed information about proteinase P15, go to the full flat file.

Reaction

efficient cleavage of Ala-Thr-His-Glu-Val-Tyr-Phe(NO2)-Val-Arg-Lys-Ala, no cleavage with Ser, Arg or Glu at P1, Gly or Phe at P2, and Pro at P3. Specifically liberates the five major structural proteins from the common gag precursor, as well as reverse transcriptase and integrase from the gag-pol precursor =

Synonyms

15gag proteinase, MAV-PR, myeloblastosis associated virus proteinase, p15gag proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B13 proteinase P15

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Results	in table
1	AA Sequence
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
18	IC50 Value
57	Inhibitors
43	Ki Value [mM]
47	KM Value [mM]
2	Localization
1	Metals/Ions
2	Molecular Weight [Da]
10	Organism
4	pH Optimum
1	pI Value
4	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reaction Type
10	Reference
1	Specific Activity [micromol/min/mg]
72	Substrates and Products (Substrate)
1	Subunits
4	Synonyms
49	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.23.B13 - proteinase P15

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1.5

Pro-Ala-Val-statine-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50 above 1.5 mM, Ki-value above 0.16 mM

647792

0.06

Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Pro

Avian myeloblastosis-associated virus

-

IC50 is above 0.06 mM

647792

0.04

Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr

Avian myeloblastosis-associated virus

-

IC50: 0.04 mM

647792, 647798

0.06

Pro-Cys-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Val-Arg-Pro

Avian myeloblastosis-associated virus

-

IC50: 0.06 mM

647798

0.037

Pro-Pro-Ala-Val-((3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid)-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: 0.037 mM

647792, 647798

1.5

Pro-Pro-Ala-Val-D-Ser-Leu-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: above 1.5 mM, Ki-value: above 0.05 mM

647792

1.5

Pro-Pro-Ala-Val-Ser-D-Leu-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: above 1.5 mM, Ki-value: above 0.06 mM

647792

1.5

Pro-Pro-Ala-Val-statine-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: above 1.5 mM, Ki-value: above 0.1 mM

647792

0.009

Pro-Pro-Cys-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: 0.009 mM

647792, 647798

0.0125

Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-(4-nitrophenyl)pentanoic acid)-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: 0.0125 mM

647792, 647798

0.0125

Pro-Pro-Tyr-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: 0.0125 mM

647792

0.003

Pro-Pro-Val-((3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid)-Ala-Met-Thr-Met

Avian myeloblastosis-associated virus

-

IC50: 0.003 mM

647792, 647798

1.1

Thr-Phe-Gln-Ala-Phe[CH2-NH]Pro-Leu-Arg-Glu-Ala

Avian myeloblastosis-associated virus

-

IC50: 1.1 mM

647798