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3.4.23.48: plasminogen activator Pla

This is an abbreviated version!
For detailed information about plasminogen activator Pla, go to the full flat file.

Word Map on EC 3.4.23.48

Reaction

Converts human Glu-plasminogen to plasmin by cleaving the Arg560-/-Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins =

Synonyms

beta-Pla, coagulase, fibrinolysin, outer membrane protease, Pla, Pla protease, plasminogen activator, plasminogen activator Pla, plasminogen activator protease Pla, YapE

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.48 plasminogen activator Pla

Reference

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Reference on EC 3.4.23.48 - plasminogen activator Pla

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kienle, Z.; Emody, L.; Svanborg, C.; O'Toole, P.W.
Adhesive properties conferred by the plasminogen activator of Yersinia pestis
J. Gen. Microbiol.
138
1679-1687
1992
Yersinia pestis
-
Manually annotated by BRENDA team
Lahteenmaki, K.; Virkola, R.; Saren, A.; Emody, L.; Korhonen, T.K.
Expression of plasminogen activator Pla of Yersinia pestis enhances bacterial attachment to the mammalian extracellular matrix
Infect. Immun.
66
5755-5762
1998
Yersinia pestis
Manually annotated by BRENDA team
Kutyrev, V.; Mehigh, R.J.; Motin, V.L.; Pokrovskaya, M.S.; Smirnov, G.B.; Brubaker, R.R.
Expression of the plague plasminogen activator in Yersinia pseudotuberculosis and Escherichia coli
Infect. Immun.
67
1359-1367
1999
Yersinia pestis
Manually annotated by BRENDA team
Lahteenmaki, K.; Kukkonen, M.; Korhonen, T.K.
The Pla surface protease/adhesin of Yersinia pestis mediates bacterial invasion into human endothelial cells
FEBS Lett.
504
69-72
2001
Yersinia pestis
Manually annotated by BRENDA team
Kukkonen, M.; Lahteenmaki, K.; Suomalainen, M.; Kalkkinen, N.; Emody, L.; Lang, H.; Korhonen, T.K.
Protein regions important for plasminogen activation and inactivation of a2-antiplasmin in the surface protease Pla of Yersinia pestis
Mol. Microbiol.
40
1097-1111
2001
Yersinia pestis
Manually annotated by BRENDA team
Lahteenmaki, K.; Kuusela, P.; Korhonen, T.K.
Bacterial plasminogen activators and receptors
FEMS Microbiol. Rev.
25
531-552
2001
Mammalia, Mycobacterium tuberculosis, Streptococcus uberis, Yersinia pestis
Manually annotated by BRENDA team
Benedek, O.; Bene, J.; Melegh, B.; Emody, L.
Mapping of possible laminin binding sites of Y. pestis plasminogen activator (Pla) via phage display
Adv. Exp. Med. Biol.
529
101-104
2003
Yersinia pestis
Manually annotated by BRENDA team
Lobo, L.A.
Adhesive properties of the purified plasminogen activator Pla of Yersinia pestis
FEMS Microbiol. Lett.
262
158-162
2006
Yersinia pestis
Manually annotated by BRENDA team
Korhonen, T.K.; Lahteenmaki, K.; Kukkonen, M.; Lang, H.
Plasminogen activator of Yersinia pestis
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
1
217-219
2004
Yersinia pestis
-
Manually annotated by BRENDA team
Benedek, O.; Khan, A.S.; Schneider, G.; Nagy, G.; Autar, R.; Pieters, R.J.; Emody, L.
Identification of laminin-binding motifs of Yersinia pestis plasminogen activator by phage display
Int. J. Med. Microbiol.
295
87-98
2005
Yersinia pestis
Manually annotated by BRENDA team
Chromy, B.A.; Choi, M.W.; Murphy, G.A.; Gonzales, A.D.; Corzett, C.H.; Chang, B.C.; Fitch, J.P.; McCutchen-Maloney, S.L.
Proteomic characterization of Yersinia pestis virulence
J. Bacteriol.
187
8172-8180
2005
Yersinia pestis
Manually annotated by BRENDA team
Benedek, O.; Nagy, G.; Emody, L.
Intracellular signalling and cytoskeletal rearrangement involved in Yersinia pestis plasminogen activator (Pla) mediated HeLa cell invasion
Microb. Pathog.
37
47-54
2004
Yersinia pestis
Manually annotated by BRENDA team
Agarkov, A.; Chauhan, S.; Lory, P.J.; Gilbertson, S.R.; Motin, V.L.
Substrate specificity and screening of the integral membrane protease Pla
Bioorg. Med. Chem. Lett.
18
427-431
2008
Yersinia pestis (P17811), Yersinia pestis
Manually annotated by BRENDA team
Vranckx, L.; De Buck, E.; Anne, J.; Lammertyn, E.
Legionella pneumophila exhibits plasminogen activator activity
Microbiology
153
3757-3765
2007
Legionella pneumophila, Legionella pneumophila Philadelphia
Manually annotated by BRENDA team
Lathem, W.W.; Price, P.A.; Miller, V.L.; Goldman, W.E.
A plasminogen-activating protease specifically controls the development of primary pneumonic plague
Science
315
509-513
2007
Yersinia pestis (P17811), Yersinia pestis
Manually annotated by BRENDA team
Matero, P.; Pasanen, T.; Laukkanen, R.; Tissari, P.; Tarkka, E.; Vaara, M.; Skurnik, M.
Real-time multiplex PCR assay for detection of Yersinia pestis and Yersinia pseudotuberculosis
APMIS
117
34-44
2009
Yersinia pestis
Manually annotated by BRENDA team
Zhang, S.S.; Park, C.G.; Zhang, P.; Bartra, S.S.; Plano, G.V.; Klena, J.D.; Skurnik, M.; Hinnebusch, B.J.; Chen, T.
Plasminogen activator Pla of Yersinia pestis utilizes murine DEC-205 (CD205) as a receptor to promote dissemination
J. Biol. Chem.
283
31511-31521
2008
Yersinia pestis
Manually annotated by BRENDA team
Yun, T.; Morrissey, J.
Polyphosphate and omptins: Novel bacterial procoagulant agents
J. Cell. Mol. Med.
13
4146-4153
2009
Yersinia pestis
Manually annotated by BRENDA team
Tsang, T.M.; Felek, S.; Krukonis, E.S.
Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery
Infect. Immun.
78
3358-3368
2010
Yersinia pestis
Manually annotated by BRENDA team
Haiko, J.; Kukkonen, M.; Ravantti, J.J.; Westerlund-Wikstroem, B.; Korhonen, T.K.
The single substitution I259T, conserved in the plasminogen activator Pla of pandemic Yersinia pestis branches, enhances fibrinolytic activity
J. Bacteriol.
191
4758-4766
2009
Yersinia pestis
Manually annotated by BRENDA team
Feodorova, V.; Pankina, L.; Savostina, E.; Kuznetsov, O.; Konnov, N.; Sayapina, L.; Dentovskaya, S.; Shaikhutdinova, R.; Ageev, S.; Lindner, B.; Kondakova, A.; Kocharova, N.; Senchenkova, S.; Holst, O.; Pier, G.; Knirel, Y.; Anisimov, A.; Motin, V.
Yersinia pestis live vaccine with improved characteristics
Procedia Vaccinol.
1
97-100
2009
Yersinia pestis
-
Manually annotated by BRENDA team
Haiko, J.; Laakkonen, L.; Westerlund-Wikstroem, B.; Korhonen, T.K.
Molecular adaptation of a plant-bacterium outer membrane protease towards plague virulence factor Pla
BMC Evol. Biol.
11
43
2011
Yersinia pestis (P17811)
Manually annotated by BRENDA team
Eren, E.; Murphy, M.; Goguen, J.; van den Berg, B.
An active site water network in the plasminogen activator pla from Yersinia pestis
Structure
18
809-818
2010
Yersinia pestis (P17811), Yersinia pestis
Manually annotated by BRENDA team
Eren, E.; Van Den Berg, B.
Structural basis for activation of an integral membrane protease by lipopolysaccharide
J. Biol. Chem.
287
23971-23976
2012
Yersinia pestis (P17811)
Manually annotated by BRENDA team
Ruback, E.; Lobo, L.A.; Franca, T.C.; Pascutti, P.G.
Structural analysis of Pla protein from the biological warfare agent Yersinia pestis: docking and molecular dynamics of interactions with the mammalian plasminogen system
J. Biomol. Struct. Dyn.
31
477-484
2013
Yersinia pestis
Manually annotated by BRENDA team
Lane, M.C.; Lenz, J.D.; Miller, V.L.
Proteolytic processing of the Yersinia pestis YapG autotransporter by the omptin protease Pla and the contribution of YapG to murine plague pathogenesis
J. Med. Microbiol.
62
1124-1134
2013
Yersinia pestis (P17811)
Manually annotated by BRENDA team
van Lier, C.J.; Tiner, B.L.; Chauhan, S.; Motin, V.L.; Fitts, E.C.; Huante, M.B.; Endsley, J.J.; Ponnusamy, D.; Sha, J.; Chopra, A.K.
Further characterization of a highly attenuated Yersinia pestis CO92 mutant deleted for the genes encoding Braun lipoprotein and plasminogen activator protease in murine alveolar and primary human macrophages
Microb. Pathog.
80
27-38
2015
Yersinia pestis
Manually annotated by BRENDA team
Lawrenz, M.B.; Pennington, J.; Miller, V.L.
Acquisition of omptin reveals cryptic virulence function of autotransporter YapE in Yersinia pestis
Mol. Microbiol.
89
276-287
2013
Yersinia pestis (P17811)
Manually annotated by BRENDA team
Simon, S.; Demeure, C.; Lamourette, P.; Filali, S.; Plaisance, M.; Creminon, C.; Volland, H.; Carniel, E.
Fast and simple detection of Yersinia pestis applicable to field investigation of plague foci
PLoS ONE
8
e54947
2013
Yersinia pestis
Manually annotated by BRENDA team
Brannon, J.R.; Burk, D.L.; Leclerc, J.M.; Thomassin, J.L.; Portt, A.; Berghuis, A.M.; Gruenheid, S.; Le Moual, H.
Inhibition of outer membrane proteases of the omptin family by aprotinin
Infect. Immun.
83
2300-2311
2015
Yersinia pestis (P17811)
Manually annotated by BRENDA team
Smiley, S.T.; Szaba, F.M.; Kummer, L.W.; Duso, D.K.; Lin, J.S.
Yersinia pestis Pla protein thwarts T cell defense against plague
Infect. Immun.
87
e00126-19
2019
Yersinia pestis (P17811), Yersinia pestis, Yersinia pestis D27 (P17811)
Manually annotated by BRENDA team
Banerjee, S.K.; Huckuntod, S.D.; Mills, S.D.; Kurten, R.C.; Pechous, R.D.
Modeling pneumonic plague in human precision-cut lung slices highlights a role for the plasminogen activator protease in facilitating type 3 secretion
Infect. Immun.
87
e00175-19
2019
Yersinia pestis (P17811), Yersinia pestis
Manually annotated by BRENDA team
Korhonen, T.K.
Fibrinolytic and procoagulant activities of Yersinia pestis and Salmonella enterica
J. Thromb. Haemost.
13 Suppl 1
S115-S120
2015
Yersinia pestis (P17811)
Manually annotated by BRENDA team
Eddy, J.L.; Schroeder, J.A.; Zimbler, D.L.; Caulfield, A.J.; Lathem, W.W.
Proteolysis of plasminogen activator inhibitor-1 by Yersinia pestis remodulates the host environment to promote virulence
J. Thromb. Haemost.
14
1833-1843
2016
Yersinia pestis, Yersinia pestis CO92
Manually annotated by BRENDA team
Dentovskaya, S.V.; Platonov, M.E.; Svetoch, T.E.; Kopylov, P.K.; Kombarova, T.I.; Ivanov, S.A.; Shaikhutdinova, R.Z.; Kolombet, L.V.; Chauhan, S.; Ablamunits, V.G.; Motin, V.L.; Uversky, V.N.; Anisimov, A.P.
Two isoforms of Yersinia pestis plasminogen activator Pla intraspecies distribution, intrinsic disorder propensity, and contribution to virulence
PLoS ONE
11
e0168089
2016
Yersinia pestis subsp. microtus (A0A141BQM9), Yersinia pestis subsp. pestis (P17811), Yersinia pestis subsp. microtus 91001 (A0A141BQM9)
Manually annotated by BRENDA team
Feodorova, V.A.; Lyapina, A.M.; Zaitsev, S.S.; Khizhnyakova, M.A.; Sayapina, L.V.; Ulianova, O.V.; Ulyanov, S.S.; Motin, V.L.
New promising targets for synthetic omptin-based peptide vaccine against Gram-negative pathogens
Vaccines (Basel)
7
E36
2019
Yersinia pestis (P17811), Yersinia pestis CO92 (P17811)
Manually annotated by BRENDA team