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3.4.23.48: plasminogen activator Pla

This is an abbreviated version!
For detailed information about plasminogen activator Pla, go to the full flat file.

Word Map on EC 3.4.23.48

Reaction

Converts human Glu-plasminogen to plasmin by cleaving the Arg560-/-Val peptide bond that is also hydrolysed by the mammalian u-plasminogen activator and t-plasminogen activator. Also cleaves arginyl bonds in other proteins =

Synonyms

beta-Pla, coagulase, fibrinolysin, outer membrane protease, Pla, Pla protease, plasminogen activator, plasminogen activator Pla, plasminogen activator protease Pla, YapE

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.48 plasminogen activator Pla

Inhibitors

Inhibitors on EC 3.4.23.48 - plasminogen activator Pla

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Aprotinin
inhibits the recombinant enzyme expressed in Escherichia coli strain BL21 or DELTAcroP mutant strain of Citrobacter rodentium, in vivo. Docking model of the aprotinin-omptin complex. Lys15 of aprotinin interacts with Glu27 and Asp208 (OmpT numbering), which are the two negatively charged residues that form the S1 specificity pocket of omptins
PAI-1
-
inhibition of tissue-type plasminogen activator and urokinase
-
PAI-2
-
inhibition of urokinase
-
plasminogen activator inhibitor 1
additional information
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