3.4.23.46: memapsin 2
This is an abbreviated version!
For detailed information about memapsin 2, go to the full flat file.
Word Map on EC 3.4.23.46
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3.4.23.46
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alzheimer
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presenilins
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plaque
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abeta
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notch
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amyloid-beta
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tau
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deficit
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cerebral
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neurodegenerative
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dementia
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hippocampus
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early-onset
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amyloidogenic
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neuropathological
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adam10
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beta-peptide
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intramembrane
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neurofibrillary
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synaptic
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neuritic
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tangle
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neuroblastoma
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cortical
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nicastrin
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psen1
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neurotoxic
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senile
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neuroprotective
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csf
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sh-sy5y
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epsilon4
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hyperphosphorylation
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endoproteolysis
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anti-ad
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maze
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ad-related
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disintegrin
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analysis
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ectodomain
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holoproteins
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anti-alzheimer
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beta-protein
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dapt
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insulin-degrading
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medicine
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swedish
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ad-like
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pharmacology
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abeta1-42
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neprilysin
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amyloidogenesis
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angiopathy
- 3.4.23.46
- alzheimer
-
presenilins
- plaque
- abeta
- notch
- amyloid-beta
- tau
- deficit
- cerebral
- neurodegenerative
- dementia
- hippocampus
-
early-onset
-
amyloidogenic
-
neuropathological
- adam10
- beta-peptide
-
intramembrane
-
neurofibrillary
- synaptic
-
neuritic
- tangle
- neuroblastoma
- cortical
-
nicastrin
- psen1
-
neurotoxic
-
senile
-
neuroprotective
- csf
-
sh-sy5y
-
epsilon4
-
hyperphosphorylation
-
endoproteolysis
-
anti-ad
-
maze
-
ad-related
-
disintegrin
- analysis
- ectodomain
-
holoproteins
-
anti-alzheimer
- beta-protein
- dapt
-
insulin-degrading
- medicine
-
swedish
-
ad-like
- pharmacology
- abeta1-42
- neprilysin
-
amyloidogenesis
- angiopathy
Reaction
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =
Synonyms
alpha-secretase, amyloid precursor protein secretase, APP secretase, Asec-1A, aspartic protease BACE, aspartic protease BACE1, Aspartic proteinase, aspartic proteinase BACE1, BACE, BACE 1, BACE I, BACE-1, BACE-2, BACE1, BACE1/beta-secretase, BACE2, beta protein amyloidogenase, beta secretase, beta-amyloid cleaving enzyme, beta-amyloid cleaving enzyme 1, beta-amyloid cleaving enzyme-1, beta-amyloid precursor protein cleavage enzyme 1, beta-amyloid precursor protein cleaving enzyme, beta-amyloid protein precursor secretase, beta-amyloid-cleaving enzyme, beta-amyloid-converting enzyme-1, beta-APP cleaving enzyme 1, beta-secretase, beta-secretase enzyme 1, beta-secretase-1, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1), beta-site amyloid cleaving enzyme, beta-site amyloid precursor protein cleavage enzyme, beta-site amyloid precursor protein cleaving enzyme, beta-site amyloid precursor protein cleaving enzyme 1, beta-site amyloid precursor protein cleaving enzyme-1, beta-site amyloid precursor protein enzyme 1, beta-site amyloid precursor protein-cleaving enzyme, beta-site amyloid precursor protein-cleaving enzyme 1, beta-site APP (amyloid precursor protein) cleaving enzyme, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 1, beta-site APP cleaving enzyme-1, beta-site APP-cleaving enzyme 1, D-aspartyl-beta-amyloid secretase, gamma-secretase, memapsin 1, memapsin 2, memapsin2, membrane-bound aspartic protease, NACE1, presenilin 1, presenilin-1, presenilin-2, protease Asp2, proteinase BACE1
ECTree
3.4.23.46 memapsin 2Advanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.23.46 - memapsin 2
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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astrocytic BACE1 expression may be important to the development of pathology in Alzheimer's disease
glioblastoma-astrocytoma cell line U373, nuclear extracts used for promoter-protein binding studies
HEK-293 cell transfected with a Swedish mutant APP695 K595N/M596L
U937, nuclear extracts used for promoter-protein binding studies
NB, nuclear extracts used for promoter-protein binding studies
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membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Platelets from individuals with Alzheimer's disease or mild cognitive impairment are significantly more likely to lie within the negative correlation zone than control platelets
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BACE1 is expressed exclusively in neurons but not in glial cells. BACE1 is increased in remaining neurons in Alzheimer's disease brains
Alzheimer disease patients, endogenous processing of beta2 subunit of voltage-gated sodium channel found to be increased
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both BACE1 and human cathepsin D show poor activity towards the wild-type amyloid beta-site sequence
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levels of gamma- and beta-secretase activities are greater in brain tissue samples from Alzheimer's disease patients compared to non-demented control subjects
cleavage products of BACE1 determined, sodium-current densities reduced in neuroblastoma cells and hippocampal cells of transgenic mice
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samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. BACE1 activity shows a significant positive correlation with the amount of extractable amyloid beta-peptide, and BACE1 protein and activity are significantly increased in cases of alzheimer's disease
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development of assay for cerebrospinal fluid beta-secretase-1 activity with sensitivity down to 1 pM of recombinant enzyme. Endogenous secretase-1 enzyme appears to exist as a C-terminally truncated protein. A small cohort of human subjects displays age-dependent increase in cerebrospinal fluid beta-secretase-1 activity. In Alzheimer's disease subjects, a significant decline in age-adjusted cerebrospinal fluid beta-secretase-1 activity is observed
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BACE1 is significantly and time-dependently increased in the ipsilateral striatum
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changes in caspase-3, amyloid beta and BACE1 levels are detected in rat striatum on different days after middle cerebral artery occlusion using immunostaining. The positive labeled cells of activated caspase-3, amyloid beta, and BACE1 are significantly and time-dependently increased in the ipsilateral striatum
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immortalized mouse embryonic fibroblasts from wild-type, and presenilin-deficient PS1-/-, PS2-/-, PS1-/-/PS2-/- mice. Oxidative stress fails to induce BACE1 expression in presenilin-1 deficient cells
stably expressing human BACE1 enzyme, used for inhibition assay
nuclear extracts used for promoter-protein binding studies, hypoxic cells included
expression of BACE1 in CA1 and C3 regions analyzed under combination of chronic stress and ovariectomy
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BACE1 is expressed exclusively in neurons but not in glial cells. BACE1 is increased in remaining neurons in Alzheimer's disease brains
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in cells overexpressing amyloid precursor protein, thiamine deficiency promotes maturation of beta-site amyloid precursor protein cleaving enzyme 1, BACE1 and increases beta-secretase activity which results in elevated levels of beta-amyloid as well as beta-secretase cleaved C-terminal fragment. An inhibitor of beta-secretase efficiently reduces thiamine deficiency-induced up-regulation of amyloid beta and beta-secretase cleaved fragment
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membrane cholesterol significantly influences membrane beta-secretase activity in a biphasic manner, with positive correlations at higher membrane cholesterol levels, and negative correlations at lower membrane cholesterol levels. Pharmacological inhibition of SH-SY5Y beta-secretase activity results in increased membrane cholesterol levels
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oxidative stress fails to induce BACE1 expression in cells treated with gamma-secretase inhibitors. Oxidative stress-induced beta-secretase activity and soluble beta amyloid precursor protein levels are suppressed by gamma-secretase inhibitors
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addition of a GPI-anchor to BACE targets the enzyme exclusively to lipid raft domains
