3.4.23.46: memapsin 2

This is an abbreviated version!
For detailed information about memapsin 2, go to the full flat file.

Word Map on EC 3.4.23.46

3.4.23.46

alzheimer

presenilins

plaque

abeta

notch

amyloid-beta

tau

deficit

cerebral

neurodegenerative

dementia

hippocampus

early-onset

amyloidogenic

neuropathological

adam10

beta-peptide

intramembrane

neurofibrillary

synaptic

neuritic

tangle

neuroblastoma

cortical

nicastrin

psen1

neurotoxic

senile

neuroprotective

csf

sh-sy5y

epsilon4

hyperphosphorylation

endoproteolysis

anti-ad

maze

ad-related

disintegrin

analysis

ectodomain

holoproteins

anti-alzheimer

beta-protein

dapt

insulin-degrading

medicine

swedish

ad-like

pharmacology

abeta1-42

neprilysin

amyloidogenesis

angiopathy

Reaction

broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =

Synonyms

alpha-secretase, amyloid precursor protein secretase, APP secretase, Asec-1A, aspartic protease BACE, aspartic protease BACE1, Aspartic proteinase, aspartic proteinase BACE1, BACE, BACE 1, BACE I, BACE-1, BACE-2, BACE1, BACE1/beta-secretase, BACE2, beta protein amyloidogenase, beta secretase, beta-amyloid cleaving enzyme, beta-amyloid cleaving enzyme 1, beta-amyloid cleaving enzyme-1, beta-amyloid precursor protein cleavage enzyme 1, beta-amyloid precursor protein cleaving enzyme, beta-amyloid protein precursor secretase, beta-amyloid-cleaving enzyme, beta-amyloid-converting enzyme-1, beta-APP cleaving enzyme 1, beta-secretase, beta-secretase enzyme 1, beta-secretase-1, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1), beta-site amyloid cleaving enzyme, beta-site amyloid precursor protein cleavage enzyme, beta-site amyloid precursor protein cleaving enzyme, beta-site amyloid precursor protein cleaving enzyme 1, beta-site amyloid precursor protein cleaving enzyme-1, beta-site amyloid precursor protein enzyme 1, beta-site amyloid precursor protein-cleaving enzyme, beta-site amyloid precursor protein-cleaving enzyme 1, beta-site APP (amyloid precursor protein) cleaving enzyme, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 1, beta-site APP cleaving enzyme-1, beta-site APP-cleaving enzyme 1, D-aspartyl-beta-amyloid secretase, gamma-secretase, memapsin 1, memapsin 2, memapsin2, membrane-bound aspartic protease, NACE1, presenilin 1, presenilin-1, presenilin-2, protease Asp2, proteinase BACE1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.46 memapsin 2

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Results	in table
21	Activating Compound
1083	AA Sequence
35	Application
1	CAS Registry Number
27	Cloned(Commentary)
27	Crystallization (Commentary)
7484	Disease/ Diagnostics
21	Expression
15	General Information
419	IC50 Value
715	Inhibitors
3	kcat/KM [mM/s]
76	Ki Value [mM]
12	KM Value [mM]
27	Localization
2	Metals/Ions
4	Molecular Weight [Da]
151	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
196	Organism
696	PDB ID
5	pH Optimum
2	pH Range
1	Posttranslational Modification
19	Protein Variants
5	Purification (Commentary)
6	Reaction
193	Reference
1	Renatured (Commentary)
132	Source Tissue
21	Specific Activity [micromol/min/mg]
272	Substrates and Products (Substrate)
4	Subunits
266	Synonyms
3	Temperature Optimum [°C]
6	Turnover Number [1/s]

Sequence

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Sequence on EC 3.4.23.46 - memapsin 2

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Q2HJ40 pBLAST

BACE1_BOVIN

Bos taurus

501

55725

Swiss-Prot