3.4.23.46: memapsin 2

This is an abbreviated version!
For detailed information about memapsin 2, go to the full flat file.

Reaction

broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =

Synonyms

alpha-secretase, amyloid precursor protein secretase, APP secretase, Asec-1A, aspartic protease BACE, aspartic protease BACE1, Aspartic proteinase, aspartic proteinase BACE1, BACE, BACE 1, BACE I, BACE-1, BACE-2, BACE1, BACE1/beta-secretase, BACE2, beta protein amyloidogenase, beta secretase, beta-amyloid cleaving enzyme, beta-amyloid cleaving enzyme 1, beta-amyloid cleaving enzyme-1, beta-amyloid precursor protein cleavage enzyme 1, beta-amyloid precursor protein cleaving enzyme, beta-amyloid protein precursor secretase, beta-amyloid-cleaving enzyme, beta-amyloid-converting enzyme-1, beta-APP cleaving enzyme 1, beta-secretase, beta-secretase enzyme 1, beta-secretase-1, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1), beta-site amyloid cleaving enzyme, beta-site amyloid precursor protein cleavage enzyme, beta-site amyloid precursor protein cleaving enzyme, beta-site amyloid precursor protein cleaving enzyme 1, beta-site amyloid precursor protein cleaving enzyme-1, beta-site amyloid precursor protein enzyme 1, beta-site amyloid precursor protein-cleaving enzyme, beta-site amyloid precursor protein-cleaving enzyme 1, beta-site APP (amyloid precursor protein) cleaving enzyme, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 1, beta-site APP cleaving enzyme-1, beta-site APP-cleaving enzyme 1, D-aspartyl-beta-amyloid secretase, gamma-secretase, memapsin 1, memapsin 2, memapsin2, membrane-bound aspartic protease, NACE1, presenilin 1, presenilin-1, presenilin-2, protease Asp2, proteinase BACE1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.46 memapsin 2

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Results	in table
21	Activating Compound
1083	AA Sequence
35	Application
1	CAS Registry Number
27	Cloned(Commentary)
27	Crystallization (Commentary)
7484	Disease/ Diagnostics
21	Expression
15	General Information
419	IC50 Value
715	Inhibitors
3	kcat/KM [mM/s]
76	Ki Value [mM]
12	KM Value [mM]
27	Localization
2	Metals/Ions
4	Molecular Weight [Da]
151	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
196	Organism
696	PDB ID
5	pH Optimum
2	pH Range
1	Posttranslational Modification
19	Protein Variants
5	Purification (Commentary)
6	Reaction
193	Reference
1	Renatured (Commentary)
132	Source Tissue
21	Specific Activity [micromol/min/mg]
272	Substrates and Products (Substrate)
4	Subunits
266	Synonyms
3	Temperature Optimum [°C]
6	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.23.46 - memapsin 2

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

amyloid -like PROTEIN 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

amyloid beta-precursor protein + H2O

?

2 entries

amyloid pbeta A4 protein + H2O

?

Homo sapiens

-

-

713355

-

-

?

amyloid precursor protein + H2O

?

2 entries

amyloid precursor protein + H2O

amyloid beta protein 40 + amyloid beta protein 42

Danio rerio

-

-

711587

-

-

?

amyloid precursor protein + H2O

beta-amyloid peptide 40 + beta-amyloid peptide 42

Homo sapiens

-

-

712447

-

-

?

amyloid precursor protein + H2O

C-terminal fragment + soluble N-terminal fragment APPbeta

Homo sapiens

-

-

700413

-

-

?

amyloid precursor protein + H2O

C-terminal fragment C99 of amyloid precursor protein + ?

Homo sapiens

-

-

709626

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

12 entries

amyloid precursor protein + H2O

neurotrophic soluble amyloid precursor protein + ?

Rattus norvegicus

-

-

711929

-

-

?

amyloid precursor protein-DELTANL + H2O

?

Homo sapiens

-

the Swedish familial mutation in APP (DELTANL) enhances beta-secretase cleavage

712811

-

-

?

amyloid-beta precursor protein + H2O

?

6 entries

amyloid-beta precursor protein + H2O

amyloid-beta protein 40 + amyloid-beta protein 42

Rattus norvegicus

-

-

713110

-

-

?

amyloid-beta precursor protein + H2O

fragments of amyloid-beta precursor protein

2 entries

amyloid-like protein 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

basigin + H2O

?

Homo sapiens

-

-

713355

-

-

?

beta subunit of voltage-gated sodium channel + H2O

?

Mus musculus

-

-

669344

-

-

?

beta-amyloid precursor protein + H2O

fragments of amyloid precursor protein

2 entries

beta-amyloid precursor protein + H2O

fragments of beta-amyloid precursor protein

2 entries

beta-secretase 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

beta2 subunit of voltage-gated sodium channel + H2O

?

2 entries

BMP and activin membrane-bound inhibitor homolog + H2O

?

Homo sapiens

-

-

713355

-

-

?

cache domain containing 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

carboxypeptidase D + H2O

?

Homo sapiens

-

-

713355

-

-

?

cation-independent mannose-6-phosphate receptor + H2O

?

Homo sapiens

-

-

713355

-

-

?

CD166 antigen + H2O

?

Homo sapiens

-

-

713355

-

-

?

CD276 antigen + H2O

?

Homo sapiens

-

-

713355

-

-

?

CD44 + H2O

?

Rattus norvegicus

-

-

713110

-

-

?

chondroitin sulfate proteoglycan 4 + H2O

?

Homo sapiens

-

-

713355

-

-

?

contactin-1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

cysteine-rich motor neuron 1 protein + H2O

?

Homo sapiens

-

-

713355

-

-

?

desmoglein 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

disintegrin and metalloproteinase domain-containing protein 10 + H2O

?

Homo sapiens

-

-

713355

-

-

?

E-cadherin + H2O

?

Rattus norvegicus

-

-

713110

-

-

?

ephrin type-A receptor 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

ephrin type-A receptor 4 + H2O

?

Homo sapiens

-

-

713355

-

-

?

ephrin type-A receptor 7 + H2O

?

Homo sapiens

-

-

713355

-

-

?

ephrin-A5 + H2O

?

Homo sapiens

-

-

713355

-

-

?

ErbB4 + H2O

?

Rattus norvegicus

-

-

713110

-

-

?

glypican-3 + H2O

?

Homo sapiens

-

-

713355

-

-

?

Golgi apparatus protein 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

Golgi phosphoprotein 4 + H2O

?

Homo sapiens

-

-

713355

-

-

?

hepatocyte growth factor receptor + H2O

?

Homo sapiens

-

-

713355

-

-

?

HLA class I histocompatibility antigen (combined) + H2O

?

Homo sapiens

-

-

713355

-

-

?

interleukin-6 receptor beta chain + H2O

?

Homo sapiens

-

-

713355

-

-

?

Jagged-1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

Klotho protein + H2O

?

Homo sapiens

-

-

712012

-

-

?

Kunitz-type protease inhibitor 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

leucin-rich repeats and immunoglobulin-like domains protein 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

leucin-rich repeats and immunoglobulin-like domains protein 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

leucin-rich repeats and immunoglobulin-like domains protein 3 + H2O

?

Homo sapiens

-

-

713355

-

-

?

leucine-rich repeat-containing protein 33 + H2O

?

Homo sapiens

-

-

713355

-

-

?

low-density lipoprotein receptor-related protein 11 + H2O

?

Homo sapiens

-

-

713355

-

-

?

low-density lipoprotein receptor-related protein 4 + H2O

?

Homo sapiens

-

-

713355

-

-

?

membrane-bound prostaglandin E2 synthase-2 + H2O

?

Homo sapiens

-

BACE-1 is involved in the cleavage of membrane-bound prostaglandin E2 synthase-2 in its N-terminal portion, which, in turn, enhances the generation of prostaglandin E2

711093

-

-

?

N-cadherin + H2O

?

Homo sapiens

-

-

712447

-

-

?

neogenin + H2O

?

Homo sapiens

-

-

713355

-

-

?

netrin receptor UNC5C + H2O

?

Homo sapiens

-

-

713355

-

-

?

neuronal cell adhesion molecule 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

neuronal cell adhesion molecule L1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

Notch + H2O

Notch intracellular domain + ?

Danio rerio

-

-

711587

-

-

?

Notch protein + H2O

?

Homo sapiens

-

-

712447

-

-

?

Notch-1 + H2O

?

Rattus norvegicus

-

-

713110

-

-

?

peptidyl-glycine alpha-amidating monooxygenase + H2O

?

Homo sapiens

-

-

713355

-

-

?

plexin domain-containing protein 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

podocalyxin-like protein 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

poliovirus receptor type I + H2O

?

Homo sapiens

-

-

713355

-

-

?

protocadherin 21 + H2O

?

Homo sapiens

-

-

713355

-

-

?

protocadherin 7 + H2O

?

Homo sapiens

-

-

713355

-

-

?

protocadherin gamma A11 + H2O

?

Homo sapiens

-

-

713355

-

-

?

protocadherin gamma A5 + H2O

?

Homo sapiens

-

-

713355

-

-

?

protocadherin gamma A8 + H2O

?

Homo sapiens

-

-

713355

-

-

?

protocadherin gamma C3 + H2O

?

Homo sapiens

-

-

713355

-

-

?

protogenin + H2O

?

Homo sapiens

-

-

713355

-

-

?

receptor protein tyrosine kinase variant EPHB4V1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

receptor-type tyrosin-protein phosphatase S + H2O

?

Homo sapiens

-

-

713355

-

-

?

rhodamine-EVNLDAEFK-quencher + H2O

?

Homo sapiens

-

-

711382

-

-

?

roundabout homolog 1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

roundabout homolog 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

seizure 6-like protein 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

semaphorin-4B + H2O

?

Homo sapiens

-

-

713355

-

-

?

semaphorin-4C + H2O

?

Homo sapiens

-

-

713355

-

-

?

semaphorin-6A + H2O

?

Homo sapiens

-

-

713355

-

-

?

semaphorin-6D + H2O

?

Homo sapiens

-

-

713355

-

-

?

sidekick-1 + H2O

?

Homo sapiens

-

-

713355

-

-

?

sidekick-2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

sortilin type I + H2O

?

Homo sapiens

-

-

713355

-

-

?

sortilin-related receptor type I + H2O

?

Homo sapiens

-

-

713355

-

-

?

Swedish mutation of amyloid precursor protein + H2O

fragments of Swedish mutation of amyloid precursor protein

Homo sapiens

-

-

712842

-

-

?

syndecan-4 + H2O

?

Homo sapiens

-

-

713355

-

-

?

T-cell immunomodulatory protein + H2O

?

Homo sapiens

-

-

713355

-

-

?

toll-like receptor 9 + H2O

?

Homo sapiens

-

-

713355

-

-

?

trans-Golgi network integral membrane protein 2 + H2O

?

Homo sapiens

-

-

713355

-

-

?

transmembrane protein 132A + H2O

?

Homo sapiens

-

-

713355

-

-

?

tumor necrosis factor receptor superfamily member 21 + H2O

?

Homo sapiens

-

-

713355

-

-

?

vesicular integral-membrane protein VIP36 + H2O

?

Homo sapiens

-

-

713355

-

-

?

additional information

?

-

5 entries

amyloid beta-precursor protein + H2O

?

Homo sapiens

P56817

-

683469

-

-

?

amyloid beta-precursor protein + H2O

?

Mus musculus

-

BACE1 and the amyloid beta-precursor protein processing pathway are critical for cognitive, emotional and synaptic functions

669947

-

-

?

amyloid precursor protein + H2O

?

Homo sapiens

-

-

712078

-

-

?

amyloid precursor protein + H2O

?

Rattus norvegicus

-

first step in generation of the Abeta peptide is the cleavage of amyloid precursor protein by BACE1. BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper. BACE1 provides a link between metal homoeostasis and oxidative stress in Alzheimer disease

669332

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Cricetulus griseus

-

-

711091

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

-

711093, 711404, 711410, 711412, 711634, 711905, 711906, 711943, 712012, 712229, 712430, 712688, 712693

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

P56817

-

712693

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

-

713114, 713121

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

P56817

-

711450, 712812

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

amyloid precursor protein is cleaved at the N-terminus of Abeta by beta-secretase yielding a slightly shorter soluble APPbeta fragment and a slightly longer CTFbeta fragment (also termed C99)

711821

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

BACE1 cleaves amyloid precursor protein at the beta-site

712811

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

beta-secretase cleavage produces s-amyloid precursor protein-beta and the beta-C-terminal fragment C99. ATXN1 loss of function potentiates BACE1 cleavage of amyloid precursor protein

712492

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

cleavage by beta-secretase at the N-terminus of the Abeta domain produces a fragment known as soluble beta-amyloid precursor protein and the remaining cell membrane spanning fragment of amyloid precursor protein (C99)

711944

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Mus musculus

-

-

710808, 711918

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Mus musculus

-

BACE1 cleaves APP at the N-terminal end of the Abeta sequence, producing a 14000 Da C-terminal fragment beta or C99

712831

-

-

?

amyloid precursor protein + H2O

fragments of amyloid precursor protein

Rattus norvegicus

-

-

711927, 713123

-

-

?

amyloid-beta precursor protein + H2O

?

Homo sapiens

P56817

-

752947, 752962, 753008, 753281

-

-

?

amyloid-beta precursor protein + H2O

?

Homo sapiens

-

-

753281

-

-

?

amyloid-beta precursor protein + H2O

?

Homo sapiens

P56817

-

753331, 753489, 753490, 753620, 753969, 754204, 754403, 754489, 754688, 754905

-

-

?

amyloid-beta precursor protein + H2O

?

Mus musculus

P56818

-

753126, 754384, 754736

-

-

?

amyloid-beta precursor protein + H2O

?

Mus musculus

-

-

754736

-

-

?

amyloid-beta precursor protein + H2O

?

Mus musculus

P56818

-

754895

-

-

?

amyloid-beta precursor protein + H2O

fragments of amyloid-beta precursor protein

Homo sapiens

-

-

713117

-

-

?

amyloid-beta precursor protein + H2O

fragments of amyloid-beta precursor protein

Rattus norvegicus

-

beta-secretase first cleaves the ectodomain of amyloid-beta precursor protein to generate a membrane-bound fragment

713549

-

-

?

beta-amyloid precursor protein + H2O

fragments of amyloid precursor protein

Cricetulus griseus

-

the loss of Niemann-Pick type C1 increases beta-secretase cleavage of beta-amyloid precursor protein

711303

-

-

?

beta-amyloid precursor protein + H2O

fragments of amyloid precursor protein

Homo sapiens

-

-

711390, 711403

-

-

?

beta-amyloid precursor protein + H2O

fragments of beta-amyloid precursor protein

Cricetulus griseus

-

-

711303

-

-

?

beta-amyloid precursor protein + H2O

fragments of beta-amyloid precursor protein

Homo sapiens

-

-

711981

-

-

?

beta2 subunit of voltage-gated sodium channel + H2O

?

Homo sapiens

P56817

-

683908

-

-

?

beta2 subunit of voltage-gated sodium channel + H2O

?

Mus musculus

P56818

-

683908

-

-

?

additional information

?

-

Homo sapiens

-

broad endopeptidase specificity, cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein

638904

-

-

?

additional information

?

-

Homo sapiens

-

cleaves at the beta-secretase site of Alzheimer's amyloid precursor protein

638909

-

-

?

additional information

?

-

Homo sapiens

-

beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling

669953

-

-

?

additional information

?

-

Homo sapiens

-

caveolin 1 and flotillin 1 may modulate beta-secretase activity by interacting with BACE1

669961

-

-

?

additional information

?

-

Mus musculus

-

BACE1 is required for myelination and correct bundling of axons by Schwann cell most likely via processing of type III neuregulin 1

670889

-

-

?