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3.4.23.46: memapsin 2

This is an abbreviated version!
For detailed information about memapsin 2, go to the full flat file.

Word Map on EC 3.4.23.46

Reaction

broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =

Synonyms

alpha-secretase, amyloid precursor protein secretase, APP secretase, Asec-1A, aspartic protease BACE, aspartic protease BACE1, Aspartic proteinase, aspartic proteinase BACE1, BACE, BACE 1, BACE I, BACE-1, BACE-2, BACE1, BACE1/beta-secretase, BACE2, beta protein amyloidogenase, beta secretase, beta-amyloid cleaving enzyme, beta-amyloid cleaving enzyme 1, beta-amyloid cleaving enzyme-1, beta-amyloid precursor protein cleavage enzyme 1, beta-amyloid precursor protein cleaving enzyme, beta-amyloid protein precursor secretase, beta-amyloid-cleaving enzyme, beta-amyloid-converting enzyme-1, beta-APP cleaving enzyme 1, beta-secretase, beta-secretase enzyme 1, beta-secretase-1, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1), beta-site amyloid cleaving enzyme, beta-site amyloid precursor protein cleavage enzyme, beta-site amyloid precursor protein cleaving enzyme, beta-site amyloid precursor protein cleaving enzyme 1, beta-site amyloid precursor protein cleaving enzyme-1, beta-site amyloid precursor protein enzyme 1, beta-site amyloid precursor protein-cleaving enzyme, beta-site amyloid precursor protein-cleaving enzyme 1, beta-site APP (amyloid precursor protein) cleaving enzyme, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 1, beta-site APP cleaving enzyme-1, beta-site APP-cleaving enzyme 1, D-aspartyl-beta-amyloid secretase, gamma-secretase, memapsin 1, memapsin 2, memapsin2, membrane-bound aspartic protease, NACE1, presenilin 1, presenilin-1, presenilin-2, protease Asp2, proteinase BACE1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.46 memapsin 2

IC50 Value

IC50 Value on EC 3.4.23.46 - memapsin 2

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.2197
(+)-byakangelicin
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.1049
(+)-byakangelicol
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.03359
(+)-corynoline
Homo sapiens
at pH 4.0 and 25°C
0.00225
(+)-N-((4S,4aS,6S,8aR)-10-amino-4,4a,5,6,7,8-hexahydro-1H,3H-4,8a-(epithiomethenoazeno)isochromen-6-yl)-3-chlorobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.3592
(+)-oxypeucedanin
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.04116
(-)-corycavamine
Homo sapiens
at pH 4.0 and 25°C
0.00311 - 0.1275
(-)-gallocatechin gallate
0.00017 - 0.0008
(1R,3S)-3-[(1S)-1-(acetylamino)-2-methylpropyl]-N-[(2S,3S,5R)-6-(butylamino)-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl]cyclohexanecarboxamide
0.0015 - 0.0027
(1R,3S)-3-[1-(acetylamino)cyclopentyl]-N-[(2S,3S,5R)-6-(butylamino)-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl]cyclohexanecarboxamide
0.0038 - 0.0042
(1R,3S)-3-[2-(acetylamino)propan-2-yl]-N-[(2S,3S)-3-hydroxy-1-phenyl-4-[[3-(propan-2-yl)benzyl]amino]butan-2-yl]cyclohexanecarboxamide
0.00037 - 0.0037
(1R,3S)-3-[2-(acetylamino)propan-2-yl]-N-[(2S,3S,5R)-6-(butylamino)-3-hydroxy-5-methyl-6-oxo-1-phenylhexan-2-yl]cyclohexanecarboxamide
0.0000025 - 0.00014
(1R,3S)-N-[(2S,3S)-3-hydroxy-1-phenyl-4-[[3-(propan-2-yl)benzyl]amino]butan-2-yl]-3-[2-(2-oxopiperidin-1-yl)propan-2-yl]cyclohexanecarboxamide
0.000025 - 0.00096
(1R,3S)-N-[(2S,3S)-3-hydroxy-1-phenyl-4-[[3-(propan-2-yl)benzyl]amino]butan-2-yl]-3-[2-(2-oxopyrrolidin-1-yl)propan-2-yl]cyclohexanecarboxamide
0.00058 - 0.0037
(1R,3S)-N-[(2S,3S)-3-hydroxy-1-phenyl-4-[[3-(propan-2-yl)benzyl]amino]butan-2-yl]-3-[2-(propanoylamino)propan-2-yl]cyclohexanecarboxamide
0.00015 - 0.0002
(1R,3S)-N-[(2S,3S)-3-hydroxy-1-phenyl-4-[[3-(propan-2-yl)benzyl]amino]butan-2-yl]-3-[2-[methyl(propanoyl)amino]propan-2-yl]cyclohexanecarboxamide
0.000511
(1S,2R)-N-[1-benzyl-2-hydroxy-3-(S)-[(1-benzylpiperidin-4-yl)amino]-propyl]-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
pH 4.0
0.000222
(1S,2R)-N-[1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl]-5-[methyl(methylsulfonyl)-amino]-N'-[(R)-1-(4-fluorophenyl)ethyl]isophthalamide
Homo sapiens
-
pH 4.0
0.000567
(1S,2R)-N-[1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl]-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
pH 4.0
0.00015
(2R,4S)-N-butyl-4-hydroxy-2-methyl-4-[(2S,5S,7R)-1,2,7-trimethyl-3,16-dioxo-1,4-diazacyclohexadecan-5-yl]butanamide
Homo sapiens
-
0.00059
(2R,4S)-N-butyl-4-[(2S,5S,7R)-2,7-dimethyl-3,15-dioxo-1,4-diazacyclopentadecan-5-yl]-4-hydroxy-2-methylbutanamide
Homo sapiens
-
0.00025
(2R,4S)-N-butyl-4-[(2S,5S,7R)-2,7-dimethyl-3,16-dioxo-1,4-diazacyclohexadecan-5-yl]-4-hydroxy-2-methylbutanamide
Homo sapiens
-
0.000008
(2S)-2-((3R)-3-acetamido-3-isobutyl-2-oxo-1-pyrrolidinyl)-N-((1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-2-(1,2,3,4-tetrahydro-3-isoquinolinyl)ethyl)-4-phenylbutanamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0056
(2S,5S,8S,11S,14S)-14-amino-5-benzyl-8-(cyclohexylmethyl)-16-(5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-2-hydroxy-11-(1-methylethyl)-4,7,10,13,16-pentaoxo-N-[3-(2H-tetrazol-5-yl)phenyl]-3,6,9,12-tetraazahexadecan-1-amide
Homo sapiens
i.e. KMI-574, used as a substrate transition-state mimic
0.000022
(3S,14R,16S)-16-[(1R)-1-hydroxy-2-([3-(1-methylethyl)benzyl]amino)ethyl]-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5-dione
Homo sapiens
-
0.000002
(3S,14R,16S)-16-[(1S)-2-[[(1R)-3,3-dimethyl-7-(1-methylethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]-1-hydroxyethyl]-3,4,14-trimethyl-1,4-diazacyclohexadecane-2,5-dione
Homo sapiens
-
0.00001
(3S,5R)-3-(4-amino-3-fluoro-5-[[(2R)-1,1,1-trifluoro-3-hydroxypropan-2-yl]oxy]benzyl)-5-[(3-tert-butylbenzyl)amino]-4-hydroxytetrahydro-2H-thiopyranium-1-olate
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00107
(4aR,6R,8aS)-8a-(2,4-difluorophenyl)-6-(fluoromethyl)-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-amine
Homo sapiens
pH 4.5, 37°C
0.000045
(4aS,4'S,10aR)-8-(2-fluoropyridin-3-yl)-4a-methyl-3,4,4a,10a-tetrahydro-2H,5'H-spiro[pyrano[3,2-b]chromene-10,4'-thiazol]-2'-amine
Homo sapiens
pH 4.4, 22°C
0.00015
(4S)-4-(2,4-difluorophenyl)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Mus musculus
pH and temperature not specified in the publication
0.000001
(4S)-4-[(1R)-1-hydroxy-2-([1-[3-(propan-2-yl)phenyl]cyclopropyl]amino)ethyl]-19-(2-oxopyrrolidin-1-yl)-11,16-dioxa-3-azatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000009
(4S)-4-[(1R)-1-hydroxy-2-([1-[3-(propan-2-yl)phenyl]cyclopropyl]amino)ethyl]-19-(methoxymethyl)-11,16-dioxa-3,18-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000017
(4S)-4-[(1R)-1-hydroxy-2-([1-[3-(propan-2-yl)phenyl]cyclopropyl]amino)ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000083
(4S)-4-[(1R)-1-hydroxy-2-([1-[3-(propan-2-yl)phenyl]ethyl]amino)ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
(4S)-4-[(1R)-1-hydroxy-2-([2-[3-(propan-2-yl)phenyl]propan-2-yl]amino)ethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000292
(4S)-4-[(1R)-1-hydroxy-2-[[3-(propan-2-yl)benzyl]amino]ethyl]-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
(4S)-4-[(1R)-1-hydroxy-2-[[3-(propan-2-yl)benzyl]amino]ethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000042
(4S)-4-[(1R)-1-hydroxy-2-[[3-(propan-2-yl)benzyl]amino]ethyl]-19-methyl-11,16-dioxa-3,18-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000027
(4S)-4-[(1R)-1-hydroxy-2-[[3-(propan-2-yl)benzyl]amino]ethyl]-19-methyl-11-oxa-3,16,18-triazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.01
(4S)-4-[(1R)-2-[[1-(3-tert-butylphenyl)-2,2,2-trifluoroethyl]amino]-1-hydroxyethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
IC50 above 0.01 mM, pH and temperature not specified in the publication
0.000177
(4S)-4-[(1R)-2-[[1-(3-tert-butylphenyl)-2-fluoroethyl]amino]-1-hydroxyethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000668
(4S)-4-[(1R)-2-[[1-(3-tert-butylphenyl)-2-methoxyethyl]amino]-1-hydroxyethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000067
(4S)-4-[(1R)-2-[[1-(3-tert-butylphenyl)cyclobutyl]amino]-1-hydroxyethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
(4S)-4-[(1R)-2-[[1-(3-tert-butylphenyl)cyclopentyl]amino]-1-hydroxyethyl]-19-(methoxymethyl)-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-2-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
(4S)-4-[2,4-difluoro-5-(pyrimidin-5-yl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
Mus musculus
pH and temperature not specified in the publication
0.00031
(4S,6R)-4-(2,4-difluorophenyl)-4-methyl-6-(pyrimidin-5-yl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Mus musculus
pH and temperature not specified in the publication
0.00002
(5S)-2-amino-5-(2',4'-difluorobiphenyl-3-yl)-3-methyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.00001
(5S)-2-amino-5-[3-fluoro-5-(2-fluoropyridin-3-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.039
(6R)-2,6-anhydro-5-O-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-[2-[(2R)-2-hydroxypropyl]-7-methoxy-5-methyl-4-oxo-4H-chromen-8-yl]-L-glucitol
Homo sapiens
-
pH 4.0, 25°C
0.0205
(6R)-2,6-anhydro-6-[7-methoxy-5-methyl-4-oxo-2-[(1E)-prop-1-en-1-yl]-4H-chromen-8-yl]-L-glucitol
Homo sapiens
-
pH 4.0, 25°C
0.034
(6R)-2-amino-3,6-dimethyl-6-(2-phenylethyl)-5,6-dihydropyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00008
(6R)-2-amino-6-[2-(3'-methoxybiphenyl-4-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.0016
(6R)-2-amino-6-[2-(biphenyl-4-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.00038
(6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.000011
(R)-3-(2-amino-6-(3-chloropyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylpropanamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000016
(R)-3-(2-amino-6-(3-methylpyridin-2-yl)quinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylpropanamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000015
(R)-N-(3-(3-amino-1-methyl-9-oxa-4-thia-2-azaspiro[5.5]undec-2-en-1-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000038
(R)-N-(3-(3-amino-5-methyl-9,9-dioxido-2,9-dithia-4-azaspiro[5.5]undec-3-en-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.000016
(R)-N-(3-(3-amino-9,9-difluoro-5-methyl-2-thia-4-azaspiro[5.5]undec-3-en-5-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000055
(R)-N-(3-(7-amino-2,2-difluoro-9-methyl-6-thia-8-azaspiro[3.5]non-7-en-9-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000009
(S)-3-(6,6-dimethyl-3,6-dihydro-2H-pyran-4-yl)-7-(2-fluoropyridin-3-yl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000007
(S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5H-spiro[chromeno[2,3-b]pyridine-5,4-oxazol]-2-amine
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000072
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.00002
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000049
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000046
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-chloropicolinamide
Homo sapiens
pH and temperature not specified in the publication
0.0000032
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-cyanopicolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000013
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-fluoropicolinamide
Homo sapiens
pH and temperature not specified in the publication
0.000011
(S)-N-(3-(2-amino-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0059
1-(2-chlorobenzyl)-4-(4-(dibenzo[b,d]furan-1-yl)benzyl)-1H-imidazol-2-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0056
1-(4-fluorobenzyl)-4-((30,50-dimethoxybiphenyl-4-yl)methyl)-1H-imidazol-2-amine
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.0447
1-[(3-benzoylamino-phenylcarbamoyl)-methyl]-3-carbamoyl-pyridiniumchloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.003
1-[(E)-[(4-methylquinazolin-2-yl)amino][(phenylcarbamoyl)amino]methylidene]-3-phenylurea
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.012
1-[[3-(4-chloro-phenylcarbamoyl)-phenylcarbamoyl]-methyl]-3-phenethylcarbamoyl-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.001
1-[[3-(4-chloro-phenylcarbamoyl)-phenylcarbamoyl]-methyl]-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.0037
1-[[3-(4-methoxy-phenylcarbamoyl)-phenylcarbamoyl]-methyl]-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.0022
1-[[3-(4-methyl-benzoylamino)-phenylcarbamoyl]-methyl]-3-phenethylcarbamoyl-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.013
1-[[3-(4-methyl-benzoylamino)-phenylcarbamoyl]-methyl]-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.04863
15,16-dihydrotanshinone
Homo sapiens
at pH 4.5 and 23°C
0.00035
2,3-dihydro-6-methylginkgetin
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00075
2,3-dihydroamentoflavone
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0386
2-((5-cyano-4-(2-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-(3-nitrophenyl)thiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0276
2-((5-cyano-4-(2-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-(4-nitrophenyl)thiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.015
2-((5-cyano-4-(3-ethoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-(4-nitrophenyl)thiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0046
2-((5-cyano-4-(3-ethoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-phenyl-1H-imidazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.015
2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-(3-(2-fluoropyridin-3-yl)phenyl)thiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0243
2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-(3-nitrophenyl)thiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0261
2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-(4-nitrophenyl)thiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0042
2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-phenyl-1H-imidazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0374
2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)eN-(4-phenylthiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0296
2-((5-cyano-6-oxo-4-(3-(trifluoromethoxy)phenyl)-1,6-dihydropyrimidin-2-yl)thio)eN-(4-phenylthiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0191
2-((5-cyano-6-oxo-4-(3-(trifluoromethyl)phenyl)-1,6-dihydropyrimidin-2-yl)thio)eN-(4-phenylthiazol-2-yl)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0606
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
Homo sapiens
-
prenylated flavone from the stem bark of Morus lhou, pH not specified in the publication, temperature not specified in the publication
0.00593
2-(3-(4-(3-(cyclohexylamino)-5-methylimidazo[1,2-a]pyridin-2-yl)phenoxy)propyl)isoindoline-1,3-dione
Homo sapiens
at pH 4.5 and 23°C
0.02942
2-(3-(4-(3-(cyclohexylamino)-6-methylimidazo[1,2-a]pyridin-2-yl)phenoxy)propyl)isoindoline-1,3-dione
Homo sapiens
at pH 4.5 and 23°C
0.00284
2-(3-(4-(3-(cyclohexylamino)-7-methylimidazo[1,2-a]pyridin-2-yl)phenoxy)propyl)isoindoline-1,3-dione
Homo sapiens
at pH 4.5 and 23°C
0.0149
2-(3-(4-(6-chloro-3-(cyclohexylamino)imidazo[1,2-a]pyridin-2-yl)-2-methoxyphenoxy)propyl) isoindoline-1,3-dione
Homo sapiens
at pH 4.5 and 23°C
0.000026
2-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-6-methoxy-1Hbenzo[d]imidazole
Homo sapiens
pH 4.5, 25°C
0.00516
2-amino-3-ethyl-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00077
2-amino-3-methyl-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00117
2-amino-3-methyl-5-(2-methylpyridin-4-yl)-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.0022
2-amino-3-methyl-5-(2-methylpyridin-4-yl)-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00048
2-amino-3-methyl-5-(pyridin-4-yl)-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00387
2-amino-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-5-[3-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00201
2-amino-3-methyl-5-phenyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00083
2-amino-3-methyl-5-phenyl-5-(tricyclo[3.3.1.13,7]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00613
2-amino-3-methyl-5-[2-(propan-2-yl)pyridin-4-yl]-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.036
2-amino-3-methyl-6-(naphthalen-2-ylmethyl)pyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.08719
2-amino-5,5-diphenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00054
2-amino-5-(1,3-benzodioxol-5-yl)-3-methyl-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.0005
2-amino-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-methyl-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00113
2-amino-5-(2,3-dihydro-1-benzofuran-5-yl)-3-methyl-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.0236
2-amino-5-(2,6-diethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.0241
2-amino-5-(2,6-dimethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00102
2-amino-5-(2-ethylpyridin-4-yl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00959
2-amino-5-(3,4-dimethoxyphenyl)-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00555
2-amino-5-(3-butoxyphenyl)-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00042
2-amino-5-(3-chlorophenyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00253
2-amino-5-(3-ethoxyphenyl)-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00629
2-amino-5-(3-methoxy-4-methylphenyl)-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00068
2-amino-5-(3-methoxyphenyl)-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00119
2-amino-5-(3-methoxyphenyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00184
2-amino-5-(4-chlorophenyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00433
2-amino-5-(4-ethyl-3-methoxyphenyl)-3-methyl-5-(tricyclo[3.3.1.1(3,7)]dec-1-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00096
2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-(6-methylbiphenyl-3-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00079
2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-[3-(pyridin-3-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00159
2-amino-5-(4-methoxy-3-methylphenyl)-3-methyl-5-[3-(pyrimidin-5-yl)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00172
2-amino-5-(4-methoxyphenyl)-3-methyl-5-phenyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00014
2-amino-5-(biphenyl-3-yl)-3-methyl-5-(pyridin-4-yl)-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.00417
2-amino-5-(biphenyl-3-yl)-5-(3,4-dimethoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00017
2-amino-5-(biphenyl-3-yl)-5-(3-butoxy-4-methoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00056
2-amino-5-(biphenyl-3-yl)-5-(3-chloro-4-methoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00096
2-amino-5-(biphenyl-3-yl)-5-(3-cyclopentyl-4-methoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.0006
2-amino-5-(biphenyl-3-yl)-5-(3-ethoxy-4-methoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.0002
2-amino-5-(biphenyl-3-yl)-5-(3-ethoxy-4-propoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00052
2-amino-5-(biphenyl-3-yl)-5-(3-fluoro-4-methoxyphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00078
2-amino-5-(biphenyl-3-yl)-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.0003
2-amino-5-(biphenyl-3-yl)-5-[3-(cyclopentyloxy)-4-methoxyphenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00184
2-amino-5-(biphenyl-3-yl)-5-[4-methoxy-3-(propan-2-yloxy)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.001
2-amino-5-(biphenyl-3-yl)-5-[4-methoxy-3-(trifluoromethyl)phenyl]-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00504
2-amino-5-[2-fluoro-3-(pyrimidin-5-yl)phenyl]-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00078
2-amino-5-[3-(2-fluoropyridin-3-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
0.00251
2-amino-5-[3-(2-methoxypyridin-3-yl)phenyl]-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00248
2-amino-5-[3-(6-fluoropyridin-3-yl)phenyl]-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00599
2-amino-5-[3-(6-methoxypyridin-3-yl)phenyl]-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00126
2-amino-5-[3-fluoro-5-(pyrimidin-5-yl)phenyl]-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00184
2-amino-5-[4-fluoro-3-(2-fluoropyridin-3-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00969
2-amino-5-[4-fluoro-3-(pyrimidin-5-yl)phenyl]-3-methyl-5-[4-(trifluoromethoxy)phenyl]-3,5-dihydro-4H-imidazol-4-one
Homo sapiens
pH and temperature not specified in the publication
0.00002 - 0.0028
2-amino-5-[4-fluoro-3-(pyrimidin-5-yl)phenyl]-5-(4-methoxy-3-methylphenyl)-3-methyl-3,5-dihydro-4H-imidazol-4-one
0.077
2-amino-6-(3a,7a-dihydro-1H-indol-6-ylmethyl)-3-methylpyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.13
2-amino-6-(3a,7a-dihydro-1H-indol-6-ylmethyl)pyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.22
2-amino-6-benzyl-3-methylpyrimidin-4(3H)-one
Homo sapiens
pH and temperature not specified in the publication
0.23
2-amino-8-(2-nitrophenyl)-9-phenyl-1,9-dihydro-6H-purin-6-one
Homo sapiens
pH and temperature not specified in the publication
0.21
2-amino-8-(4-bromophenyl)-9-phenyl-1,9-dihydro-6H-purin-6-one
Homo sapiens
pH and temperature not specified in the publication
0.0345
2-[(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)amino]-2-oxoethyl [(4,6-diphenylpyrimidin-2-yl)sulfanyl]acetate
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.02
2-[(3-cyano-4,6-diphenylpyridin-2-yl)sulfanyl]-N-(3-nitrophenyl)acetamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.021
2-[(4-methyl-5-[2-[(4-methylphenyl)amino]-2-oxoethyl]-4H-1,2,4-triazol-3-yl)sulfanyl]-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.0102
2-[(6-[[4,6-di(piperidin-1-yl)-1,3,5-triazin-2-yl]amino]-1,3-benzothiazol-2-yl)sulfanyl]-N-(2-fluorophenyl)acetamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.096
2-[[(1S,2S)-1-benzyl-2-hydroxy-3-oxo-3-[[3-(2H-tetrazol-5-yl)phenyl]amino]propyl]carbamoyl]-6-[[(4S)-4-phenyl-1,3-oxazolidin-3-yl]carbonyl]pyridin-4-yl methanesulfonate
Homo sapiens
i.e. KMI-1036, BACE1 inhibitors with a 5-membered ring at the P3 position and their BACE1 inhibitory activities summarized
0.001
2-[[2-amino-6-([2-(2-chlorophenyl)-5-[4-(pentyloxy)phenyl]-1H-pyrrol-1-yl]methyl)pyridin-3-yl]amino]ethanol
Homo sapiens
-
pH and temperature not specified in the publication
0.118
2-[[3-cyano-4-(4-fluorophenyl)-6-phenylpyridin-2-yl]sulfanyl]-N-(tricyclo[3.3.1.1(3,7)]dec-1-yl)acetamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.05
2-[[3-cyano-6-(4-fluorophenyl)-4-phenylpyridin-2-yl]sulfanyl]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.05
2-[[4-(4-chlorophenyl)-3-cyano-6-(4-methoxyphenyl)pyridin-2-yl]sulfanyl]-N-(naphthalen-2-yl)-N-phenylacetamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.1
2-[[4-benzyl-5-(1H-indol-3-ylmethyl)-4H-1,2,4-triazol-3-yl]sulfanyl]-1-(1H-indol-3-yl)ethanone
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.000004
3-(5-((7aR)-6-(5-fluoropyrimidin-2-yl)-2-imino-3-methyl-4-oxooctahydro-1H-pyrrolo[3,4-d]pyrimidin-7a-yl)thiophen-3-yl)benzonitrile
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.00005
3-(6-(2-acetylphenyl)-2-aminoquinolin-3-yl)-N-(3,3-dimethylbutyl)-2-methylpropanamide
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.1
3-(benzylsulfanyl)-6-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6,7-dihydro[1,2,4]triazino[5,6-d][3,1]benzoxazepine
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.000004
3-(butylsulfonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-N2-(3,3,3-trifluoropropanoyl)-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000022
3-(butylsulfonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-N2-(methoxyacetyl)-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
3-(butylsulfonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-N2-(pyridin-3-ylacetyl)-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000011
3-(butylsulfonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-N2-(pyridin-4-ylacetyl)-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000008
3-(butylsulfonyl)-N2-(3-cyanopropanoyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00001
3-(butylsulfonyl)-N2-(cyclopropylcarbonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00367
3-(cyclohexylsulfonyl)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000484
3-(dibutylsulfamoyl)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00109
3-(dipropylsulfamoyl)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000596
3-(heptan-4-ylsulfonyl)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0302
3-carbamoyl-1-[[3-(4-chloro-phenylcarbamoyl)-phenylcarbamoyl]-methyl]-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.0019
3-carbamoyl-1-[[3-(4-methoxy-phenylcarbamoyl)-phenylcarbamoyl]-methyl]-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.000005
3-chloro-N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.004
3-phenethylcarbamoyl-1-[(3-p-tolylcarbamoyl-phenylcarbamoyl)-methyl]-pyridinium chloride
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 37°C
0.0000012 - 0.0012
3-[(2H-tetrazol-5-ylcarbonyl)amino]-L-alanyl-L-valyl-N-((1S,2R)-1-benzyl-3-[(3,5-di-2H-tetrazol-5-ylphenyl)amino]-2-hydroxy-3-oxopropyl)-L-leucinamide
0.0000039 - 0.0039
3-[(2H-tetrazol-5-ylcarbonyl)amino]-L-alanyl-L-valyl-N-((1S,2R)-1-benzyl-3-[(3,5-dicarboxyphenyl)amino]-2-hydroxy-3-oxopropyl)-L-leucinamide
0.0000082 - 0.0082
3-[(2H-tetrazol-5-ylcarbonyl)amino]-L-alanyl-L-valyl-N-((1S,2R)-1-benzyl-3-[(3-carboxyphenyl)amino]-2-hydroxy-3-oxopropyl)-L-leucinamide
0.0000048 - 0.0048
3-[(2H-tetrazol-5-ylcarbonyl)amino]-L-alanyl-L-valyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-oxo-3-([3-(2H-tetrazol-5-yl)phenyl]amino)propyl]-L-leucinamide
0.0000066
3-[(2H-tetrazol-5-ylcarbonyl)amino]-L-alanyl-L-valyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-oxo-3-([3-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino)propyl]-L-leucinamide
Homo sapiens
-
0.0002 mM, 94.2% inhibition, IC50: 6.6 nM
0.0000064
3-[(2H-tetrazol-5-ylcarbonyl)amino]-L-alanyl-L-valyl-N-[(1S,2R)-1-benzyl-2-hydroxy-3-oxo-3-([3-(5-thioxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino)propyl]-L-leucinamide
Homo sapiens
-
0.0002 mM, 97.2% inhibition, IC50: 6.4 nM
0.0000048
3-[(2H-tetrazol-5-ylcarbonyl)amino]alanyl-L-valyl-N-(1-benzyl-2-hydroxy-3-oxo-3-[[3-(2H-tetrazol-5-yl)phenyl]amino]propyl)leucinamide
Homo sapiens
-
-
0.0000012
3-[(2H-tetrazol-5-ylcarbonyl)amino]alanyl-L-valyl-N-[1-benzyl-3-[(3,5-di-2H-tetrazol-5-ylphenyl)amino]-2-hydroxy-3-oxopropyl]leucinamide
Homo sapiens
-
-
0.00012
3-[5-[(1R)-1-amino-1-methyl-2-phenylethyl]-1,3,4-oxadiazol-2-yl]-N-[1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide
Homo sapiens
-
-
0.0000056
3-[[(5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)carbonyl]amino]alanyl-L-valyl-N-[(1S)-1-benzyl-2-hydroxy-3-oxo-3-[[3-(2H-tetrazol-5-yl)phenyl]amino]propyl]phenylalaninamide
Homo sapiens
-
-
0.00047
3-[[2-amino-6-([2-(2-chlorophenyl)-5-[4-(pentyloxy)phenyl]-1H-pyrrol-1-yl]methyl)pyridin-3-yl]amino]propan-1-ol
Homo sapiens
-
pH and temperature not specified in the publication
0.0071
4-(4-[1-[(6-aminopyridin-2-yl)methyl]-5-(2-chlorophenyl)-1H-pyrrol-2-yl]phenoxy)butanenitrile
Homo sapiens
-
pH and temperature not specified in the publication
0.00011
4-(cyclohexylamino)-1-(4-fluorobenzyl)-8-[(2'-methylbiphenyl-4-yl)methyl]-1,3,8-triazaspiro[4.5]dec-3-en-2-one
Homo sapiens
-
-
0.00795
4-(dipropylsulfamoyl)-N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.09
4-bromo-N-[(4-bromophenyl)sulfonyl]-N-[1-(3,4-dichlorobenzyl)-1H-pyrazol-4-yl]benzenesulfonamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.0018
4-[1-(4-methoxyphenyl)-2-[4-(trifluoromethyl)phenyl]ethyl]-1-methyl-1H-imidazol-2-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00047
4-[2-(2-methoxy-5-nitrophenyl)-1-(4-methoxyphenyl)ethyl]-1-methyl-1H-imidazol-2-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.000063
4-[4-fluoro-5-methoxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.0032
4-[5-methoxy-2-(2-methoxy-5-nitrophenyl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.00035
4-[5-methoxy-2-[4-(trifluoromethyl)phenyl]-2,3-dihydro-1H-inden-1-yl]-1-methyl-1H-imidazol-2-amine
Homo sapiens
-
pH and temperature not specified in the publication
0.008
4-[8-benzyl-4-(cyclohexylamino)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-1-yl]benzamide
Homo sapiens
-
-
4
4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-2-amine
Homo sapiens
pH and temperature not specified in the publication
0.02
5-[(E)-benzylideneamino]-6-methoxy-N4-phenylpyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.012
5-[(E)-[(2,4,-diclorophenyl)methylidene]amino]-6-methoxy-N4-phenylpyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.075
5-[(E)-[(2-chlorophenyl)methylidene]amino]-6-methoxy-N4-phenylpyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00232
5-[2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]biphenyl-2-carbonitrile
Homo sapiens
pH and temperature not specified in the publication
0.00055
5-[2-amino-4-(biphenyl-3-yl)-1-methyl-5-oxo-4,5-dihydro-1H-imidazol-4-yl]-2-methoxybenzonitrile
Homo sapiens
pH and temperature not specified in the publication
0.64
6,7-furano-5,8a-dimethoxy hydrocoumaric acid methyl ester
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.1856
6,7-furano-5-prenyloxy hydrocoumaric acid
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.0305
6,7-furano-5-prenyloxy hydrocoumaric acid methyl ester
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.2033
6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.0162
6,7-furano-8a-methoxy-5-prenyloxy hydrocoumaric acid methyl ester
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.0018
6-fluoro-2-(3-(7-fluoroimidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo[d]imidazole
Homo sapiens
pH 4.5, 25°C
0.000035
6-fluoro-2-(3-(imidazo[1,2-a]pyridin-2-yl)phenyl)-1H-benzo-[d]imidazole
Homo sapiens
pH 4.5, 25°C
0.044
6-methoxy-5-[(E)-(4-methylbenzylidene)amino]-N4-phenylpyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.05
6-methoxy-5-[(E)-[(2-nitrophenyl)methylidene]amino]-N4-phenylpyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.038
6-methoxy-N4-phenyl-5-[(E)-[4-(trifluoromethyl)benzylidene]amino]pyrimidine-2,4-diamine
Homo sapiens
pH and temperature not specified in the publication
0.00859
7-phloroethol
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.0383
8,8-diphenyl-2,3,4,8-tetrahydroimidazo[1,5-a]pyrimidin-6-amine
Homo sapiens
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4
0.0046
8-(biphenyl-4-ylmethyl)-4-(cyclohexylamino)-1-(4-fluorobenzyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one
Homo sapiens
-
-
0.011
8-benzyl-4-(cyclohexylamino)-1-(3-fluorophenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one
Homo sapiens
-
-
0.039
aloeresin D
Rattus norvegicus
-
-
0.0269
benzyl 1-(3-acetoxypropyl)-5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0391
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-(dimethylamino)-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0282
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-(isopropyl(methyl)amino)-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0155
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-ethoxy-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.009
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0161
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-2,4-dimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0152
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-methoxy-2-oxoethyl)-2,4,6-trimethyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0284
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethyl-1-(2-morpholino-2-oxoethyl)-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0149
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethyl-1-(methylsulfonyl)-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0214
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-1-(methylsulfonyl)-4-phenyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0081
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-1-(methylsulfonyl)-4-propyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0095
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-4-ethyl-2,6-dimethyl-1-(methylsulfonyl)-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.011
benzyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-4-isopropyl-2,6-dimethyl-1-(methylsulfonyl)-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
benzyl [(2S)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0000098 - 0.0000124
beta-secretase inhibitor IV
0.0205
C-2'-decoumaroyl-aloeresin G
Rattus norvegicus
-
-
0.2
caffeic acid
Homo sapiens
at pH 4.5 and 23°C
0.03995
cryptotanshinone
Homo sapiens
at pH 4.5 and 23°C
0.03034
dehydrodanshenol A
Homo sapiens
at pH 4.5 and 23°C
0.01153
deoxyneocryptotanshinone
Homo sapiens
at pH 4.5 and 23°C
0.00221
dieckol
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.00535
dioxinodehydroeckol
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.0122
eckol
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.000603 - 0.000651
EVD(statine)VAEF
0.00045 - 0.000452
EVE(statine)VAEF
0.004673 - 0.005319
EVG(statine)VAEF
0.000251 - 0.000265
EVL(statine)VAEF
0.0000014 - 0.0000016
EVNLAAEF
0.0066 - 0.00754
EVW(statine)VAEF
0.000118 - 0.000126
EVY(statine)VAEF
0.2
ferruginol
Homo sapiens
at pH 4.5 and 23°C
0.10306
grandifolia F
Homo sapiens
at pH 4.5 and 23°C
-
0.001
GRL-8234
Homo sapiens
i.e. inhibitor 24, in Chinese hamster ovary cells
0.0918
imperatorin
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.2442
isoimperatorin
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.0312
isopropyl 2-(3-((2S,3R)-3-hydroxy-4-(3-methoxyphenylamino)-1-phenylbutan-2-ylcarbamoyl)-5-((R)-1-phenylethylcarbamoyl)-4-propylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0328
isopropyl 2-(3-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-4-methyl-5-((R)-1-phenylethylcarbamoyl)pyridin-1(4H)-yl) acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0296
isopropyl 2-(3-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-5-((R)-1-phenylethylcarbamoyl)-4-propylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0232
isopropyl 2-(3-acetyl-5-((2S,3R)-3-hydroxy-4-(3-methoxybenzylamino)-1-phenyl butan-2-ylcarbamoyl)-2,6-dimethyl-4-propylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0261
isopropyl 2-(3-acetyl-5-((2S,3R)-3-hydroxy-4-(3-methoxybenzylamino)-1-phenylbutan-2-ylcarbamoyl)-2,4-dimethylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0266
isopropyl 2-(3-acetyl-5-((2S,3R)-3-hydroxy-4-(3-methoxyphenylamino)-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-4-propylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0264
isopropyl 2-(3-acetyl-5-((2S,3R)-4-(3-fluorophenylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0293
isopropyl 2-(3-acetyl-5-((2S,3R)-4-(3-fluorophenylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4-dimethylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0271
isopropyl 2-(3-acetyl-5-((2S,3R)-4-(3-fluorophenylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-4-propylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0293
isopropyl 2-(3-acetyl-5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,4,6-trimethylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0331
isopropyl 2-(3-acetyl-5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-2,6-dimethyl-4-propylpyridin-1(4H)-yl)acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.041
KTEETSEVN(statine)VAEF
Homo sapiens
i.e. P10-P40 StatVal, dose-dependent inhibition shown, cleavage determined by fluoresence assay
0.0034
kuwanon
Homo sapiens
-
prenylated flavone from the stem bark of Morus lhou, pH not specified in the publication, temperature not specified in the publication
0.0053
kuwanon A
Homo sapiens
-
pH not specified in the publication, temperature not specified in the publication
0.000012
L-alpha-glutamyl-L-leucyl-N-[(2S,5S,8S,14R)-2-carboxy-5-(carboxymethoxy)-13-hydroxy-11,16-dimethyl-13-oxido-4,7,10-trioxo-1-phenyl-8-(propan-2-yl)-3,6,9-triaza-13-lambda5-phosphaheptadecan-14-yl]-L-alpha-asparagine
Homo sapiens
-
pH and temperature not specified in the publication
0.0005
luteolin
Perilla frutescens
-
non-competitive inhibition
0.0002
Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-(statine)-Val-Ala-Glu-Phe-OH
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.00012
Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.00014
Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-[statine(3S,4S)]-Val-Ala-Glu-Phe-OH
0.03035
magnesium lithospermate
Homo sapiens
at pH 4.5 and 23°C
0.0356
methyl tanshinonate
Homo sapiens
at pH 4.5 and 23°C
0.000003
methyl [(2S)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.0594
morusin
Homo sapiens
-
prenylated flavone from the stem bark of Morus lhou, pH not specified in the publication, temperature not specified in the publication
0.000005
N'-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-iodobenzyl)amino]butan-2-yl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00031
N'-[(2S,3R)-3-hydroxy-4-[(3-iodobenzyl)amino]-1-phenylbutan-2-yl]-N,N-dipropylbenzene-1,3-dicarboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0005
N'-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-N,N-dipropylbenzene-1,3-dicarboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0122
N,N'-bis(3-cyano-4,5,6,7,8,9-hexahydrocycloocta[b]thiophen-2-yl)-2,2,3,3,4,4,5,5-octafluorohexanediamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.000015 - 0.00046
N-((1S,2R)-1-benzyl-3-cyclopropylamino-2-hydroxy-propyl)-5-(methanesulfonyl-methyl-amino)-N'-((R)-1-phenyl-ethyl)-isophthalamide
0.0361
N-((4aRS,6RS,8aSR)-2-amino-5,6,7,8-tetrahydro-4H-4a,8a-(methanooxymethano)benzo[d][1,3]thiazin-6-yl)-3-chlorobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.00183
N-(2-amino-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-6-yl)-3-chlorobenzamide
Homo sapiens
pH and temperature not specified in the publication
0.024
N-(2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl)methanesulfonamide
Homo sapiens
-
-
0.000076
N-(2-methylpropyl)-N2-([17-[(methylsulfonyl)(propyl)amino]-2-oxo-3-azatricyclo[13.3.1.16,10]icosa-1(19),6(20),7,9,15,17-hexaen-4-yl]methyl)-L-norleucinamide
Homo sapiens
-
-
0.0000083
N-(3-((4R,5R)-2-amino-5-methoxy-4-methyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000032
N-(3-((4S,5R)-2-amino-4-methyl-5-(tetrahydro-2H-pyran-4-yl)-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000017
N-(3-((4S,5R)-2-amino-4-methyl-5-phenyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0000033
N-(3-((4S,5S)-2-amino-4-methyl-5-phenyl-5,6-dihydro-4H-1,3-thiazin-4-yl)-4-fluorophenyl)-5-(fluoromethoxy)pyrazine-2-carboxamide
Homo sapiens
pH and temperature not specified in the publication
0.0175
N-(4-(3-bromophenyl)thiazol-2-yl)-2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0032
N-(4-(4-amino-3,5-dichlorophenyl)-1H-imidazol-2-yl)-2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0135
N-(4-(4-amino-3,5-dichlorophenyl)thiazol-2-yl)-2-((5-cyano-4-(3-ethoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0077
N-(4-(4-amino-3,5-dichlorophenyl)thiazol-2-yl)-2-((5-cyano-4-(3-methoxyphenyl)-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0134
N-(4-(4-amino-3,5-dichlorophenyl)thiazol-2-yl)-2-((5-cyano-6-oxo-4-(3-(trifluoromethyl)phenyl)-1,6-dihydropyrimidin-2-yl)thio)acetamide
Homo sapiens
at pH 4.5 and 25°C
0.0028
N-(4-([4-(cyclohexylamino)-1-(3-fluorophenyl)-2-oxo-1,3,8-triazaspiro[4.5]dec-3-en-8-yl]methyl)phenyl)acetamide
Homo sapiens
-
-
0.015
N-(5-([6-(4-(N,N-dimethyl)aminophenyl)pyrimidin-4-yl]amino)-2-methylphenyl)-N-methylmethanesulfonamide
Homo sapiens
-
-
0.021
N-(5-[[6-(2,3-dihydro-1,4-benzodioxin-6-yl)pyrimidin-4-yl]amino]-2-methylphenyl)-N-methylmethanesulfonamide
Homo sapiens
-
-
0.00231
N-(tert-butoxycarbonyl)-L-leucyl-N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000027
N-acetyl-beta-alanyl-3-(butylsulfonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-D-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.004
N-acetyl-L-alanyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-methioninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00012
N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-alaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000053
N-acetyl-L-leucyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-methioninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00037
N-acetyl-L-valyl-N-[(4S,5S,7R)-8-(butylamino)-5-hydroxy-2,7-dimethyl-8-oxooctan-4-yl]-L-methioninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0116
N-benzyloxycarbonyl-Val-Leu-leucinal
Rattus norvegicus
-
-
0.000005
N-[(1R,2S)-1-benzyl-2-hydroxy-3-[[3-(trifluoromethyl)benzyl]amino]propyl]-3-(1,1-dioxido-1,2-thiazinan-2-yl)-5-(ethylamino)-2-fluorobenzamide
Homo sapiens
-
-
0.000002
N-[(1S)-1-[(butylsulfonyl)methyl]-2-([1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl]amino)-2-oxoethyl]benzamide
Homo sapiens
-
-
0.36
N-[(1S,2S)-1-benzyl-2-hydroxy-3-oxo-3-[[3-(2H-tetrazol-5-yl)phenyl]amino]propyl]-4-oxo-6-[[(4S)-4-phenyl-1,3-oxazolidin-3-yl]carbonyl]-1,4-dihydropyridine-2-carboxamide
Homo sapiens
i.e. KMI-1030, BACE1 inhibitors with a 5-membered ring at the P3 position and their BACE1 inhibitory activities summarized
0.05
N-[(1S,2S)-1-benzyl-2-hydroxy-3-oxo-3-[[3-(2H-tetrazol-5-yl)phenyl]amino]propyl]-4-oxo-6-[[(4S)-4-phenyl-1,3-oxazolidin-3-yl]carbonyl]-4H-pyran-2-carboxamide
Homo sapiens
i.e. KMI-1027, BACE1 inhibitors with a 5-membered ring at the P3 position and their BACE1 inhibitory activities summarized
0.14
N-[(1S,2S)-1-benzyl-2-hydroxy-3-oxo-3-[[3-(2H-tetrazol-5-yl)phenyl]amino]propyl]-6-[[(4S)-4-phenyl-1,3-oxazolidin-3-yl]carbonyl]pyridine-2-carboxamide
Homo sapiens
i.e. KMI-1023, BACE1 inhibitors with a 5-membered ring at the P3 position and their BACE1 inhibitory activities summarized
0.00011
N-[(1Z)-amino(butylamino)methylidene]-2-[2-(2-chlorophenyl)-5-(4-propoxyphenyl)-1H-pyrrol-1-yl]acetamide
Homo sapiens
-
-
0.000015
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]-2-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]-3-hydroxybenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000053
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]-4-(trifluoromethyl)benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]-4-methoxybenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]-4-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]benzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000001
N-[(2R)-1-([1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]pyridine-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000049
N-[(2R)-2-amino-1-benzyl-3-fluoropropyl]-2-[[(2-methylcyclopropyl)methyl]amino]-6-[methyl[(1-methylethyl)sulfonyl]amino]pyridine-4-carboxamide
Homo sapiens
-
-
0.00467
N-[(2S)-1-([(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]amino)-1-oxo-3-phenylpropan-2-yl]naphthalene-1-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
N-[(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]-1H-imidazole-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000005
N-[(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]-4-hydroxypyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
N-[(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]-5-methyl-1H-pyrazole-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000004
N-[(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]pyrazine-2-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-[(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]pyridine-3-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000005
N-[(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]pyridine-4-carboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0041
N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-[(3-iodobenzyl)amino]butan-2-yl]-3-methylbenzamide
Homo sapiens
-
pH and temperature not specified in the publication
0.005214
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-3-(phenylsulfonyl)propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.003785
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-3-(piperidin-1-ylsulfonyl)propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.005015
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-3-[(3-methylbutyl)sulfamoyl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.005614
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-3-[(3-methylbutyl)sulfonyl]propanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.004131
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-4-(phenylsulfonyl)butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.006461
N-[(2S,3R)-3-hydroxy-4-[(3-methoxybenzyl)amino]-1-phenylbutan-2-yl]-4-(piperidin-1-ylsulfonyl)butanamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-[(4S)-4-[(1R)-1-hydroxy-2-([1-[3-(propan-2-yl)phenyl]cyclopropyl]amino)ethyl]-2-oxo-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-19-yl]-N-methylpropane-1-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000001
N-[(4S)-4-[(1R)-1-hydroxy-2-[[3-(propan-2-yl)benzyl]amino]ethyl]-2-oxo-11-oxa-3,16-diazatricyclo[15.3.1.1(6,10)]docosa-1(21),6(22),7,9,17,19-hexaen-19-yl]-N-methylpropane-1-sulfonamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000616
N-[(4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]methylcarbamoyl-5-hydroxy-2-methyloct-4-yl]-N'-[(R)-1-(4-fluorophenyl)ethyl-5-methyl(methylsulfonyl)amino]isophthalamide
Homo sapiens
-
pH 4.0
0.00264
N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-4-nitro-Nalpha-(4-nitrobenzoyl)-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00379
N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-4-nitro-Nalpha-[(2Z)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.01573
N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-Nalpha-(4-nitrobenzoyl)-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.01954
N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-Nalpha-[(2Z)-3-[4-(trifluoromethyl)phenyl]prop-2-enoyl]-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000002
N-[(5R)-5-amino-5-methyl-4,16-dioxo-14-phenyl-3-oxa-15-azatricyclo[15.3.1.17,11]docosa-1(21),7(22),8,10,17,19-hexaen-19-yl]-N-methylmethanesulfonamide
Homo sapiens
-
-
0.0286
N-[(Z)-[(4,6-dimethylpyrimidin-2-yl)amino][(3-nitrophenyl)amino]methylidene]-10H-phenothiazine-10-carboxamide
Homo sapiens
-
in 50 mM Tris (pH 7.5), at 25°C
0.000005
N-[1-(3,5-difluorobenzyl)-2-hydroxy-3-[(3-iodobenzyl)amino]propyl]-5-methyl-N'-propylbenzene-1,3-dicarboxamide
Homo sapiens
-
-
0.00012 - 0.0028
N-[2-(3,4-dimethoxyphenyl)ethyl]-2-[(6-[[4,6-di(piperidin-1-yl)-1,3,5-triazin-2-yl]amino]-1,3-benzothiazol-2-yl)sulfanyl]acetamide
0.0000025
N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-3,4-dichloro-N-phenylbenzamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000038
N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-4-methoxy-N-phenylbenzamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.0000048
N-[3-(9H-carbazol-9-yl)-2-hydroxypropyl]-N-(2-phenylethyl)benzamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.1
N-[5-(2,3-dichlorobenzyl)-1,3-thiazol-2-yl]-4-([[4-phenyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)benzamide
Homo sapiens
-
IC50 above 0.1 mM, in 50 mM Tris (pH 7.5), at 25°C
0.00023
N1-((2S,3S)-4-(4-(diethylcarbamoyl)-1H-pyrazol-1-yl)-3-hydroxy-1-phenylbutan-2-yl)-N3-((R)-1-(4-fluorophenyl)ethyl)-5-(N-methylmethylsulfonamido)isophthalamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000036
N1-((R)-1-(4-fluorophenyl)ethyl)-N3-((2S,3S)-3-hydroxy-4-(4-((R)-1-hydroxy ethyl)-1H-1,2,3-triazol-1-yl)-1-phenylbutan-2-yl)-5-(N-methylmethylsulfonamido)isophthalamide
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000004 - 0.000013
N2-acetyl-3-(butylsulfonyl)-N-[(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]-D-alaninamide
0.0161
N3-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-2,4,6-trimethyl-1-(methylsulfonyl)-N5-((R)-1-phenylethyl)-1,4-dihydropyridine-3,5-dicarboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.0162
N3-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl)-4-ethyl-2,6-dimethyl-1-(methylsulfonyl)-N5-((R)-1-phenylethyl)-1,4-dihydropyridine-3,5-dicarboxamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00807
Nalpha-(1,3-benzodioxol-5-ylcarbonyl)-N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00424
Nalpha-(2,4-dichlorobenzoyl)-N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-4-nitro-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00381
Nalpha-(3,4-dimethoxybenzoyl)-N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-4-nitro-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.00693
Nalpha-benzoyl-N-[(4S,5S,7R)-5-hydroxy-2,7-dimethyl-8-[(2-methylpropyl)amino]-8-oxooctan-4-yl]-L-phenylalaninamide
Homo sapiens
-
pH and temperature not specified in the publication
0.000017
NB-216
Homo sapiens
-
pH and temperature not specified in the publication
0.000006
OM00-3
Homo sapiens
-
pH and temperature not specified in the publication
0.0000024 - 0.0007
OM99-2
0.02119 - 0.482
pepstatin A
0.00213
phlorofurofucoeckol-A
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.03647
phloroglucinol
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
0.000004
pyridin-3-ylmethyl [(2S)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.000003
pyridin-4-ylmethyl [(2S)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-3-(heptan-4-ylsulfonyl)-1-oxopropan-2-yl]carbamate
Homo sapiens
-
pH and temperature not specified in the publication
0.01049 - 0.01082
quercetin
0.0021 - 0.02977
rosmarinic acid
0.000015
S-(tetrahydrofuran-3-yl) [(2S)-3-(butylsulfonyl)-1-([(2S,3R)-1-(3,5-difluorophenyl)-4-[(3-ethylbenzyl)amino]-3-hydroxybutan-2-yl]amino)-1-oxopropan-2-yl]carbamothioate
Homo sapiens
-
pH and temperature not specified in the publication
0.01301
salvianolic acid A
Homo sapiens
at pH 4.5 and 23°C
0.00918
salvianolic acid C
Homo sapiens
at pH 4.5 and 23°C
0.09822
tanshinol B
Homo sapiens
at pH 4.5 and 23°C
0.03402
tanshinonal
Homo sapiens
at pH 4.5 and 23°C
0.02846
tanshinone I
Homo sapiens
at pH 4.5 and 23°C
0.09186
tanshinone IIA
Homo sapiens
at pH 4.5 and 23°C
0.2
tanshinone IIB
Homo sapiens
at pH 4.5 and 23°C
0.0304
tert-butyl 5-((2S,3R)-3-hydroxy-4-(3-methoxyphenylamino)-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-4-propyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0319
tert-butyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-4-methyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.0246
tert-butyl 5-((2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-ylcarbamoyl)-1-(2-isopropoxy-2-oxoethyl)-4-propyl-1,4-dihydropyridine-3-carboxylate
Homo sapiens
-
pH and temperature not specified in the publication
0.01168
triphloroethol A
Homo sapiens
-
in 50 mM sodium acetate, pH 4.5, at 25°C
additional information
additional information
Homo sapiens
beta-secretase inhibitors with a hydroxymethylcarbonyl (HMC) isostere used as a substrate transition-state mimic, potent BACE1 inhibitory activities of about 0.0012 mM IC50 shown, BACE1 inhibitors with a 5-membered ring at the P3 position and their BACE1 inhibitory activities summarized
-