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3.4.23.46: memapsin 2

This is an abbreviated version!
For detailed information about memapsin 2, go to the full flat file.

Word Map on EC 3.4.23.46

Reaction

broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =

Synonyms

alpha-secretase, amyloid precursor protein secretase, APP secretase, Asec-1A, aspartic protease BACE, aspartic protease BACE1, Aspartic proteinase, aspartic proteinase BACE1, BACE, BACE 1, BACE I, BACE-1, BACE-2, BACE1, BACE1/beta-secretase, BACE2, beta protein amyloidogenase, beta secretase, beta-amyloid cleaving enzyme, beta-amyloid cleaving enzyme 1, beta-amyloid cleaving enzyme-1, beta-amyloid precursor protein cleavage enzyme 1, beta-amyloid precursor protein cleaving enzyme, beta-amyloid protein precursor secretase, beta-amyloid-cleaving enzyme, beta-amyloid-converting enzyme-1, beta-APP cleaving enzyme 1, beta-secretase, beta-secretase enzyme 1, beta-secretase-1, beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1), beta-site amyloid cleaving enzyme, beta-site amyloid precursor protein cleavage enzyme, beta-site amyloid precursor protein cleaving enzyme, beta-site amyloid precursor protein cleaving enzyme 1, beta-site amyloid precursor protein cleaving enzyme-1, beta-site amyloid precursor protein enzyme 1, beta-site amyloid precursor protein-cleaving enzyme, beta-site amyloid precursor protein-cleaving enzyme 1, beta-site APP (amyloid precursor protein) cleaving enzyme, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 1, beta-site APP cleaving enzyme-1, beta-site APP-cleaving enzyme 1, D-aspartyl-beta-amyloid secretase, gamma-secretase, memapsin 1, memapsin 2, memapsin2, membrane-bound aspartic protease, NACE1, presenilin 1, presenilin-1, presenilin-2, protease Asp2, proteinase BACE1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.46 memapsin 2

Expression

Expression on EC 3.4.23.46 - memapsin 2

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
administration of icariin (30, 60 and 120 mg/kg) significantly reduces the contents of Abeta1-40 and the mRNA levels of beta-secretase in the hippocampus
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amyloid beta augments protein levels of BACE-1 through oxidative stress, administration of amyloid beta 1-42 for 48 h significantly increases BACE-1 expression levels, simultaneous administration of ibuprofen or indomethacin (0.01 mM) significantly suppresses amyloid beta 1-42-induced BACE-1 up-regulation (0.005 mM, 48 h) in a concentration-dependent manner
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BACE-1 activity correlates closely with age in controls and is significantly higher in Alzheimer's disease. BACE-1 activity correlates with total insoluble Abeta
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BACE-1 activity correlates inversely with total soluble and oligomeric Abeta1-42
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BACE1 activity is substantially increased in the superior frontal gyrus in Alzheimer’s disease cases
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BACE1 levels in 5XFAD mice are significantly increased up to 200% of those found in wild type mice
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depletion of mu4 by RNAi does not alter the distribution of beta-secretase (BACE1)
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endogenous testosterone, independent of estrogen, downregulates BACE1 activities at transcriptional level. Heterozygous transgenic APP23/aromatase male mice exhibit decreased BACE1 protein expression and activity compared with control mice at age of 12 and 18 months
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exacerbation of poststroke dementia by type 2 diabetes is associated with synergistic increases of beta-secretase activation, high fat diet-streptozotocin treatment increases the stroke-induced elevation of BACE1 expression and activity in the rat hippocampus. Middle cerebral artery occlusion-high fat diet-streptozotocin rats demonstrate an increase in BACE1 mRNA to 239.6% 24 h after ischemic operation compared with sham-normal pellet diet rats
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induced expression of PS1 represents induction of gamma-secretase activity in injured white matter axons
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injection of 0.01 mg beta-amyloid peptide segment 25-35 induces expression of beta-secretase in rat hippocampus
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mRNAand activity level of BACE1 in the cortex and hippocampus remain unchanged by dietary quercetin supplementation. Supplementing primary cortical neurons with 0.00001, 0.0001 and 0.001 mM quercetin does not result in any significant change in mRNA level of BACE
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no correlation is observed between BACE-1 activity and NEP protein level
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oligemia/mild hypoperfusion produces a long lasting effect on Alzheimer’s disease related proteins, increasing amyloid-beta levels via enhanced BACE1 expression
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peptidylprolyl isomerase (cyclophilin)-like 2 positively regulates BACE1 expression
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repression of presenilin-1 transcription by JNk inhibitor SP600125 inhibits gamma-secretase mediated processing of amyloid precursor protein
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reticulon 3 is a negative modulator of BACE1 (beta-secretase) proteolytic activity
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the loss of Niemann-Pick type C1 affects beta-amyloid generation by increasing beta-secretase cleavage
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the mRNA level of BACE1 is not regulated by lovestatin
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thiamine deficiency promotes maturation of BACE1 and increases beta-secretase activity after 3 days
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treatment with chitosan oligosaccharides (0.001-5 mg/ml) results in a dramatic reduction in enzyme mRNA level and activity