3.4.23.41: yapsin 1
This is an abbreviated version!
For detailed information about yapsin 1, go to the full flat file.
Word Map on EC 3.4.23.41
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3.4.23.41
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prohormone
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granules
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monobasic
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propeptide
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aspartyl
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pituitary
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cholecystokinin
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non-anchored
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tetrabasic
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parathyroid
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pepstatin
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endoglycosidase
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acth
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zymogen
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pheromone
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dibasic
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pro-opiomelanocortin
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proproteins
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residue-specific
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prohormone-processing
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synthesis
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medicine
- 3.4.23.41
-
prohormone
- granules
-
monobasic
- propeptide
-
aspartyl
-
pituitary
- cholecystokinin
-
non-anchored
-
tetrabasic
- parathyroid
- pepstatin
-
endoglycosidase
- acth
- zymogen
- pheromone
-
dibasic
- pro-opiomelanocortin
- proproteins
-
residue-specific
-
prohormone-processing
- synthesis
- medicine
Reaction
hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions =
Synonyms
aspartic protease yapsin I, aspartic proteinase 3, Kex2, More, opsA, Yap3 gene product, yeast aspartic protease, yeast aspartic protease 3, YPS1, YPS7
ECTree
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Substrates Products
Substrates Products on EC 3.4.23.41 - yapsin 1
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REACTION DIAGRAM
aminobenzoyl-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH + H2O
?
-
-
?
anglerfish pro-somatostatin I
(Lys-) anglerfish somatostatin 14
-
-
-
?
anglerfish pro-somatostatin II
anglerfish somatostatin 28
-
-
-
?
human adrenocorticotropic hormone 1-39
human adrenocorticotropic hormone 1-15 + corticotropin-like intermediate lobe peptide 16-39
pre-elafin + H2O
elafin + ?
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cleavage occurs C-terminal to a subset of single Lys residues
-
?
pro-alpha-mating factor + H2O
alpha-mating factor + pro-sequence of alpha-mating factor
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processing
-
-
?
pro-somatostatin II + H2O
somatostatin-28 + pro-sequence of somatostatin-28
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processing, cleavage after a single Arg residue
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-
?
proopiomelanocortin
adrenocorticotropic hormone 1-39 + adrenocorticotropic hormone 1-14
-
-
-
?
human adrenocorticotropic hormone 1-15 + corticotropin-like intermediate lobe peptide 16-39
-
-
-
?
human adrenocorticotropic hormone 1-39
human adrenocorticotropic hormone 1-15 + corticotropin-like intermediate lobe peptide 16-39
-
-
-
?
?
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proteolysis generates three fragments, one cleavage occurs at dibasic site R25/K26
-
?
human parathyroid hormone + H2O
?
-
proteolysis generates two fragments, cleavage occurs at dibasic site R25/K26
-
?
?
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the enzyme cleaves behind the sequence Lys27-Asp28-Lys29-Arg30 of protein Scw4
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-
?
protein Scw4 + H2O
?
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the enzyme cleaves behind the sequence Lys27-Asp28-Lys29-Arg30 of protein Scw4
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-
?
synthetic proalbumin
RGVFRR + DEAKSEVAW
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substrate is representing the propeptide cleavage site RGVFRRDAHKSEVAW
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?
additional information
?
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the enzyme is involved in proteolysis of the secretory pathway, regulatory parameters, overview
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-
?
additional information
?
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the enzyme is required for cell wall integrity protecting the cells from lysis during environmental stress and morphogenesis, overview
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-
?
additional information
?
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the enzyme shows a preference for substrates with basic residues downstream as well as upstream of the scissile bond
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-
?
additional information
?
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the enzyme splits peptide bonds specifically after two basic amino acids, often preceded by two charged amino acids
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-
?
additional information
?
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-
the enzyme splits peptide bonds specifically after two basic amino acids, often preceded by two charged amino acids
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-
?