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3.4.23.41: yapsin 1

This is an abbreviated version!
For detailed information about yapsin 1, go to the full flat file.

Word Map on EC 3.4.23.41

Reaction

hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions =

Synonyms

aspartic protease yapsin I, aspartic proteinase 3, Kex2, More, opsA, Yap3 gene product, yeast aspartic protease, yeast aspartic protease 3, YPS1, YPS7

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.41 yapsin 1

Reference

Reference on EC 3.4.23.41 - yapsin 1

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Olsen, V.; Cawley, N.X.; Loh, Y.P.
Yapsin1. Structure, biosynthesis, and specificity
Adv. Exp. Med. Biol.
436
315-319
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Kang, H.A.; Kim, S.J.; Choi, E.S.; Rhee, S.K.; Chung, B.H.
Efficient production of intact human parathyroid hormone in a Saccharomyces cerevisiae mutant deficient in yeast aspartic protease 3 (YAP3)
Appl. Microbiol. Biotechnol.
50
187-192
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Ledgerwood, E.C.; Brennan, S.O.; Cawley, N.X.; Loh, Y.P.; George, P.M.
Yeast aspartic protease 3 (Yap3) prefers substrates with basic residues in the P2, P1 and P2 positions
FEBS Lett.
383
67-71
1996
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cawley, N.X.; Olsen, V.; Zhang, C.F.; Chen, H.C.; Tan, M.; Loh, Y.P.
Activation and processing of non-anchored yapsin 1 (Yap3p)
J. Biol. Chem.
273
584-591
1998
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cawley, N.X.; Chen, H.C.; Beinfeld, M.C.; Loh, Y.P.
Specificity and kinetic studies on the cleavage of various prohormone mono- and paired-basic residue sites by yeast aspartic protease 3
J. Biol. Chem.
271
4168-4176
1996
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cool, D.R.; Louie, C.Y.; Loh, Y.P.
Yeast aspartic protease 3 is sorted to secretory granules and activated to process proopiomelanocortin in PC12 cells
Endocrinology
137
5441-5446
1996
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cawley, N.X.; Wong, M.; Pu, L.P.; Tam, W.; Loh, Y.P.
Secretion of yeast aspartic protease 3 is regulated by its carboxy-terminal tail: characterization of secreted YAP3p
Biochemistry
34
7430-7437
1995
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cawley, N.X.; Noe, B.D.; Loh, Y.P.
Purified yeast aspartic protease 3 cleaves anglerfish pro-somatostatin I and II at di- and monobasic sites to generate somatostatin-14 and -28
FEBS Lett.
332
273-276
1993
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Olsen, V.; Loh, Y.P.
In vivo processing of nonanchored Yapsin 1 (Yap3p)
Arch. Biochem. Biophys.
375
315-321
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cawley, N.X.; Chino, M.; Maldonado, A.; Rodriguez, Y.M.; Loh, Y.P.; Ellman, J.A.
Synthesis and characterization of the first potent inhibitor of yapsin 1. Implications for the study of yapsin-like enzymes
J. Biol. Chem.
278
5523-5530
2003
Saccharomyces cerevisiae (P32329), Saccharomyces cerevisiae
Manually annotated by BRENDA team
Bourbonnais, Y.; Larouche, C.; Tremblay, G.M.
Production of full-length human pre-elafin, an elastase specific inhibitor, from yeast requires the absence of a functional yapsin 1 (Yps1p) endoprotease
Protein Expr. Purif.
20
485-491
2000
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Krysan, D.J.; Ting, E.L.; Abeijon, C.; Kroos, L.; Fuller, R.S.
Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae
Eukaryot. Cell
4
1364-1374
2005
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Cawley, N.X.; Loh, Y.P.
Yapsin 1
Handbook of Proteolytic Enzymes (Barrett, J. ; Rawlings, N. D. ; Woessner, J. F. , eds. )
1
128-131
2004
Saccharomyces cerevisiae
-
Manually annotated by BRENDA team
Mizutani, O.; Furukawa, K.; Ichiyanagi, S.; Matsuda, Y.; Tokuoka, M.; Fujioka, T.; Yamagata, Y.; Gomi, K.; Abe, K.
Alternative processing of proproteins in Aspergilli kexB gene disruptants under hyperosmotic conditions
Biosci. Biotechnol. Biochem.
73
40-46
2009
Aspergillus oryzae (Q8NKB5)
Manually annotated by BRENDA team
Miyazaki, T.; Izumikawa, K.; Yamauchi, S.; Inamine, T.; Nagayoshi, Y.; Saijo, T.; Seki, M.; Kakeya, H.; Yamamoto, Y.; Yanagihara, K.; Miyazaki, Y.; Yasuoka, A.; Kohno, S.
The glycosylphosphatidylinositol-linked aspartyl protease Yps1 is transcriptionally regulated by the calcineurin-Crz1 and Slt2 MAPK pathways in Candida glabrata
FEMS Yeast Res.
11
449-456
2011
[Candida] glabrata
Manually annotated by BRENDA team
Cawley, N.X.; Portela-Gomes, G.; Lou, H.; Loh, Y.P.
Yapsin 1 immunoreactivity in {alpha}-cells of human pancreatic islets: implications for the processing of human proglucagon by mammalian aspartic proteases
J. Endocrinol.
210
181-187
2011
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Sohn, M.J.; Oh, D.B.; Kim, E.J.; Cheon, S.A.; Kwon, O.; Kim, J.Y.; Lee, S.Y.; Kang, H.A.
HpYPS1 and HpYPS7 encode functional aspartyl proteases localized at the cell surface in the thermotolerant methylotrophic yeast Hansenula polymorpha
Yeast
29
1-16
2012
Ogataea angusta (Q3L7F4), Ogataea angusta (Q5QT58)
Manually annotated by BRENDA team
Bairwa, G.; Rasheed, M.; Taigwal, R.; Sahoo, R.; Kaur, R.
GPI (glycosylphosphatidylinositol)-linked aspartyl proteases regulate vacuole homoeostasis in Candida glabrata
Biochem. J.
458
323-334
2014
[Candida] glabrata
Manually annotated by BRENDA team
Dube, A.K.; Belanger, M.; Gagnon-Arsenault, I.; Bourbonnais, Y.
N-terminal entrance loop of yeast Yps1 and O-glycosylation of substrates are determinant factors controlling the shedding activity of this GPI-anchored endopeptidase
BMC Microbiol.
15
50
2015
Saccharomyces cerevisiae (P32329), Saccharomyces cerevisiae ATCC 204508 (P32329)
Manually annotated by BRENDA team
Guan, B.; Lei, J.; Su, S.; Chen, F.; Duan, Z.; Chen, Y.; Gong, X.; Li, H.; Jin, J.
Absence of Yps7p, a putative glycosylphosphatidylinositol-linked aspartyl protease in Pichia pastoris, results in aberrant cell wall composition and increased osmotic stress resistance
FEMS Yeast Res.
12
969-979
2012
Komagataella pastoris, Komagataella pastoris GS115
Manually annotated by BRENDA team
Wu, M.; Shen, Q.; Yang, Y.; Zhang, S.; Qu, W.; Chen, J.; Sun, H.; Chen, S.
Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115
J. Ind. Microbiol. Biotechnol.
40
589-599
2013
Komagataella pastoris (Q5J879), Komagataella pastoris GS115 (Q5J879)
Manually annotated by BRENDA team
Yang, X.; Cong, H.; Song, J.; Zhang, J.
Heterologous expression of an aspartic protease gene from biocontrol fungus Trichoderma asperellum in Pichia pastoris
World J. Microbiol. Biotechnol.
29
2087-2094
2013
Trichoderma asperellum
Manually annotated by BRENDA team
Grbavac, A.; Canak, I.; Stuparevic, I.; Teparic, R.; Mrsa, V.
Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan
Biochim. Biophys. Acta Mol. Cell Res.
1864
507-515
2017
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
Manually annotated by BRENDA team
Cortes-Acosta, E.; Ibarra, J.; Ramiírez-Saad, H.; Vargas-Mendoza, C.; Villa-Tanaca, L.; Hernandez-Rodriguez, C.
Polymorphism in the regulatory regions of genes CgYPS1 and CgYPS7 encoding yapsins in Candida glabrata is associated with changes in expression levels
FEMS Yeast Res.
17
fox077
2017
[Candida] glabrata (A0A1S7BH59), [Candida] glabrata CBS138 (A0A1S7BH59)
Manually annotated by BRENDA team
Rapala-Kozik, M.; Bochenska, O.; Zajac, D.; Karkowska-Kuleta, J.; Gogol, M.; Zawrotniak, M.; Kozik, A.
Extracellular proteinases of Candida species pathogenic yeasts
Mol. Oral Microbiol.
33
113-124
2018
[Candida] glabrata
Manually annotated by BRENDA team