3.4.23.41: yapsin 1

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For detailed information about yapsin 1, go to the full flat file.

Reaction

hydrolyses various precursor proteins with Arg or Lys in P1, and commonly Arg or Lys also in P2. The P3 amino acid is usually non-polar, but otherwise additional basic amino acids are favourable in both non-prime and prime positions =

Synonyms

aspartic protease yapsin I, aspartic proteinase 3, Kex2, More, opsA, Yap3 gene product, yeast aspartic protease, yeast aspartic protease 3, YPS1, YPS7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.41 yapsin 1

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Results	in table
11	AA Sequence
3	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Expression
13	General Information
10	Inhibitors
3	Ki Value [mM]
6	KM Value [mM]
6	Localization
2	Metals/Ions
11	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
106	Organism
4	pH Optimum
1	pH Range
1	pI Value
6	Posttranslational Modification
6	Protein Variants
7	Purification (Commentary)
4	Reaction
1	Reaction Type
30	Reference
1	Specific Activity [micromol/min/mg]
36	Substrates and Products (Substrate)
7	Subunits
23	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

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Cloned on EC 3.4.23.41 - yapsin 1

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

expressed in Escherichia coli as a His-tagged fusion protein

Aspergillus oryzae

Q8NKB5

707789

expression in PC12 cells

Saccharomyces cerevisiae

-

36900

expression in Pichia pastoris

Trichoderma asperellum

-

735337

expression of C-terminally truncated proyapsin I in baculovirus/Sf9 cells

Saccharomyces cerevisiae

-

36898

expression of C-terminally truncated yapsin I in yeast

Saccharomyces cerevisiae

-

36898, 36901

gene yps1, DNA and amino acid sequence determination and analysis, expression of recombinant enzyme lacking the GPI-anchor in yeast cells

Saccharomyces cerevisiae

-

668790

gene YPS1, expression of wild-type and mutant enzymes in yeast strains

Saccharomyces cerevisiae

-

668451

overexpression in yeast

Saccharomyces cerevisiae

-

36895, 36897