3.4.23.40: Phytepsin

This is an abbreviated version, for detailed information about Phytepsin, go to the full flat file.

Reaction

Prefers hydrophobic residues Phe, Val, Ile, Leu, and Ala at P1 and P1', but also cleaves -Phe-/-Asp- and -Asp-/-Asp- bonds in 2S albumin from plant seeds =

Synonyms

Acid protease, Ap1, Aspartic proteinase, Aspartyl endoproteinase, Barley grain aspartic proteinase, Carboxyl proteinase, CardA, cardB, Cardosin, cardosin A, cardosin B, Cynarase, cynarase A, cynarase B, cynarase C, Edestinase, HvAP, Nepenthesin, Oryzasin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.40 Phytepsin

Reference

Reference on EC 3.4.23.40 - Phytepsin

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kervinen, J.; Sarkkinen, P.; Leena, N.K.; Saarma, M.
Hydrolytic specifity of barley grain aspartic proteinase
Phytochemistry
32
799-803
1993
Hordeum vulgare
Manually annotated by BRENDA team
Kervinen, J.; Törmäkangas, K.; Runeberg-Roos, P.; Guruprasad, K.; Blundell, T.; Teeri, T.H.
Structure and possible function of aspartic proteinases in barley and other plants
Adv. Exp. Med. Biol.
362
241-254
1995
Brassica napus, Cannabis sativa, Cucumis sativus, Cucurbita maxima, Cynara cardunculus, Drosera peltata, Fagopyrum esculentum, Hordeum vulgare, Nelumbo nucifera, Nepenthes macfarlanei, Nicotiana tabacum, Oryza sativa, Pinus banksiana, Pinus sylvestris, Solanum lycopersicum, Sorghum bicolor, Theobroma cacao, Triticum aestivum, Triticum durum x Haynaldia villosa
Manually annotated by BRENDA team
Asakura, T.; Watanabe, H.; Abe, K.; Arai, S.
Rice aspartic proteinase, oryzasin, expressed during seed ripening and germination, has a gene organization distinct from those of animal and microbial aspartic proteinases
Eur. J. Biochem.
232
77-83
1995
Oryza sativa
Manually annotated by BRENDA team
Runeberg-Roos, P.; Törmäkangas, K.; Ístman, A.
Primary structure of a barley-grain aspartic proteinase. A plant aspartic proteinase resembling mammalian cathepsin D.
Eur. J. Biochem.
202
1021-1027
1991
Hordeum vulgare
Manually annotated by BRENDA team
Guruprasad, K.; Törmäkangas, K.; Kervinen, J.; Blundell, T.L.
Comparative modelling of barley-grain aspartic proteinase: a structural rationale for observed hydrolytic specificity
FEBS Lett.
352
131-136
1994
Hordeum vulgare
Manually annotated by BRENDA team
Runeberg-Roos, P.; Kervinen, J.; Kovaleva, V.; Raikhel, N.V.; Gal, S.
The aspartic proteinase is a vacuolar enzyme that processes probarley lectin in vitro
Plant Physiol.
105
321-329
1994
Hordeum vulgare
Manually annotated by BRENDA team
Belozersky, M.A.; Sarbakanova, S.T.; Dunaevsky, Y.A.
Aspartic proteinase from wheat seeds: isolation, properties and action on gliadin
Planta
177
321-326
1998
Triticum aestivum
Manually annotated by BRENDA team
Sarkkinen, P.; Kalkkinen, N.; Tilgmenn, C.; siuro, J.; Mikola, L.
Aspartic proteinase from barley grains is related to mammalian lysosomal cathepsin D
Planta
186
317-323
1992
Hordeum vulgare
Manually annotated by BRENDA team
Törmäkangas, K.; Kervinen, J.; Ístman, A.; Teeri, T.
Tissue-specific localization of aspartic proteinase in developing and germinating barley grains
Planta
195
116-125
1994
Hordeum vulgare
-
Manually annotated by BRENDA team
Galleschi, L.; Andreoni, U.
A rapid and sensitive method of assaying the purified aspartic proteinase in cereals
Plant Physiol. Biochem.
28
793-797
1990
Triticum aestivum, Triticum durum x Haynaldia villosa
-
Manually annotated by BRENDA team
Galleschi, L.; Felicioli, F.
Purification, characterization and activation by anions of an aspartic proteinase isolated from soft wheat
Plant Sci.
98
15-24
1994
Triticum aestivum
-
Manually annotated by BRENDA team
Prasad, B.V.L.S.; Suguna, K.
Role of water molecules in the structure and function of aspartic proteinases
Acta Crystallogr. Sect. D
D58
250-259
2002
Hordeum vulgare
Manually annotated by BRENDA team
Park, H.; Kusakabe, I.; Sakakibara, Y.; Kobayashi, H.
Autoproteolytic processing of aspartic proteinase from sunflower seeds
Biosci. Biotechnol. Biochem.
65
702-705
2001
Helianthus annuus
Manually annotated by BRENDA team
Castanheira, P.; Samyn, B.; Sergeant, K.; Clemente, J.C.; Dunn, B.M.; Pires, E.; Van Beeumen, J.; Faro, C.
Activation, proteolytic processing, and peptide specificity of recombinant cardosin A
J. Biol. Chem.
280
13047-13054
2005
Cynara cardunculus
Manually annotated by BRENDA team
Sidrach, L.; Garcia-Canovas, F.; Tudela, J.; Rodriguez-Lopez, J.N.
Purification of cynarases from artichoke (Cynara scolymus L.): enzymatic properties of cynarase A
Phytochemistry
66
41-49
2005
Cynara cardunculus var. scolymus
Manually annotated by BRENDA team
Almeida, C.M.; Gomes, D.; Faro, C.; Simoes, I.
Engineering a cardosin B-derived rennet for sheep and goat cheese manufacture
Appl. Microbiol. Biotechnol.
99
269-281
2015
Cynara cardunculus, Cynara cardunculus (Q9XFX4)
Manually annotated by BRENDA team
Verissimo, P.; Faro, C.; Moir, A.J.; Lin, Y.; Tang, J.; Pires, E.
Purification, characterization and partial amino acid sequencing of two new aspartic proteinases from fresh flowers of Cynara cardunculus L.
Eur. J. Biochem.
235
762-768
1996
Cynara cardunculus, Cynara cardunculus (Q9XFX3), Cynara cardunculus (Q9XFX4)
Manually annotated by BRENDA team
Llorente, B.E.; Obregon, W.D.; Aviles, F.X.; Caffini, N.O.; Vairo-Cavalli, S.
Use of artichoke (Cynara scolymus) flower extract as a substitute for bovine rennet in the manufacture of Gouda-type cheese: characterization of aspartic proteases
Food Chem.
159
55-63
2014
Cynara cardunculus var. scolymus
Manually annotated by BRENDA team
Frazao, C.; Bento, I.; Costa, J.; Soares, C.M.; Verissimo, P.; Faro, C.; Pires, E.; Cooper, J.; Carrondo, M.A.
Crystal structure of cardosin A, a glycosylated and Arg-Gly-Asp-containing aspartic proteinase from the flowers of Cynara cardunculus L.
J. Biol. Chem.
274
27694-27701
1999
Cynara cardunculus, Cynara cardunculus (Q9XFX3)
Manually annotated by BRENDA team
Raimbault, A.K.; Zuily-Fodil, Y.; Soler, A.; Cruz de Carvalho, M.H.
A novel aspartic acid protease gene from pineapple fruit (Ananas comosus): cloning, characterization and relation to postharvest chilling stress resistance
J. Plant Physiol.
170
1536-1540
2013
Ananas comosus, Ananas comosus (K7P8F2)
Manually annotated by BRENDA team
Pereira, C.; Pereira, S.; Satiat-Jeunemaitre, B.; Pissarra, J.
Cardosin A contains two vacuolar sorting signals using different vacuolar routes in tobacco epidermal cells
Plant J.
76
87-100
2013
Cynara cardunculus (Q9XFX3)
Manually annotated by BRENDA team