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3.4.23.4: chymosin

This is an abbreviated version!
For detailed information about chymosin, go to the full flat file.

Word Map on EC 3.4.23.4

Reaction

Broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe105-/-Met-Ala bond in kappa-chain of casein =

Synonyms

CHY-MAX, CHY-MAX 200, chymase, chymosin, chymosin A, chymosin B, CYM, EC 3.4.4.3, More, Preprorennin, prochymosin, rCH, rennin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.4 chymosin

Inhibitors

Inhibitors on EC 3.4.23.4 - chymosin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-2-epoxy-3(p-nitrophenoxy)propane
-
-
alpha2-Macroglobulin
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Blood serum
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porcine and particularly equine serum impairs the coagulation of milk by chymosin, the inhibitor(s) may be heat labile, alpha2-macroglobulin may be the inhibitory substance
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Diazoacetylnorleucine methyl ester
-
in presence of Cu2+
EDTA
-
10 mM EDTA causes inhibition of 73.8% of the milk-clotting activity
iodoacetamide
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4 mM iodoacetamide causes inhibition of 7.2% of the milk-clotting activity
pepstatin
pepstatin A
Sn2+
-
28.8% inhibition at 1 mM
additional information
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phenylmethylsulfonyl fluoride does not affect the enzyme activity
-