3.4.23.38: plasmepsin I

This is an abbreviated version!
For detailed information about plasmepsin I, go to the full flat file.

Reaction

hydrolysis of the -Phe33-/-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule =

Synonyms

AH I, aspartic hemoglobinase I, malaria aspartic hemoglobinase, PFAPG, PfPM1, plasmepsin 1, plasmepsin I, plasmepsin-I, PLm I, PM I, PM-I, PMI

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.38 plasmepsin I

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Results	in table
3	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
44	IC50 Value
201	Inhibitors
139	Ki Value [mM]
18	KM Value [mM]
7	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
33	Organism
1	Pathway
6	PDB ID
8	pH Optimum
3	pH Range
5	Posttranslational Modification
1	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
2	Subunits
20	Synonyms
17	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.23.38 - plasmepsin I

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 7

Plasmodium falciparum

-

active over the range

648189

3.5 - 6

Plasmodium falciparum

-

pH 3.5: about 75% of maximal activity, pH 6.0: about 40% of maximal activity, hydrolysis of Leu-Glu-Arg-Ile-Phe-Phe(NO2)-Ser-Phe

648190

4 - 6.5

Plasmodium falciparum

-

pH 4.0: about 20% of maximal activity, pH 4.5: about 90% of maximal activity, pH 6.0: about 60% of maximal activity, pH 6.5: about 30% of maximal activity

648178