3.4.23.38: plasmepsin I

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For detailed information about plasmepsin I, go to the full flat file.

Reaction

hydrolysis of the -Phe33-/-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule =

Synonyms

AH I, aspartic hemoglobinase I, malaria aspartic hemoglobinase, PFAPG, PfPM1, plasmepsin 1, plasmepsin I, plasmepsin-I, PLm I, PM I, PM-I, PMI

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.38 plasmepsin I

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Results	in table
3	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
1	Crystallization (Commentary)
1	General Information
44	IC50 Value
201	Inhibitors
139	Ki Value [mM]
18	KM Value [mM]
7	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
33	Organism
1	Pathway
6	PDB ID
8	pH Optimum
3	pH Range
5	Posttranslational Modification
1	Protein Variants
5	Purification (Commentary)
1	Reaction
1	Reaction Type
33	Reference
5	Source Tissue
1	Specific Activity [micromol/min/mg]
38	Substrates and Products (Substrate)
2	Subunits
20	Synonyms
17	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.23.38 - plasmepsin I

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

recombinant PMI as apoenzyme and in complex with the potent peptidic inhibitor, (4R)-3-[(2S,3S)-3-{[(2,6-dimethylphenoxy)acetyl]amino}-2-hydroxy-4-phenylbutanoyl]-N-[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide, i. e. KNI-10006, at the resolution of 2.4 and 3.1 A, respectively. The apoenzyme crystallizes in the orthorhombic space group P212121 with two molecules in the asymmetric unit. The KNI-10006 bound enzyme crystallized in the tetragonal space group P43 with four molecules in the asymmetric unit a. In the PMI–KNI-10006 complex, the inhibitors are bound identically to all four enzyme molecules, with the opposite directionality of the main chain of KNI-10006 relative to the direction of the enzyme substrates

Plasmodium falciparum

P39898

718040