3.4.23.36: Signal peptidase II

This is an abbreviated version!
For detailed information about Signal peptidase II, go to the full flat file.

Word Map on EC 3.4.23.36

3.4.23.36

globomycin

intramembrane

3hpalmitate

sppl2b

lipobox

lipid-modified

diacylglyceryl

spp-like

isoleucyl-trna

braun

intramembrane-cleaving

triacylated

medicine

Reaction

Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa-/-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains =

Synonyms

EC 3.4.99.35, Leader peptidase II, lipoprotein signal peptidase, lipoprotein signal peptidase II, lipoprotein-specific (typeII) signal peptidase, lipoprotein-specific signal peptidase, lipoprotein-specific type II signal peptidase, LspA, More, Premurein leader peptidase, Premurein leader proteinase, Premurein-leader peptidase, Prolipoprotein signal peptidase, Proteinase, premurein leader, Signal peptide peptidase, signal peptide peptidase-like 2a, Sp0928, SPase II, SpiI, SPP, SPPL2a, SPPL2c, type II signal peptidase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.36 Signal peptidase II

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Results	in table
6	Activating Compound
41930	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
68	Disease/ Diagnostics
1	Expression
12	General Information
1	General Stability
24	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
15	Localization
8	Metals/Ions
8	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
592	Organism
1	Pathway
10	PDB ID
8	pH Optimum
2	Posttranslational Modification
19	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
34	Reference
8	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
51	Substrates and Products (Substrate)
9	Subunits
50	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

Inhibitors

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Inhibitors on EC 3.4.23.36 - Signal peptidase II

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(Z-LL)2-ketone

chymostatin

Globomycin

HgCl2

lauroyl sarcoside

Myxobacteria antibiotic TA

Escherichia coli

TA inhibits pro-lipoprotein processing in whole cells, similar to globomycin, thus preventing outer membrane localization of lipoproteins LpoA and LpoB and blocking their essential interactions with PBP1A and PBP1B

NEM

octylglucoside

pepstatin

Phenylethyl alcohol

phenylmethylsulfonyl fluoride

Escherichia coli

30813

tosyl arginyl methyl ester

Escherichia coli

668802

tosyl-Arg methyl ester

Escherichia coli

30813