3.4.23.36: Signal peptidase II

This is an abbreviated version!
For detailed information about Signal peptidase II, go to the full flat file.

Word Map on EC 3.4.23.36

3.4.23.36

globomycin

intramembrane

3hpalmitate

sppl2b

lipobox

lipid-modified

diacylglyceryl

spp-like

isoleucyl-trna

braun

intramembrane-cleaving

triacylated

medicine

Reaction

Release of signal peptides from bacterial membrane prolipoproteins including murein prolipoprotein. Hydrolyses -Xaa-Yaa-Zaa-/-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral sidechains =

Synonyms

EC 3.4.99.35, Leader peptidase II, lipoprotein signal peptidase, lipoprotein signal peptidase II, lipoprotein-specific (typeII) signal peptidase, lipoprotein-specific signal peptidase, lipoprotein-specific type II signal peptidase, LspA, More, Premurein leader peptidase, Premurein leader proteinase, Premurein-leader peptidase, Prolipoprotein signal peptidase, Proteinase, premurein leader, Signal peptide peptidase, signal peptide peptidase-like 2a, Sp0928, SPase II, SpiI, SPP, SPPL2a, SPPL2c, type II signal peptidase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.36 Signal peptidase II

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Results	in table
6	Activating Compound
41930	AA Sequence
1	Application
1	CAS Registry Number
15	Cloned(Commentary)
6	Cofactor
1	Crystallization (Commentary)
68	Disease/ Diagnostics
1	Expression
12	General Information
1	General Stability
24	Inhibitors
1	Ki Value [mM]
2	KM Value [mM]
15	Localization
8	Metals/Ions
8	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
592	Organism
1	Pathway
10	PDB ID
8	pH Optimum
2	Posttranslational Modification
19	Protein Variants
4	Purification (Commentary)
1	Reaction
1	Reaction Type
34	Reference
8	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
51	Substrates and Products (Substrate)
9	Subunits
50	Synonyms
1	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]

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Cloned on EC 3.4.23.36 - Signal peptidase II

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4 entries

DNA and amino acid sequence determination and analysis

3 entries

enzyme overexpression in Escherichia coli confers high resistance to globomycin

Myxococcus xanthus

668802

expressed in Escherichia coli DH5alpha cells

Streptococcus gordonii

708937

expressed in MelJuso cells

Mus musculus

752711

expression of Sp0928 protects Escherichia coli against the Lsp antagonist globomycin

Streptococcus pneumoniae

682007

gene lsp, DNA and amino acid sequence determination and analysis, overexpression in Escherichia coli under control of the trp promoter

Escherichia coli

668802

ORF Rv1539, gene lspA, from strain H37Rv, DNA and amino acid sequence determination and analysis

Mycobacterium tuberculosis

670307

overexpression of Rickettsia typhi lspA in Escherichia coli confers increased globomycin resistance. Recombinant lspA from significantly restores the growth of temperature-sensitive Escherichia coli Y815 at the nonpermissive temperature, supporting its biological activity as SPase II in prolipoprotein processing

Rickettsia typhi

680486

wild-type lsp gene amplified by PCR, cloned into pGDL48 and used to transform Bacillus subtilis 8G5lsp, lacking the lsp gene

Bacillus subtilis

651951