3.4.23.34: cathepsin E

This is an abbreviated version!
For detailed information about cathepsin E, go to the full flat file.

Reaction

similar to cathepsin D, but slightly broader specificity =

Synonyms

CatE, Cathepsin D-like acid proteinase, cathepsin D-like aspartic proteinase, cathepsin D-like protease, Cathepsin D-type proteinase, cathepsin E, Cathepsin E-like acid proteinase, CE, CTSE, EMAP, erythrocyte membrane acid proteinase, Erythrocyte membrane aspartic proteinase, gastric mucosa non-pepsin acid proteinase, More, Non-pepsin proteinase, slow moving proteinase, Slow-moving proteinase, SMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.34 cathepsin E

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Results	in table
12	Activating Compound
695	AA Sequence
7	Application
1	CAS Registry Number
34	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
372	Disease/ Diagnostics
3	Expression
3	General Information
2	General Stability
15	IC50 Value
118	Inhibitors
1	kcat/KM [mM/s]
18	Ki Value [mM]
51	KM Value [mM]
65	Localization
1	Metals/Ions
55	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
70	Organism
2	PDB ID
12	pH Optimum
9	pH Range
18	pH Stability
1	pI Value
18	Posttranslational Modification
13	Protein Variants
25	Purification (Commentary)
1	Reaction
2	Reaction Type
70	Reference
193	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
157	Substrates and Products (Substrate)
35	Subunits
35	Synonyms
19	Temperature Optimum [°C]
10	Temperature Stability [°C]
60	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.23.34 - cathepsin E

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

3 - 5.5

Homo sapiens

-

6 h at 37°C, unstable

30800

4

Cavia porcellus

-

2 h at 28°C, 60-65% loss of activity

30789

5

Cavia porcellus

-

2 h at 28°C, 45% (dimer) and 55% (monomer) loss of activity

30789

5.8

2 entries

6

Cavia porcellus

-

2 h at 28°C, 20% loss of activity

30789

6 - 7.4

Homo sapiens

-

6 h at 37°C, rather stable

30800

7

Cavia porcellus

-

2 h at 28°C, stable (dimer), 10% loss of activity (monomer)

30789

7.5

Cavia porcellus

-

2 h at 28°C, 50% loss of monomeric enzyme activity

30789

8

Cavia porcellus

-

2 h at 28°C, 10% (dimer) and 70% (monomer) loss of activity

30789

8.8

Cavia porcellus

-

2 h at 28°C, 20% (dimer) and 95% (monomer) loss of activity

30789

additional information

7 entries

5.8

Homo sapiens

-

75% loss of activity of erythrocyte membrane aspartic proteinase from human erythrocytes, inactivation of slow-moving proteinase from human gastric mucosa and cathepsin E from rat spleen, instable above pH 5.8

30780

5.8

Rattus norvegicus

-

75% loss of activity of erythrocyte membrane aspartic proteinase from human erythrocytes, inactivation of slow-moving proteinase from human gastric mucosa and cathepsin E from rat spleen, instable above pH 5.8

30780

additional information

Cavia porcellus

-

monomeric cathepsin E is much less stable in weakly alkaline solution than dimeric form

30798

additional information

Cavia porcellus

-

dimer is stable at weakly alkaline pH while monomer rapidly loses activity above pH 7

30789

additional information

Homo sapiens

-

the pH-stability of the mutant monomeric form in alkaline solution is markedly reduced

30802

additional information

Homo sapiens

-

resists inactivation upon sequential exposure to acid and alkaline conditions

30782

additional information

Homo sapiens

-

monomeric cathepsin E is much less stable in weakly alkaline solution than dimeric form

30798

additional information

Oryctolagus cuniculus

-

monomeric cathepsin E is much less stable in weakly alkaline solution than dimeric form

30798

additional information

Rattus norvegicus

-

monomeric cathepsin E is much less stable in weakly alkaline solution than dimeric form

30798