3.4.23.34: cathepsin E

This is an abbreviated version!
For detailed information about cathepsin E, go to the full flat file.

Reaction

similar to cathepsin D, but slightly broader specificity =

Synonyms

CatE, Cathepsin D-like acid proteinase, cathepsin D-like aspartic proteinase, cathepsin D-like protease, Cathepsin D-type proteinase, cathepsin E, Cathepsin E-like acid proteinase, CE, CTSE, EMAP, erythrocyte membrane acid proteinase, Erythrocyte membrane aspartic proteinase, gastric mucosa non-pepsin acid proteinase, More, Non-pepsin proteinase, slow moving proteinase, Slow-moving proteinase, SMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.34 cathepsin E

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
12	Activating Compound
695	AA Sequence
7	Application
1	CAS Registry Number
34	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
372	Disease/ Diagnostics
3	Expression
3	General Information
2	General Stability
15	IC50 Value
118	Inhibitors
1	kcat/KM [mM/s]
18	Ki Value [mM]
51	KM Value [mM]
65	Localization
1	Metals/Ions
55	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
70	Organism
2	PDB ID
12	pH Optimum
9	pH Range
18	pH Stability
1	pI Value
18	Posttranslational Modification
13	Protein Variants
25	Purification (Commentary)
1	Reaction
2	Reaction Type
70	Reference
193	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
157	Substrates and Products (Substrate)
35	Subunits
35	Synonyms
19	Temperature Optimum [°C]
10	Temperature Stability [°C]
60	Turnover Number [1/s]

Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Substrates Products on EC 3.4.23.34 - cathepsin E

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Substrate/Product Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

(7-methoxycoumarin-4-yl)-acetyl-Gly-Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu-Lys(2,4-dinitrophenyl)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

fluorogenic synthetic substrate

651797

-

651797

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

-

667861

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe + Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2

2 entries

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2 + H2O

?

Homo sapiens

-

-

709450

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 + H2O

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe + Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2

Homo sapiens

-

-

670765

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

-

669151

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O

?

3 entries

(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Ser-Ala-Phe-Leu-Ala-Phe-Lys(Dnp)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

-

667861

-

-

?

(7-methoxycoumarin-4-yl)acetyl-L-Ala-Gly-L-Phe-L-Ser-L-Leu-L-Pro-L-Ala-L-Lys(Dnp)-D-Arg-amide + H2O

(7-methoxycoumarin-4-yl)acetyl-L-Ala-Gly-L-Phe-L-Ser-L-Leu + L-Pro-L-Ala-L-Lys(Dnp)-D-Arg-amide

Homo sapiens

-

due to the close proximity of a Mca-donor and a Dnp-acceptor, near complete intramolecular quenching effect is achieved in the substrate's intact state. After the proteolytic cleavage of the hydrophobic motif, both Mca and Dnp are further apart, resulting in bright fluorescence

717271

substrate shows a 265fold difference in the net fluorescence signals between cathepsins E and D. This cathepsin E selectivity is established by having Leu-Pro residues at the scissile peptide bond

-

?

Acetyl-substance P + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Acetyl-substance P(2-11) + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Acetyl-substance P(3-11) + H2O

?

Cavia porcellus

-

-

30798

-

-

?

acidic fibroblast growth factor + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Acidic fibroblast growth factor fragment 102-111 + H2O

His-Ala-Glu-Lys-His-Trp-Phe + Val-Gly-Leu

2 entries

antigens presented by MHC class II molecules + H2O

?

Homo sapiens

-

-

651042

-

651042

?

Arg-modified substance P + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Basic fibroblast growth factor fragment 106-120 + H2O

?

2 entries

big ET-1 + H2O

?

2 entries

Bovine gamma-globulin + H2O

Hydrolyzed bovine gamma-globulin

3 entries

Bovine serum albumin + H2O

?

Mus musculus

-

-

755520

-

-

?

Bovine serum albumin + H2O

Hydrolyzed bovine serum albumin

5 entries

casein + H2O

hydrolyzed casein

6 entries

Cholecystokinin 8 + H2O

Asp-Tyr-Met-Gly-Trp + Met-Asp-Phe-NH2

2 entries

Cytochrome c + H2O

Hydrolyzed cytochrome c

Cavia porcellus

-

pH 5, at 2.5% (dimeric enzyme) or 2.3% (monomeric enzyme) the rate of hemoglobin hydrolysis

30789

-

30789

?

DED-[5-[(2-aminoethyl)amino]naphthalene-1-sulfonyl]-KPILFFRLGK-[4-(4-dimethylaminophenylazo)benzoic acid] + H2O

?

Homo sapiens

-

-

669836

-

-

?

dynorphin A + H2O

hydrolyzed dynorphin A

3 entries

Egg albumin + H2O

Hydrolyzed egg albumin

2 entries

Eledoisin + H2O

Pyro-Glu-Pro-Ser-Lys-Asp-Ala-Phe + Ile-Gly-Leu-Met-NH2

2 entries

glucagon + ATP + H2O

hydrolyzed glucagon + ?

Mus musculus

-

is digested at pH 4.0 but not at pH 7.4

677973

-

-

?

Hemoglobin + H2O

?

Rattus norvegicus

-

denatured

651797

-

651797

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

12 entries

Human beta-endorphin + H2O

Hydrolyzed human beta-endorphin

2 entries

Human endothelin precursor big ET-1 + H2O

Human endothelin precursor ET-1 + respective C-terminal fragment

4 entries

Human endothelin precursor big ET-2 + H2O

Human endothelin precursor ET-2 + respective C-terminal fragment

Homo sapiens

-

cleavage site: Trp-Val

30790

-

30790

?

Human endothelin precursor big ET-3 + H2O

Huamn endothelin precursor ET-3 + respective C-terminal fragment

Homo sapiens

-

cleavage site: Trp-Ile

30790

-

30790

?

Human gamma-globulin + H2O

Hydrolyzed human gamma-globulin

Cavia porcellus

-

pH 5, at 0.5% (dimeric enzyme) or 0.6% (monomeric enzyme) the rate of hemoglobin hydrolysis

30789

-

30789

?

Human renin substrate + H2O

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His

2 entries

Immunoglobulin + H2O

?

Homo sapiens

-

least active gastric protease for this substrate

30792

-

-

?

Kassinin + H2O

Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe + Val-Gly-Leu-Met-NH2

2 entries

Lys-Pro-Ala-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ala-Glu-Phe + (4-nitro)Phe-Arg-Leu

Cavia porcellus

-

-

30798

-

30798

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

11 entries

Membrane proteins + H2O

?

Homo sapiens

-

-

30783

-

-

?

MOCAc-Gly-Lys-Pro-Ile-Ile-Phe-Phe-Arg-Leu-Lys(DnP)-D-Arg-NH2 + H2O

?

Rattus norvegicus

P16228

-

699574

-

-

?

MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

-

700517

-

-

?

MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 + H2O

MOCAc-Gly-Lys-Pro-Ile-Leu-Phe + Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2

Homo sapiens

-

-

679774

-

-

?

MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O

?

Mus musculus

-

-

754975

-

-

?

MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(DNP)-D-Arg-NH2 + H2O

hydrolyzed MOCAc-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(DNP)-D-Arg-NH2

Homo sapiens

-

-

678531

-

-

?

N-succinyl-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-4-methyl-7-coumaryl-amide + H2O

?

Meloidogyne incognita

Q1A2Z2

-

697815

-

-

?

Neurokinin A + H2O

His-Lys-Thr-Asp-Ser-Phe + Val-Gly-Leu-Met-NH2

2 entries

neurotensin + H2O

hydrolyzed neurotensin

Mus musculus

-

no cleavage at pH 7.4

677973

-

-

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

7 entries

Porcine renin substrate + H2O

Acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Leu-Val-Tyr-Ser

2 entries

Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Pro-Thr-Ile-Phe + (4-nitro)Phe-Arg-Leu

5 entries

Pro-Thr-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Thr-Glu-Phe + (4-nitro)Phe-Arg-Leu

Cavia porcellus

-

-

30798

-

30798

?

Reduced and carboxymethylated bovine pancreatic ribonuclease A + H2O

Hydrolyzed bovine pancreatic RCm ribonuclease A

Homo sapiens

-

-

30794

-

30794

?

reduced carboxymethylated(RCm-)ribonuclease A + H2O

?

Homo sapiens

-

-

653779

-

653779

?

renin + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Substance P + H2O

Arg-Pro-Lys-Pro-Gln-Gln-Phe + Phe-Gly-Leu-Met-NH2

4 entries

Substance P(1-9) + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Substance P(2-11) + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Substance P(3-11) + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Substance P(4-11) + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Tachykinins + H2O

?

4 entries

[His10]-substance P + H2O

?

Cavia porcellus

-

-

30798

-

-

?

[Tyr8]-substance P + H2O

?

Cavia porcellus

-

-

30798

-

-

?

additional information

?

-

6 entries

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe + Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2

Homo sapiens

-

-

677990

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2

(7-methoxycoumarin-4-yl)acetyl-Gly-Lys-Pro-Ile-Leu-Phe + Phe-Arg-Leu-Lys(dinitrophenyl)-D-Arg-NH2

Mus musculus

-

-

677990

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O

?

Homo sapiens

-

most sensitive and selective substrate for cathepsin E. This substrate might represent a useful tool for monitoring and accurately quantifying cathepsin E, even in crude enzyme preparations

667861

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

-

669151

-

-

?

(7-methoxycoumarin-4-yl)acetyl-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH2 + H2O

?

Rattus norvegicus

-

most sensitive and selective substrate for cathepsin E. This substrate might represent a useful tool for monitoring and accurately quantifying cathepsin E, even in crude enzyme preparations

667861

-

-

?

Acidic fibroblast growth factor fragment 102-111 + H2O

His-Ala-Glu-Lys-His-Trp-Phe + Val-Gly-Leu

Cavia porcellus

-

i.e. His-Ala-Glu-Lys-His-Trp-Phe-Val-Gly-Leu or acidic FGF 102-111

30798

-

30798

?

Acidic fibroblast growth factor fragment 102-111 + H2O

His-Ala-Glu-Lys-His-Trp-Phe + Val-Gly-Leu

Oryctolagus cuniculus

-

i.e. His-Ala-Glu-Lys-His-Trp-Phe-Val-Gly-Leu or acidic FGF 102-111

30798

-

30798

?

Basic fibroblast growth factor fragment 106-120 + H2O

?

Cavia porcellus

-

i.e. Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-Val-Ala-Leu-Lys-Arg or basic FGF 106-120, major cleavage site: Tyr-Val, minor site: Trp-Tyr

30798

-

-

?

Basic fibroblast growth factor fragment 106-120 + H2O

?

Oryctolagus cuniculus

-

i.e. Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-Val-Ala-Leu-Lys-Arg or basic FGF 106-120, major cleavage site: Tyr-Val, minor site: Trp-Tyr

30798

-

-

?

big ET-1 + H2O

?

Cavia porcellus

-

-

30798

-

-

?

big ET-1 + H2O

?

Homo sapiens

-

-

30790, 30798

-

-

?

Bovine gamma-globulin + H2O

Hydrolyzed bovine gamma-globulin

Cavia porcellus

-

-

30798

-

-

?

Bovine gamma-globulin + H2O

Hydrolyzed bovine gamma-globulin

Lithobates catesbeianus

-

pH 2.5, at 2.3% the rate of hemoglobin hydrolysis

30797

-

30797

?

Bovine gamma-globulin + H2O

Hydrolyzed bovine gamma-globulin

Rattus norvegicus

-

-

30798

-

-

?

Bovine serum albumin + H2O

Hydrolyzed bovine serum albumin

Cavia porcellus

-

-

30798

-

-

?

Bovine serum albumin + H2O

Hydrolyzed bovine serum albumin

Cavia porcellus

-

pH 5, at 3.6% (dimeric enzyme) or 4.1% (monomeric enzyme) the rate of hemoglobin hydrolysis

30789

-

30789

?

Bovine serum albumin + H2O

Hydrolyzed bovine serum albumin

Homo sapiens

-

-

30798

-

-

?

Bovine serum albumin + H2O

Hydrolyzed bovine serum albumin

Lithobates catesbeianus

-

pH 2.5 at 14% the rate of hemoglobin hydrolysis

30797

-

-

?

Bovine serum albumin + H2O

Hydrolyzed bovine serum albumin

Rattus norvegicus

-

-

30798

-

-

?

casein + H2O

hydrolyzed casein

Cavia porcellus

-

-

30798

-

-

?

casein + H2O

hydrolyzed casein

Cavia porcellus

-

pH 5, at 9.1% (dimeric enzyme) or 8.9% (monomeric enzyme) the rate of hemoglobin hydrolysis

30789

-

-

?

casein + H2O

hydrolyzed casein

Homo sapiens

-

-

30784, 30798

-

-

?

casein + H2O

hydrolyzed casein

Homo sapiens

-

at pH 5.5

30793

-

-

?

casein + H2O

hydrolyzed casein

Lithobates catesbeianus

-

at 2.3% the rate of hemoglobin hydrolysis

30797

-

30797

?

casein + H2O

hydrolyzed casein

Rattus norvegicus

-

-

30798

-

-

?

Cholecystokinin 8 + H2O

Asp-Tyr-Met-Gly-Trp + Met-Asp-Phe-NH2

Cavia porcellus

-

i.e. Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2, cleavage site: Trp-Met

30798

-

30798

?

Cholecystokinin 8 + H2O

Asp-Tyr-Met-Gly-Trp + Met-Asp-Phe-NH2

Oryctolagus cuniculus

-

i.e. Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2, cleavage site: Trp-Met

30798

-

30798

?

dynorphin A + H2O

hydrolyzed dynorphin A

Cavia porcellus

-

cleavage site: Phe4-Leu5

30798

-

30798

?

dynorphin A + H2O

hydrolyzed dynorphin A

Mus musculus

-

no cleavage at pH 7.4

677973

-

-

?

dynorphin A + H2O

hydrolyzed dynorphin A

Oryctolagus cuniculus

-

cleavage site: Phe4-Leu5

30798

-

30798

?

Egg albumin + H2O

Hydrolyzed egg albumin

Cavia porcellus

-

pH 5, at 1% (dimeric enzyme) or 1.1% (monomeric enzyme) the rate of hemoglobin hydrolysis

30789

-

30789

?

Egg albumin + H2O

Hydrolyzed egg albumin

Cavia porcellus

-

i.e. ovalbumin

30798

-

30798

?

Eledoisin + H2O

Pyro-Glu-Pro-Ser-Lys-Asp-Ala-Phe + Ile-Gly-Leu-Met-NH2

Cavia porcellus

-

i.e. pyro-Glu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2, cleavage site: Phe-Ile

30798

-

30798

?

Eledoisin + H2O

Pyro-Glu-Pro-Ser-Lys-Asp-Ala-Phe + Ile-Gly-Leu-Met-NH2

Oryctolagus cuniculus

-

i.e. pyro-Glu-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2, cleavage site: Phe-Ile

30798

-

30798

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Cavia porcellus

-

-

30798

-

30798

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Cavia porcellus

-

preferred substrate

30789

-

30789

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Cavia porcellus

-

at pH 2 the two catalytically active subunits have the same activity vs. hemoglobin, but at pH 5 they have a slightly higher activity than the enzyme dimer

30789

-

30789

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Homo sapiens

-

-

30793, 30795, 30796

-

-

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Homo sapiens

-

-

30798

-

30798

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Homo sapiens

-

acid denatured form

30778, 30783, 30799

-

-

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Homo sapiens

-

bovine

30778, 30799

-

-

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Lithobates catesbeianus

-

preferred substrate

30797

-

-

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Rattus norvegicus

-

-

30779

-

-

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Rattus norvegicus

-

-

30798

-

30798

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Rattus norvegicus

-

acid denatured form

30778, 30803

-

-

?

Hemoglobin + H2O

Hydrolyzed hemoglobin

Rattus norvegicus

-

bovine

30778, 30803

-

-

?

Human beta-endorphin + H2O

Hydrolyzed human beta-endorphin

Cavia porcellus

-

major cleavage site: Leu17-Phe18, minor site: Thr16-Leu17

30798

-

30798

?

Human beta-endorphin + H2O

Hydrolyzed human beta-endorphin

Oryctolagus cuniculus

-

major cleavage site: Leu17-Phe18, minor site: Thr16-Leu17

30798

-

30798

?

Human endothelin precursor big ET-1 + H2O

Human endothelin precursor ET-1 + respective C-terminal fragment

Cavia porcellus

-

cleavage site: Trp-Val

30798

-

30798

?

Human endothelin precursor big ET-1 + H2O

Human endothelin precursor ET-1 + respective C-terminal fragment

Homo sapiens

-

cleavage site: Trp-Val

30790

-

30790

?

Human endothelin precursor big ET-1 + H2O

Human endothelin precursor ET-1 + respective C-terminal fragment

Homo sapiens

-

cleavage site: Trp-Val

30798

-

30798

?

Human endothelin precursor big ET-1 + H2O

Human endothelin precursor ET-1 + respective C-terminal fragment

Oryctolagus cuniculus

-

cleavage site: Trp-Val

30798

-

30798

?

Human renin substrate + H2O

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His

Cavia porcellus

-

i.e. angiotensinogen fragment 1-13 or Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His, cleavage site: Leu-Val

30798

-

30798

?

Human renin substrate + H2O

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Val-Ile-His

Oryctolagus cuniculus

-

i.e. angiotensinogen fragment 1-13 or Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His, cleavage site: Leu-Val

30798

-

30798

?

Kassinin + H2O

Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe + Val-Gly-Leu-Met-NH2

Cavia porcellus

-

i.e. Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe-Val-Gly-Leu-Met-NH2, cleavage site: Phe-Val

30798

-

30798

?

Kassinin + H2O

Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe + Val-Gly-Leu-Met-NH2

Oryctolagus cuniculus

-

i.e. Asp-Val-Pro-Lys-Ser-Asp-Gln-Phe-Val-Gly-Leu-Met-NH2, cleavage site: Phe-Val

30798

-

30798

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Cavia porcellus

-

synthetic chromogenic peptide, less suitable peptide substrate than substance P or other tachykinins

30798

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

-

30780

-

30780

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

-

30784, 30793, 30795, 30796, 30801, 30802

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

synthetic chromogenic peptide, less suitable peptide substrate than substance P or other tachykinins

30798

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

pH 7.4

30787

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

no activation by ATP

30787

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Oryctolagus cuniculus

-

-

30780

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Oryctolagus cuniculus

-

synthetic chromogenic peptide, less suitable peptide substrate than substance P or other tachykinins

30798

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Rattus norvegicus

-

-

30780

-

30780

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Rattus norvegicus

-

synthetic chromogenic peptide, less suitable peptide substrate than substance P or other tachykinins

30798

-

-

?

Lys-Pro-Ile-Glu-Phe-(4-nitro)Phe-Arg-Leu + H2O

Lys-Pro-Ile-Glu-Phe + (4-nitro)Phe-Arg-Leu

Rattus norvegicus

-

i.e. RS-6

30803

-

-

?

Neurokinin A + H2O

His-Lys-Thr-Asp-Ser-Phe + Val-Gly-Leu-Met-NH2

Cavia porcellus

-

i.e. His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2, cleavage site: Phe-Val

30798

-

30798

?

Neurokinin A + H2O

His-Lys-Thr-Asp-Ser-Phe + Val-Gly-Leu-Met-NH2

Oryctolagus cuniculus

-

i.e. His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2, cleavage site: Phe-Val

30798

-

30798

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Cavia porcellus

-

cleavage sites

30798

-

-

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Homo sapiens

-

-

30794

-

30794

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Homo sapiens

-

cleavage sites

30798

-

-

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Homo sapiens

-

no activation by ATP

30787

-

30787

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Homo sapiens

-

cleavage specificity changes significantly with pH, e.g. cleaves Glu13-Ala14 only at pH 7.4

30787

-

30787

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Oryctolagus cuniculus

-

cleavage sites

30798

-

-

?

Oxidized insulin B-chain + H2O

Hydrolyzed oxidized insulin B-chain

Rattus norvegicus

-

cleavage sites

30798

-

-

?

Porcine renin substrate + H2O

Acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Leu-Val-Tyr-Ser

Cavia porcellus

-

i.e. angiotensinogen fragment 1-14 acetate salt or acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, cleavage site: Leu-Leu

30798

-

30798

?

Porcine renin substrate + H2O

Acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu + Leu-Val-Tyr-Ser

Oryctolagus cuniculus

-

i.e. angiotensinogen fragment 1-14 acetate salt or acetyl-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, cleavage site: Leu-Leu

30798

-

30798

?

Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Pro-Thr-Ile-Phe + (4-nitro)Phe-Arg-Leu

Cavia porcellus

-

-

30798

-

-

?

Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Pro-Thr-Ile-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

-

30795, 30796, 30798

-

-

?

Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Pro-Thr-Ile-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

synthetic chromogenic peptide

30780

-

30780

?

Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Pro-Thr-Ile-Phe + (4-nitro)Phe-Arg-Leu

Homo sapiens

-

synthetic chromogenic peptide

30784, 30793, 30801, 30802

-

-

?

Pro-Pro-Thr-Ile-Phe-(4-nitro)Phe-Arg-Leu + H2O

Pro-Pro-Thr-Ile-Phe + (4-nitro)Phe-Arg-Leu

Rattus norvegicus

-

synthetic chromogenic peptide

30780

-

30780

?

Substance P + H2O

Arg-Pro-Lys-Pro-Gln-Gln-Phe + Phe-Gly-Leu-Met-NH2

Cavia porcellus

-

i.e. Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, best peptide substrate, cleavage site: Phe-Phe

30798

-

30798

?

Substance P + H2O

Arg-Pro-Lys-Pro-Gln-Gln-Phe + Phe-Gly-Leu-Met-NH2

Homo sapiens

-

i.e. Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, best peptide substrate, cleavage site: Phe-Phe

30798

-

30798

?

Substance P + H2O

Arg-Pro-Lys-Pro-Gln-Gln-Phe + Phe-Gly-Leu-Met-NH2

Oryctolagus cuniculus

-

i.e. Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, best peptide substrate, cleavage site: Phe-Phe

30798

-

30798

?

Substance P + H2O

Arg-Pro-Lys-Pro-Gln-Gln-Phe + Phe-Gly-Leu-Met-NH2

Rattus norvegicus

-

i.e. Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, best peptide substrate, cleavage site: Phe-Phe

30798

-

30798

?

Tachykinins + H2O

?

Cavia porcellus

-

-

30798

-

-

?

Tachykinins + H2O

?

Homo sapiens

-

-

30798

-

-

?

Tachykinins + H2O

?

Oryctolagus cuniculus

-

-

30798

-

-

?

Tachykinins + H2O

?

Rattus norvegicus

-

-

30798

-

-

?

additional information

?

-

Homo sapiens

-

no hydrolysis of synthetic peptides corresponding to residues His16-His27 and His16-Ser38 in the big ET-1 sequence

30790

-

-

?

additional information

?

-

Homo sapiens

-

milk-clotting activity is twice as high as that of pepsinogen and gastricin

30792

-

-

?

additional information

?

-

Homo sapiens

-

degradation of protein antigens, crucial step in the initiation of a T-cell mediated immune response

651042

-

651042

?

additional information

?

-

Homo sapiens

-

cathepsin E has an important role in the class II MHC Ag processing pathway within dendritic cells

669718

-

-

?

additional information

?

-

Mus musculus

-

cathepsin E has an important role in the class II MHC Ag processing pathway within dendritic cells

669718

-

-

?

additional information

?

-

Mus musculus

-

cathepsin E is located in mast-cell secretory granules in complex with heparin proteoglycans, and has a role in processing of procarboxypeptidase A into active protease

669583

-

-

?