3.4.23.34: cathepsin E

This is an abbreviated version!
For detailed information about cathepsin E, go to the full flat file.

Reaction

similar to cathepsin D, but slightly broader specificity =

Synonyms

CatE, Cathepsin D-like acid proteinase, cathepsin D-like aspartic proteinase, cathepsin D-like protease, Cathepsin D-type proteinase, cathepsin E, Cathepsin E-like acid proteinase, CE, CTSE, EMAP, erythrocyte membrane acid proteinase, Erythrocyte membrane aspartic proteinase, gastric mucosa non-pepsin acid proteinase, More, Non-pepsin proteinase, slow moving proteinase, Slow-moving proteinase, SMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.34 cathepsin E

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Results	in table
12	Activating Compound
695	AA Sequence
7	Application
1	CAS Registry Number
34	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
372	Disease/ Diagnostics
3	Expression
3	General Information
2	General Stability
15	IC50 Value
118	Inhibitors
1	kcat/KM [mM/s]
18	Ki Value [mM]
51	KM Value [mM]
65	Localization
1	Metals/Ions
55	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
70	Organism
2	PDB ID
12	pH Optimum
9	pH Range
18	pH Stability
1	pI Value
18	Posttranslational Modification
13	Protein Variants
25	Purification (Commentary)
1	Reaction
2	Reaction Type
70	Reference
193	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
157	Substrates and Products (Substrate)
35	Subunits
35	Synonyms
19	Temperature Optimum [°C]
10	Temperature Stability [°C]
60	Turnover Number [1/s]

General Information

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General Information on EC 3.4.23.34 - cathepsin E

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

-

enzyme-deficient mice are highly resistant to myelin oligodendrocyte glycoprotein 35-55-induced mechanical allodynia

754975

physiological function

2 entries

physiological function

Homo sapiens

-

cathepsin E specifically induces growth arrest and apoptosis in a variety of human prostate cancer cell lines in vitro by catalyzing the proteolytic release of soluble tumor necrosis factor-related apoptosis-inducing ligand from tumor cell surface and prevents tumor growth and metastasis in vivo through multiple mechanisms, including induction of apoptosis angiogenesis inhibition and enhanced immune responses

707628

physiological function

Mus musculus

-

cathepsin E in neutrophils contributes to the generation of mechanical allodynia in experimental autoimmune encephalomyelitis. The enzyme is required for the enzymatic activity of elastase in neutrophils after myelin oligodendrocyte glycoprotein 35-55 stimulation

754975