3.4.23.34: cathepsin E

This is an abbreviated version!
For detailed information about cathepsin E, go to the full flat file.

Reaction

similar to cathepsin D, but slightly broader specificity =

Synonyms

CatE, Cathepsin D-like acid proteinase, cathepsin D-like aspartic proteinase, cathepsin D-like protease, Cathepsin D-type proteinase, cathepsin E, Cathepsin E-like acid proteinase, CE, CTSE, EMAP, erythrocyte membrane acid proteinase, Erythrocyte membrane aspartic proteinase, gastric mucosa non-pepsin acid proteinase, More, Non-pepsin proteinase, slow moving proteinase, Slow-moving proteinase, SMP

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.34 cathepsin E

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Results	in table
12	Activating Compound
695	AA Sequence
7	Application
1	CAS Registry Number
34	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
372	Disease/ Diagnostics
3	Expression
3	General Information
2	General Stability
15	IC50 Value
118	Inhibitors
1	kcat/KM [mM/s]
18	Ki Value [mM]
51	KM Value [mM]
65	Localization
1	Metals/Ions
55	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
70	Organism
2	PDB ID
12	pH Optimum
9	pH Range
18	pH Stability
1	pI Value
18	Posttranslational Modification
13	Protein Variants
25	Purification (Commentary)
1	Reaction
2	Reaction Type
70	Reference
193	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
157	Substrates and Products (Substrate)
35	Subunits
35	Synonyms
19	Temperature Optimum [°C]
10	Temperature Stability [°C]
60	Turnover Number [1/s]

Engineering

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Engineering on EC 3.4.23.34 - cathepsin E

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

D98A/D283A

Mus musculus

-

expression in HEK293T cells

679028

D283A

Rattus norvegicus

-

site-directed mutagenesis

651797

D283E

Rattus norvegicus

-

site-directed mutagenesis

651797

D98A

Rattus norvegicus

-

site-directed mutagenesis

651797

D98A/D283A

2 entries

D98E

Rattus norvegicus

-

site-directed mutagenesis

651797

D98E/D283E

Rattus norvegicus

-

double mutant, site-directed mutagenesis

651797

N324D

Rattus norvegicus

-

N-glycosylation-deficient mutant is neither processed into a mature form nor transported to the endosomal compartement, but is stable retained in the endoplasmic reticulum without degradation

668563

N92Q

Rattus norvegicus

-

N-glycosylation-deficient mutant is neither processed into a mature form nor transported to the endosomal compartement, but is stable retained in the endoplasmic reticulum without degradation

668563

N92Q/N374D

Rattus norvegicus

-

N-glycosylation-deficient mutant is neither processed into a mature form nor transported to the endosomal compartement, but is stable retained in the endoplasmic reticulum without degradation

668563

T284S

Rattus norvegicus

-

site-directed mutagenesis

651797

additional information

Rattus norvegicus

-

construction of two fusion proteins using chimeric DNAs encoding the cathepsin E propeptide fused to the mature cathepsin D tagged with HA at the COOH terminus and encoding the cathepsin D propeptide fused to the mature cathepsin E

669151

D98A/D283A

Rattus norvegicus

-

double mutant, site-directed mutagenesis

651797

D98A/D283A

Rattus norvegicus

-

mutant enzyme has no catalytic activity on either protein or synthetic substrates. In contrast with wild-type cathepsin E, the mutant enzyme is neither processed nor matured even after a 24-h chase period, but stably remains as a 46000 Da precursor

668563