3.4.23.34: cathepsin E

This is an abbreviated version!
For detailed information about cathepsin E, go to the full flat file.

Word Map on EC 3.4.23.34

3.4.23.34

cathepsins

proteinases

pepstatin

pepsinogen

procathepsin

molecular biology

gastricsin

medicine

foveolar

non-lysosomal

3.4.23.5

Reaction

similar to cathepsin D, but slightly broader specificity =

Synonyms

CatE, Cathepsin D-like acid proteinase, cathepsin D-like aspartic proteinase, cathepsin D-like protease, Cathepsin D-type proteinase, cathepsin E, Cathepsin E-like acid proteinase, CE, CTSE, EMAP, erythrocyte membrane acid proteinase, Erythrocyte membrane aspartic proteinase, gastric mucosa non-pepsin acid proteinase, More, Non-pepsin proteinase, slow moving proteinase, Slow-moving proteinase, SMP

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.34 cathepsin E

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
12	Activating Compound
695	AA Sequence
7	Application
1	CAS Registry Number
34	Cloned(Commentary)
16	Cofactor
1	Crystallization (Commentary)
372	Disease/ Diagnostics
3	Expression
3	General Information
2	General Stability
15	IC50 Value
118	Inhibitors
1	kcat/KM [mM/s]
18	Ki Value [mM]
51	KM Value [mM]
65	Localization
1	Metals/Ions
55	Molecular Weight [Da]
6	Natural Substrates/ Products (Substrates)
70	Organism
2	PDB ID
12	pH Optimum
9	pH Range
18	pH Stability
1	pI Value
18	Posttranslational Modification
13	Protein Variants
25	Purification (Commentary)
1	Reaction
2	Reaction Type
70	Reference
193	Source Tissue
7	Specific Activity [micromol/min/mg]
3	Storage Stability
157	Substrates and Products (Substrate)
35	Subunits
35	Synonyms
19	Temperature Optimum [°C]
10	Temperature Stability [°C]
60	Turnover Number [1/s]

Activating Compound

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Activating Compound on EC 3.4.23.34 - cathepsin E

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Activating Compound Search

6-(4-chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

Homo sapiens

CITCO

677830

GTP

Homo sapiens

activation, maintains enzyme in its active conformation at pH 5 and above

30784

IGCEERSFPNIIIIIG

Rattus norvegicus

up to 260% activation of cythepsin E, KD value about 300 nM. Treatment of HeLa cells with cathepsin E and peptide results in decrease in cell viability, with a 1.5- and 3-fold increase in the level of apoptosis in comparison to cells treated with cathepsin E alone

717685

PGIKPPPCIIIIG

Rattus norvegicus

up to 180% activation of cythepsin E

Phenobarbital

SPIISHIVGCDPPSCG

up to 160% activation of cythepsin E

717685

additional information

6 entries