3.4.23.30: Pycnoporopepsin

This is an abbreviated version!
For detailed information about Pycnoporopepsin, go to the full flat file.

Reaction

Similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala14-/-Leu, Tyr16-/-Leu, and Phe24-/-Phe =

Synonyms

carboxyl proteinase I, EC 3.4.23.6, EC 3.4.4.17, EC 3.4.99.25, Proteinase Ia, Proteinase, Pycnoporus coccineus aspartic, Proteinase, Trametes acid, Trametes acid proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.30 Pycnoporopepsin

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Results	in table
1	CAS Registry Number
1	Crystallization (Commentary)
1	Localization
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
5	Organism
2	pH Optimum
2	pI Value
2	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
3	Source Tissue
1	Specific Activity [micromol/min/mg]
14	Substrates and Products (Substrate)
1	Subunits
8	Synonyms

Substrates Products

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Substrates Products on EC 3.4.23.30 - Pycnoporopepsin

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

angiotensin + H2O

?

2 entries

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser + H2O

Asp-Arg-Val-Tyr + Ile-His-Pro-Phe-His-Leu-Leu + Val-Tyr-Ser

Trametes sanguinea

-

cleavage of Tyr-Ile and Leu-Val

30559

-

-

?

casein + H2O

?

Trametes coccinea

-

-

668792

-

-

?

FVNQHLCGSHLVEALYLVCGERGFFYTPKA + H2O

FVNQHLCGSHLVEA + Leu-Val + LVCGERGF + FYTPKA

Trametes coccinea

-

i.e. oxidized insulin B chain, cleavage site specificity of isozymes Ia and Ib at pH 2.7, overview

668792

-

-

?

Hemoglobin + H2O

?

Trametes coccinea

-

-

668792

-

-

?

Native insulin + H2O

Hydrolyzed insulin

Trametes sanguinea

-

Ala14-Leu15, Tyr16-Leu17 and Phe24-Phe25 bonds are hydrolyzed

30751

-

30751

?

Oxidized B-chain of insulin + H2O

Hydrolyzed insulin B-chain

Trametes sanguinea

-

Ala14-Leu15, Tyr16-Leu17 and Phe24-Phe25 bonds are hydrolyzed primarily

30750

-

30750

?

Oxidized insulin peptide B1-B16 + H2O

?

Trametes sanguinea

-

hydrolysis at His10-Leu11 and Ala14-Leu15

30752

-

-

?

pro-angiotensin + H2O

?

Trametes coccinea

-

cleavage at Tyr4-Ile5 and Phe8-Phe9, at pH 2.7

668792

-

-

?

Proangiotensin + H2O

?

Trametes sanguinea

-

formerly designated angiotensin I, hydrolysis of Tyr4-Ile5

30752

-

-

?

additional information

?

-

3 entries

angiotensin + H2O

?

Trametes coccinea

-

cleavage at Tyr4-Ile5, at pH 2.7

668792

-

-

?

angiotensin + H2O

?

Trametes sanguinea

-

formerly designated angiotensin II, hydrolysis of Tyr4-Ile5

30752

-

-

?

additional information

?

-

Trametes coccinea

-

the extracellular enzyme is involved in fungal nutrition from wood

668792

-

-

?

additional information

?

-

Trametes coccinea

-

cleavage site specificity of the isoymes, no activity with isulin A chain, overview

668792

-

-

?

additional information

?

-

Trametes sanguinea

-

not: oxidized insulin peptide B15-B24, peptide bonds which have a hydrophobic amino acid in the P1' position are preferentially cleaved

30752

-

-

?